Chronological age or biological age: What drives the choice of adjuvant treatment in elderly breast cancer patients?

Maltoni, Roberta; Ravaioli, Sara; Bronte, Giuseppe; Mazza, Massimiliano; Cerchione, Claudio; Nanni, Oriana; Balzi, William; Cortesi, Michela; Zanoni, Michele; Bravaccini, Sara

doi:10.1016/j.tranon.2021.101300

Cited by 22 publications

(13 citation statements)

References 18 publications

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“…However, this is consistent with our data from OPSCC, suggesting that overall performance status is more important than the physical age of the patient. Also, this is consistent with the suggestion that not only chronological but also biological age and functional status (and probably other factors) should be considered when selecting the best cancer treatment [ 45 , 46 , 47 ].…”

Section: Discussionsupporting

confidence: 88%

Predictors for Survival of Patients with Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region

Wagner

Langer

Wuerdemann

et al. 2023

Cancers

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Background: Human papillomavirus (HPV) status is the most important predictor of survival in oropharyngeal squamous cell carcinoma (OPSCC). In patients with cervical lymph node metastases of squamous cell carcinoma of unknown origin (CUPHNSCC), much less is known. Methods: We assessed a consecutive cohort of CUPHNSCC diagnosed from 2000–2018 for HPV DNA, mRNA, p16INK4a (p16) expression, and risk factors to identify prognostic classification markers. Results: In 32/103 (31%) CUPHNSCC, p16 was overexpressed, and high-risk HPV DNA was detected in 18/32 (56.3%). This was mostly consistent with mRNA detection. In recursive partitioning analysis, CUPHNSCC patients were classified into three risk groups according to performance status (ECOG) and p16. Principal component analysis suggests a negative correlation of p16, HPV DNA, and gender in relation to ECOG, as well as a correlation between N stage, extranodal extension, and tobacco/alcohol consumption. Conclusions: Despite obvious differences, CUPHNSCC shares similarities in risk profile with OPSCC. However, the detection of p16 alone appears to be more suitable for the classification of CUPHNSCC than for OPSCC and, in combination with ECOG, allows stratification into three risk groups. In the future, additional factors besides p16 and ECOG may become important in larger studies or cases with special risk profiles.

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Section: Discussionsupporting

confidence: 88%

Predictors for Survival of Patients with Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region

Wagner

Langer

Wuerdemann

et al. 2023

Cancers

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“…These investigations might point to a possible connection between IR and age; however, all of them were done with a focus on chronological age (CA). CA refers to the length of time that a person experiences from birth to the present moment while BA reflects the physiological and functional performance that corresponds to a specific CA, it takes into account the factors such as time elapse, genetics, nutrition, and so on [ 17 ]. Some scholars have recently discovered that BA can better represent a person's physiological function and aging level more than CA, and BA is more consistent with an individual's "true life expectancy" [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

Yang,

Gong,

Liu

et al. 2023

Eur J Med Res

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Background Insulin resistance (IR) had been reported to be associated with age; however, few studies have explored the association between IR and biological age (BA). The HOMA-IR value is a useful indicator of the extent of IR. This cross-sectional study is to explore the relationship between HOMA-IR and BA/advanced aging in the US population. Methods This study is a cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) data. The survey comprised 12,266 people from the NHANES, and their full HOMA-IR data as well as BA data were extracted. Four multiple linear regressions were performed to analyze the association between HOMA-IR and BA, and four multiple logistic regression models were performed to analyze the association between HOMA-IR and advanced aging. In addition, trend tests and stratified analysis were performed and smoothed fitted curves were plotted to test the robustness of the results. Results HOMA-IR was positively correlated with BA [β: 0.51 (0.39, 0.63)], and it was the same to advanced aging [OR: 1.05 (1.02, 1.07)], and both showed a monotonically increasing trend. The trend tests showed that the results were stable (all P for trend < 0.0001). The smoothed fitted curves showed that there were non-linear relationships between HOMA-IR and BA/advanced aging. And the stratified analysis indicated that the relationship between HOMA-IR and BA/advanced aging remained robust in all subgroups. Conclusion The study suggested that HOMA-IR is positively correlated with BA and advanced aging in the US adult population, with a monotonic upward trend. This is a new finding to reveal the relationship between HOMA-IR and age from new standpoint of BA rather than chronological age (CA). And it may contribute to a better understanding of human health aging and may aid future research in this field.

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“…To counter age-biases in research, the National Institute of Health now expects inclusion across the lifespan and explicitly require justification for age exclusions in its funded research portfolio ( 29 ). But nuance is also called for here, as chronological age categories are often distinct from biological/ functional statuses and have different treatment implications ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Health equity innovation in precision medicine: Current challenges and future directions

Ory

Adepoju²,

Ramos³

et al. 2023

Front. Public Health

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Chronological age or biological age: What drives the choice of adjuvant treatment in elderly breast cancer patients?

Cited by 22 publications

References 18 publications

Predictors for Survival of Patients with Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region

Predictors for Survival of Patients with Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region

HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

Health equity innovation in precision medicine: Current challenges and future directions

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