Chronobiology's progress. Part II, chronomics for an immediately applicable biomedicine

Halberg, Franz; Cornélissen, Germaine; Katinas, George; Tvildiani, Levan; Gigolashvili, M. Sh.; Janashia, Ketevan; Toba, Tim; Revilla, Miguel; Regal, Philip J.; Sothern, Robert B.; Wendt, H.; Wang, Zhengrong; Zeman, Michal; Józsa, R.; Singh, Ram B.; Mitsutake, G.; Чибисов, С. М.; Lee, Jong; Holley, Daniel C.; Holte, J.; Sonkowsky, Robert P.; Schwartzkopff, Othild; Delmore, Patrick; Otsuka, Kuniaki; Bakken, Earl E.; Czaplicki, Jerzy

doi:10.32725/jab.2006.007

Cited by 19 publications

(8 citation statements)

References 23 publications

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“…It will be used to improve estimates over a range and to correlate a variable with the multifrequency and the modulations of biological rhythms. Thus, the diagnosis/analysis may be correlated with biological systems with different paces [24]. …”

Section: Chronomicsmentioning

confidence: 99%

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Application of Bioinformatics in Chronobiology Research

Lopes

Resende

Honório-França

et al. 2013

The Scientific World Journal

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Bioinformatics and other well-established sciences, such as molecular biology, genetics, and biochemistry, provide a scientific approach for the analysis of data generated through “omics” projects that may be used in studies of chronobiology. The results of studies that apply these techniques demonstrate how they significantly aided the understanding of chronobiology. However, bioinformatics tools alone cannot eliminate the need for an understanding of the field of research or the data to be considered, nor can such tools replace analysts and researchers. It is often necessary to conduct an evaluation of the results of a data mining effort to determine the degree of reliability. To this end, familiarity with the field of investigation is necessary. It is evident that the knowledge that has been accumulated through chronobiology and the use of tools derived from bioinformatics has contributed to the recognition and understanding of the patterns and biological rhythms found in living organisms. The current work aims to develop new and important applications in the near future through chronobiology research.

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Section: Chronomicsmentioning

confidence: 99%

“…Physiological chronomes and their unique features are calculated within a specific range that is much shorter than the range of the observations of the system as a whole. However, this integrated analysis system is an increment of diagnosis [20, 22–24]. …”

Section: Chronomicsmentioning

confidence: 99%

Application of Bioinformatics in Chronobiology Research

Lopes

Resende

Honório-França

et al. 2013

The Scientific World Journal

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“…edu/~halberg/). The authors from several continents in the bibliography (Halberg et al 2006) deserve the credit for contributions summarized herein, but stand on the shoulders of many more in the bibliography on the website, among others (Huntington 1915(Huntington , 1938.…”

Section: Preamblementioning

confidence: 99%

“…The term "aeolian" would include the phenomena described by Bartels as quasipersistence in quasi-periodic variables, reported by him in plots such as Fig. 2a (Bartels 1936(Bartels , 1959, but would require the procedural desiderata of chronomics, estimates of the uncertainties involved, Figs 3b, 3d, 3e -see Halberg et al (2006). Fig.…”

Section: Aeolian (Noun and Adjective)mentioning

confidence: 99%

“…The difference between looking only for swelling, redness, heat and pain (tumor, rubor, calor and dolor) on the one hand versus making histological and other laboratory examinations of a questionably cancerous tissue and drawing blood for cancer markers, on the other hand, can be compared with the difference between the very many " cycles" reported with neglect of the uncertainties invariably involved in each case on the one hand vs. an attempt to meet the above mentioned desiderata on the other hand (see Halberg et al 2006). To add the now available uncertainty (interval) estimates such as CIs to each point estimate of a parameter, as suggested in Insert I in Halberg et al (2006), is but a first provisional step.…”

Section: Further Analogies: Beyond Original Cosinorsmentioning

confidence: 99%

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Chronobiology's progress. Part I, season's appreciations 2004-2005: time-, frequency-, phase-, variable-, individual-, age- and site-specific chronomics

Halberg

Cornélissen²,

Katinas³

et al. 2006

JAB

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New components of transdisciplinary spectra or known components in new variables in us, matching those around us, are being mapped. Their hardly trivial interactions associated with the good and bad around us -from religiosity to crime and war -are being rendered measurable, for the eventual development of countermeasures to the diseases of societies and nations. Internal cycles not only underlie life itself and underlie our evolving genetics at all levels of organization; they also constitute the essential control and reference information in all transdisciplinary science. In preparing for travel to Mars and other missions in space that may take more than a year, let us do what is immediately practicable. Transyears may have very small amplitudes yet are associated with sudden cardiac death in some terrestrial locations; if they should play a role in these electrical incidents of the heart, among others like myocardial infarction and stroke, they will jeopardize lengthy missions in extraterrestrial space, away from hospitals.The likelihood of stroke or cardiac death can be immediately reduced by chronobiologically assessing blood pressure and heart rate variability and by optimizing the efficacy of timed treatment rather than relying on an unacceptable and often inaccurate spotcheck and treating by convenience rather than pertinence. Needed are: detection of nocturnal abnormality when medication may no longer be effective (or is too effective) neither seen during office visits by day; detection of circadian hyperamplitude-tension (CHAT) associated with a risk of stroke and kidney disease greater than other risks Halberg et al.: Chronobiology's progress I 2 (including "hypertension" when all risks are assessed concomitantly); detection of CHAT as high risk among normotensives who may not need anti-hypertensive medication; individualized inferential statistical testing to determine whether a drug or non-drug intervention such as autogenic training (relaxation) is effective and for how long (detecting any initial and later success or failure), some of which conditions otherwise are not found without chronobiology; individualization of treatment timing, since the same dose of the same medication can further lower the subject's blood pressure average and circadian amplitude when the timing of daily administration is optimized, as ascertained by sequential testing and parameter tests.Thus, we save lives by monitoring and assessing, and if need be treating, vascular disease risk through chronobiologically interpreted 24-hour or preferably longer (24-hour/7-day) blood pressure and heart rate variability. Abnormalities in the variability of blood pressure and heart rate, impossible to find during a conventional office visit (the latter aiming at the fiction of a "true" blood pressure), can raise cardiovascular disease risk in the next six years from 4% to 100%.· Dedicated to Alejandro Zaffaroni, who came as a pleasant surprise with flowers and more. May a marker-guided preventive chronotherapy of elevations of the risks ...

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