Chronobiology of urinary citrate excretion amongst stone-formers and healthy males from North Western India

Wangoo, D.; Thind, S. K.; Gupta, G. S.; Nath, R.

doi:10.1007/bf00303752

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…It is worth noting a circadian variation in the urinary excretion of different solutes has been documented in healthy individuals: notably, the nocturnal excretion rates of potassium, sodium, chloride, and urate are only 50% of the rates observed during the light period [ 49 ], whereas phosphate reabsorption at night is more than that during the day [ 50 ]. Also, urinary pH and calcium showed a circadian variation in healthy subjects [ 51 ] In patients known to form stones; it has been demonstrated there is impaired circadian rhythmicity of urinary volume and some solutes excretion [ 52 , 53 , 54 , 55 , 56 ]. This was the first genetic polymorphism investigation to link the MTNR1A–biological melatonin system to calcium nephrolithiasis.…”

Section: Discussionmentioning

confidence: 99%

Melatonin receptor 1A gene polymorphism rs13140012 and serum melatonin in atherosclerotic versus non-atherosclerotic Egyptian ESRD patients: pilot study

Aghoury

Tayae

Kholy

et al. 2020

Heliyon

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Aim To study the relationship between melatonin levels and Melatonin membrane receptor 1A ( MTNR1A ) SNP (rs13140012) in end-stage renal disease patients (ESRD) in Alexandria, Egypt on maintenance hemodialysis with or without atherosclerosis. Materials and methods 40 end-stage renal disease patients on regular hemodialysis were divided into 2 subgroups, one with (n = 20) and one without atherosclerosis (n = 20) and normal subjects (n = 40). Serum melatonin, carotid intimal medial thickness (CIMT) were measured. Melatonin membrane receptor 1A ( MTNR1A ) SNP (rs13140012) genotyping was done using 5'nuclease Allelic discrimination. Results Serum melatonin was significantly lower in ESRD patients [1.6 to 11.30 (pg/mL) with a median of 2.5] than the control group [20.50 to 56.40 (pg/mL) with a median of 35.20]. Serum melatonin was significantly lower in atherosclerotic patients subgroup [1.6–2.50 (pg/mL) with a median value of 2.30] than non-atherosclerotic patients subgroup [2.0–11.30 (pg/mL) with a median of 4.9]. No significant association was found between serum melatonin and ( MTNR1A ) SNP (rs13140012) (p = 0.633). Conclusion These results lead us to suggest that melatonin production is impaired in ESRD patients (included in this pilot study), and this impairment is more evident in atherosclerotic ESRD patients.

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Section: Discussionmentioning

confidence: 99%

Melatonin receptor 1A gene polymorphism rs13140012 and serum melatonin in atherosclerotic versus non-atherosclerotic Egyptian ESRD patients: pilot study

Aghoury

Tayae

Kholy

et al. 2020

Heliyon

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“…A signi fi cantly higher level of serum urate was found in stone patients as compared with non-stone cases, even though the values were within the normal range [ 49 ] . Children consuming wheat as a staple diet are at a greater risk of forming a stone because of the increased urine saturation and precipitation of urate [ 50 ] .…”

Section: Hyperuricosuriamentioning

confidence: 99%

Epidemiology of Stone Disease in Northern India

Ganesamoni¹,

Singh²

2012

Urolithiasis

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Urinary stone disease is highly prevalent in North India, a part of the stone belt in Asia. Two distinct "stone belts" have been identi fi ed in the northwestern region (NW); stone disease is less common in the southern and eastern regions. Calcium oxalate (CaOx) comprises a greater proportion of stones than seen in Western studies. While struvite stones were common in older series from NW, CaOx remains the predominant stone now, even in staghorns. First-degree relatives of stone formers are at higher risk of developing urolithiasis and have signi fi cantly higher urinary calcium excretion as compared to the spouses of the stone formers. Urinary tract infection was found to be one of the principal risk factors of urinary stones in North India. Metabolic acidosis is present in up to 45.2 % of stone formers as compared with 10.8 % in non-stone formers. Only dietary calcium correlated signi fi cantly with serum and urine calcium in stone formers. Stone patients from North India were shown to have a signi fi cantly higher intake of dairy products such as curd and cheese as compared to nonstone cases. Lower concentrations of urinary magnesium, copper, and manganese were noted in stone formers. Zinc excretion was signi fi cantly higher in stone formers. A signi fi cantly higher urinary urate excretion has been shown among stone formers from Delhi and Rajasthan.

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Circadian Rhythmometric Studies on the Low Molecular Weight Urinary Inhibitors of Calcium Oxalate Urolithiasis

et al. 1994

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Chronobiology of urinary citrate excretion amongst stone-formers and healthy males from North Western India

Cited by 5 publications

References 6 publications

Melatonin receptor 1A gene polymorphism rs13140012 and serum melatonin in atherosclerotic versus non-atherosclerotic Egyptian ESRD patients: pilot study

Melatonin receptor 1A gene polymorphism rs13140012 and serum melatonin in atherosclerotic versus non-atherosclerotic Egyptian ESRD patients: pilot study

Epidemiology of Stone Disease in Northern India

Circadian Rhythmometric Studies on the Low Molecular Weight Urinary Inhibitors of Calcium Oxalate Urolithiasis

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