Chronobiology of Coronary Risk Markers in Greenland Eskimos: A Comparative Study with Caucasians Residing in the Same Arctic Area

Johansen, L. G.; Gram, Jørgen Brodersen; Kluft, C.; Jespersen, Jørgen

doi:10.3109/07420529109059171

Cited by 12 publications

(13 citation statements)

References 18 publications

(19 reference statements)

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“…We observed diurnal variation in both F1.2 and D-dimer, and have allowed for this in the analyses. Diurnal variation has been described for F1.2 (52) though not for D-dimer in smaller studies (53,54). F1.2 and D-dimer were higher in females than males as previously reported (9,11,20,35), although in our study the difference in the case of D-dimer was significant only in those over 55 years.…”

Section: Discussioncontrasting

confidence: 49%

Haemostatic and Lipid Determinants of Prothrombin Fragment F1.2 and D-dimer in Plasma

MacCallum¹,

Cooper²,

Martin³

et al. 2000

Thromb Haemost

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SummaryThe determinants of plasma levels of prothrombin fragment F1.2 (F1.2) and D-dimer in different populations are unclear and this may complicate their interpretation as predictors of thrombotic risk, particularly in the case of D-dimer. We therefore measured F1.2 and D-dimer levels together with a number of other haemostatic and lipid variables in a cross-sectional community-based study of 150 healthy adults (73 male, 77 female), age range 23-80 years, identified from the list of a general practice by stratified random sampling within sex and decade of age. Plasma F1.2 was significantly higher in females than males and was independently and positively associated with age, factor VII activity (FVIIc) and C1 inhibitor, and inversely associated with high density lipoprotein (HDL) cholesterol. Plasma D-dimer showed a quadratic association with age (p <0.0001). In those ≤55 years D-dimer was inversely associated with dilute clot lysis time (DCLT) and activated protein C (APC) ratio. In those >55 years it was significantly higher in females than males and associated positively with age, fibrinogen and, in males, activated factor XII (FXIIa). In a multiple-linear model which combined both age groups, F1.2 and D-dimer were independently associated with each other (r = 0.22, p = 0.03). Thus, thrombin generation and fibrin turnover/fibrinolysis are associated in healthy subjects. HDL cholesterol (inversely) and FVIIc are associated with basal thrombin generation (i.e. F1.2). Determinants of D-dimer differ according to age and interpretation of the biological significance of D-dimer levels in epidemiological studies may therefore not be straightforward.

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Section: Discussioncontrasting

confidence: 49%

Haemostatic and Lipid Determinants of Prothrombin Fragment F1.2 and D-dimer in Plasma

MacCallum¹,

Cooper²,

Martin³

et al. 2000

Thromb Haemost

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“…Previous studies of D-dimer on a small number of subjects (nϽ15) did not find a diurnal variation in D-dimer, 24,25 although another small study did report a morning peak. 26 The present study is the first to report a diurnal pattern in CRP, which was not observed in a previous study of only 13 healthy young volunteers.…”

Section: Diurnal Variationsmentioning

confidence: 90%

“…8 This is supported by other smaller studies. 7,16 As well as seasonal effects, variable reports exist of a diurnal pattern in fibrinogen 12,22,23 and D-dimer, 24 -26 whereas t-PA shows a morning peak with levels that tend to decline during the day; 12,24,27,28 vWF has been reported to show no diurnal variation in 1 small study. 28 Diurnal variation may be an important source of heterogeneity or bias, and standardization for sampling time may be important in populationbased studies, as well as in using these variables for additional coronary heart disease risk prediction in individuals.…”

Section: Clinical Perspective P 1003mentioning

confidence: 99%

Diurnal, Seasonal, and Blood-Processing Patterns in Levels of Circulating Fibrinogen, Fibrin D-Dimer, C-Reactive Protein, Tissue Plasminogen Activator, and von Willebrand Factor in a 45-Year-Old Population

et al. 2007

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Background-Circulating levels of fibrinogen, fibrin D-dimer, C-reactive protein (CRP), tissue plasminogen activator antigen (t-PA) and von Willebrand factor are associated with incident coronary heart disease. We describe cross-sectional diurnal, seasonal, and blood-processing patterns for these variables, and assess whether they represent important sources of variability that should be taken into account in epidemiological studies or for additional risk prediction in individuals. Methods and Results-A total of 9377 men and women aged 45 years were visited in their homes and blood-sampled for fibrinogen, D-dimer, CRP, t-PA, and von Willebrand factor. These variables were examined in relation to the time of blood sample collection, day of the year, and delay in processing. All variables exhibited statistically significant diurnal sinusoidality (PՅ0.02). Our models predicted a peak rise for fibrinogen and von Willebrand factor at midday, with overall diurnal variations of 3% and 10%, respectively, after adjustment for standard cardiovascular risk factors. D-dimer exhibited a peak at 14:00 hours, CRP at 15:00 hours, and t-PA at 10:00 hours with diurnal variations of 10%, 34%, and 55%, respectively, after full adjustment. All variables except CRP showed seasonal heterogeneity. Greater delays in processing blood samples were associated with higher levels of t-PA in particular. The proportion of variation attributed to the diurnal, seasonal, and processing effects was 2% for fibrinogen and von Willebrand factor; 9% for D-dimer, 1% for CRP, and 16% for t-PA. Conclusions-Temporal variations are important sources of heterogeneity that may bias the analysis of epidemiological studies and coronary heart disease risk prediction in individuals. Sample-processing delay is particularly important for t-PA.

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“…Participants' blood was drawn between 8:00 a.m. and 3:00 p.m., and at the same hour of the day at the end of the study for logistical reasons, but also because of the circadian rhythm of especially clot lysis time and PAI-1. [12][13][14] Within 3 h, blood samples were centrifuged at 2500 g for 15 min at 18°C and stored afterwards at À80°C in our biobank.…”

Section: Measurementsmentioning

confidence: 99%

Rosuvastatin use increases plasma fibrinolytic potential: a randomised clinical trial

et al. 2020

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We conducted a study to assess the effect of rosuvastatin use on fibrinolysis in patients with previous venous thromboembolism (VTE). This was a post hoc analysis within the STAtins Reduce Thrombophilia (START) study (NCT01613794). Plasma fibrinolytic potential, fibrinogen, plasmin inhibitor, plasminogen activator inhibitor‐1 (PAI‐1) and thrombin‐activatable fibrinolysis inhibitor (TAFI) were measured before and after four weeks of rosuvastatin or no treatment in participants with prior confirmed VTE, after ending anticoagulant therapy. In the non‐rosuvastatin group (n = 121), plasma fibrinolytic potential and individual fibrinolysis parameters did not change at the end of the study versus the baseline, whereas in the rosuvastatin group (n = 126), plasma fibrinolytic potential increased: the mean clot lysis time decreased by 8·75 min (95% CI −13·8 to −3·72), and plasmin inhibitor levels and TAFI activity were lower at the end of the study (−0·05 U/ml; 95% CI −0·07 to −0·02 and −4·77%; 95% CI −6·81 to −2·73, respectively). PAI‐1 levels did not change and fibrinogen levels were 0·17 g/l (95% CI 0·04–0·29) higher. In participants with prior VTE, rosuvastatin use led to an increased fibrinolytic potential compared with non‐statin use. Our findings support the need for further studies on the possible role for statins in the secondary prevention of VTE.

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Chronobiology of Coronary Risk Markers in Greenland Eskimos: A Comparative Study with Caucasians Residing in the Same Arctic Area

Cited by 12 publications

References 18 publications

Haemostatic and Lipid Determinants of Prothrombin Fragment F1.2 and D-dimer in Plasma

Haemostatic and Lipid Determinants of Prothrombin Fragment F1.2 and D-dimer in Plasma

Diurnal, Seasonal, and Blood-Processing Patterns in Levels of Circulating Fibrinogen, Fibrin D-Dimer, C-Reactive Protein, Tissue Plasminogen Activator, and von Willebrand Factor in a 45-Year-Old Population

Rosuvastatin use increases plasma fibrinolytic potential: a randomised clinical trial

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