Chronological Changes in Skeletal Muscle Mass Two Years after Minimally Invasive Esophagectomy: A Prospective Cohort Study

Yoshida, Shinya; Nishigori, Tatsuto; Tsunoda, Shigeru; Tanaka, Eiji; Okabe, Hiroshi; Kobayashi, Ami; Nobori, Yukiko; Obama, Kazutaka; Hisamori, Shigeo; Shide, Kenichiro; Inagaki, Nobuya; Sakai, Yoshiharu

doi:10.1007/s00464-021-08440-y

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…In this study, we found a statistically significant decrease in VHDM after surgery. This finding was similar to that of a prospective cohort study by Yoshida and colleagues ( 28 ), who found that the skeletal muscle mass index of 71 patients decreased statistically significantly 2 years after esophagectomy. This observation may be due to lack of physical exercise or surgical stress, which is known to accelerate lipolysis and proteolysis, leading to the consumption of muscle proteins ( 29 ).…”

Section: Discussionsupporting

confidence: 91%

Intraindividual Reliability of Opportunistic Computed Tomography–Assessed Adiposity and Skeletal Muscle Among Breast Cancer Patients

Aduse‐Poku

Gopireddy

Hernandez

et al. 2022

JNCI Cancer Spectrum

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Background Adiposity and skeletal muscle levels assessed on computed tomography (CT) scans are prognostic indicators for patients with breast cancer. However, the intraindividual reliability of temporal changes in body composition assessed on opportunistic CT scans is unclear. Methods This retrospective study included 50 patients newly diagnosed with breast cancer who had archived CT scans pre- and post-surgery for breast cancer. The third lumbar CT image was segmented for areas of three types of adipose tissues and five different densities of skeletal muscles. Mean and percent changes in areas pre- vs. post-surgery were compared using Wilcoxon signed rank tests. Intraclass correlation coefficients (ICCs) with 95% CIs were assessed. A two-sided p < 0.05 was considered statistically significant. Results Mean (SD) age at diagnosis was 58.3 (12.5) years, and the interval between CT scans was 590.6 (536.8) days. Areas for body composition components were unchanged except for intermuscular adipose tissue (mean change 1.45 cm2, 6.74% increase, p = 0.008) and very high-density muscle (mean change –0.37 cm2, 11.08% decrease, p = 0.011) during the interval. There was strong intraindividual reliability in adipose tissue and skeletal muscle areas on pre- vs. post-surgery scans overall (ICC = 0.763–0.998) and for scans collected ≤3 years apart (ICC = 0.802–0.999; 42 patients). Conclusion Although some body composition components may change after breast cancer surgery, CT scan assessments of body composition were reliable for a 3-year interval including the surgery. These findings inform measurement characteristics of body composition on opportunistic CT scans of patients undergoing surgery for breast cancer.

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Section: Discussionsupporting

confidence: 91%

Intraindividual Reliability of Opportunistic Computed Tomography–Assessed Adiposity and Skeletal Muscle Among Breast Cancer Patients

Aduse‐Poku

Gopireddy

Hernandez

et al. 2022

JNCI Cancer Spectrum

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“…In addition, in older patients, the SMI from after NAC to 12 months postoperatively was significantly lower than the SMI before NAC. Previous studies showed that the SMM at 12–36 months after surgery was lower than the preoperative SMM in patients with oesophageal cancer 24–26. However, the mean age of the patients in these previous studies was 63–67 years,24–26 indicating that there was less information on older patients.…”

Section: Discussionmentioning

confidence: 90%

“…Previous studies showed that the SMM at 12–36 months after surgery was lower than the preoperative SMM in patients with oesophageal cancer 24–26. However, the mean age of the patients in these previous studies was 63–67 years,24–26 indicating that there was less information on older patients. Additionally, there was a lack of information regarding the long-term recovery course of SMM in older patients after oesophagectomy following NAC.…”

Section: Discussionmentioning

confidence: 90%

Skeletal muscle mass recovery after oesophagectomy and neoadjuvant chemotherapy in oesophageal cancer: retrospective cohort study

Harada

Tsuji

Yanagisawa

et al. 2023

BMJ Support Palliat Care

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ObjectiveSkeletal muscle mass (SMM) is an important biomarker for prognosis and health in older patients with cancer. Limited information is available on the recovery course of SMM after oesophagectomy following neoadjuvant chemotherapy (NAC) in older patients. This study was performed to investigate the recovery course of SMM after oesophagectomy following NAC and the preoperative predictors of delayed recovery in older patients with locally advanced oesophageal cancer (LAEC).MethodsThis single-centre retrospective cohort study involved older (≥65 years) and non-older (<65 years) patients with LAEC who underwent oesophagectomy following NAC. The SMM index (SMI) was calculated using CT images. One-way analysis of variance and multivariate logistic regression analysis were performed.ResultsIn total, 110 older patients and 57 non-older patients were analysed. Loss of the SMI after NAC to 12 months postoperatively was significantly greater in older patients than in non-older patients (p<0.01). The significant preoperative predictor of delayed recovery of the SMI 12 months after surgery was loss of the SMI during NAC in older patients (per 1%: adjusted OR 1.249; 95% CI 1.131 to 1.403; p<0.001), but not in non-older patients (per 1%: OR 1.074; 95% CI 0.988 to 1.179; p=0.108).ConclusionsThere is an especially large unmet need for preventing the long-term sequelae of SMM loss in older patients with LAEC after oesophagectomy following NAC. In older patients, loss of SMM during NAC is an especially useful biomarker for prescribing postoperative rehabilitation to prevent postoperative loss of SMM.

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“…For instance, Tan et al [ 22 ] employed computed tomography (CT) data to retrospectively diagnose sarcopenia in esophageal cancer patients, revealing a sarcopenia prevalence of 75.9%. Conversely, Yoshida et al [ 23 ] conducted a prospective study involving 71 patients with esophageal cancer, utilizing the bioelectrical impedance analysis (BIA) method to diagnose sarcopenia, and reported a sarcopenia prevalence of 40.8% in this cohort. Despite discrepancies in diagnostic criteria and methods, sarcopenia was frequently diagnosed during preoperative examinations in patients with esophageal cancer.…”

Section: Introductionmentioning

confidence: 99%

Correlation between sarcopenia and esophageal cancer: a narrative review

Li,

Xie,

Xiao

et al. 2024

World J Surg Onc

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Background In recent years, the research on the relationship between sarcopenia before and after the treatment of esophageal cancer, as well as its impact on prognosis of esophageal cancer, has increased rapidly, which has aroused people’s attention to the disease of patients with esophageal cancer complicated with sarcopenia. This review examines the prevalence of sarcopenia in patients with esophageal cancer, as well as the relationship between sarcopenia (before and after surgery or chemotherapy) and prognosis in patients with esophageal cancer. Moreover, we summarized the potential pathogenesis of sarcopenia and pharmacologic and non-pharmacologic therapies. Methods A narrative review was performed in PubMed and Web of Science using the keywords (“esophageal cancer” or “esophageal neoplasm” or “neoplasm, esophageal” or “esophagus neoplasm” or “esophagus neoplasms” or “neoplasm, esophagus” or “neoplasms, esophagus” or “neoplasms, esophageal” or “cancer of esophagus” or “cancer of the esophagus” or “esophagus cancer” or “cancer, esophagus” or “cancers, esophagus” or “esophagus cancers” or “esophageal cancer” or “cancer, esophageal” or “cancers, esophageal” or “esophageal cancers”) and (“sarcopenia” or “muscular atrophy” or “aging” or “senescence” or “biological aging” or “aging, biological” or “atrophies, muscular” or “atrophy, muscular” or “muscular atrophies” or “atrophy, muscle” or “atrophies, muscle” or “muscle atrophies”). Studies reporting relationship between sarcopenia and esophageal cancer were analyzed. Results The results of the review suggest that the average prevalence of sarcopenia in esophageal cancer was 46.3% ± 19.6% ranging from 14.4 to 81% and sarcopenia can be an important predictor of poor prognosis in patients with esophageal cancer. Patients with esophageal cancer can suffer from sarcopenia due to their nutritional deficiencies, reduced physical activity, chemotherapy, and the effects of certain inflammatory factors and pathways. When classic diagnostic values for sarcopenia such as skeletal muscle index (SMI) are not available clinically, it is also feasible to predict esophageal cancer prognosis using simpler metrics, such as calf circumference (CC), five-count sit-up test (5-CST), and six-minute walk distance (6MWD). Conclusions Identifying the potential mechanism of sarcopenia in patients with esophageal cancer and implementing appropriate interventions may hold the key to improving the prognosis of these patients.

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Chronological Changes in Skeletal Muscle Mass Two Years after Minimally Invasive Esophagectomy: A Prospective Cohort Study

Cited by 5 publications

References 42 publications

Intraindividual Reliability of Opportunistic Computed Tomography–Assessed Adiposity and Skeletal Muscle Among Breast Cancer Patients

Intraindividual Reliability of Opportunistic Computed Tomography–Assessed Adiposity and Skeletal Muscle Among Breast Cancer Patients

Skeletal muscle mass recovery after oesophagectomy and neoadjuvant chemotherapy in oesophageal cancer: retrospective cohort study

Correlation between sarcopenia and esophageal cancer: a narrative review

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