Chronobiology, endocrinology, and energy‐ and food‐reward homeostasis

Gonnissen, Hanne K J; Hulshof, T.; Westerterp-Plantenga, Margriet S.

doi:10.1111/obr.12019

Cited by 79 publications

(75 citation statements)

References 136 publications

(277 reference statements)

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“…Given the 3-hour shift in bedtimes, a circadian influence on observed differences in leptin is also possible. 33 Differences observed in measured weight provide a potentially compelling link between differences in sleep, reported dietary intake, and fasting leptin. Similar to a laboratory study with adults, 8 compared with the end of the decrease sleep condition, on average children weighed ∼0.22 kg less at the end of the increase sleep condition.…”

Section: Figurementioning

confidence: 99%

Changes in Children’s Sleep Duration on Food Intake, Weight, and Leptin

et al. 2013

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WHAT'S KNOWN ON THIS SUBJECT: Epidemiologic studies have documented that children' s sleep duration is associated with obesity risk. Experimental studies with adults suggest that short sleep may lead to changes in appetite-regulating hormones and food intake, which could lead to weight gain over time. WHAT THIS STUDY ADDS:This controlled experimental study demonstrates that compared to sleeping less, when children increase sleep, they report decreased caloric intake, have lower fasting leptin levels, and weigh less. Such changes, if maintained, could help prevent excess weight gain over time.abstract OBJECTIVE: To examine the effect of experimental changes in children' s sleep duration on self-reported food intake, food reinforcement, appetite-regulating hormones, and measured weight. METHODS:Using a within-subjects, counterbalanced, crossover design, 37 children, 8 to 11 years of age (27% overweight/obese) completed a 3-week study. Children slept their typical amount at home for 1 week and were then randomized to either increase or decrease their time in bed by 1.5 hours per night for 1 week, completing the alternate schedule on the third week. Primary outcomes were dietary intake as assessed by 24-hour dietary recalls, food reinforcement (ie, points earned for a food reward), and fasting leptin and ghrelin. The secondary outcome was child weight.RESULTS: Participants achieved a 2 hour, 21 minute difference in the actigraph defined sleep period time between the increase and decrease sleep conditions (P , .001). Compared with the decrease sleep condition, during the increase condition, children reported consuming an average of 134 kcal/day less (P , .05), and exhibited lower fasting morning leptin values (P , .05). Measured weights were 0.22 kg lower during the increase sleep than the decrease sleep condition (P , .001). There were no differences in food reinforcement or in fasting ghrelin. CONCLUSIONS:Compared with decreased sleep, increased sleep duration in school-age children resulted in lower reported food intake, lower fasting leptin levels, and lower weight. The potential role of sleep duration in pediatric obesity prevention and treatment warrants further study. Pediatrics 2013;132:e1473-e1480 Dr Hart conceptualized and designed the study, obtained funding, oversaw execution of the study, and drafted the initial manuscript; Dr Carskadon helped to design and execute the study and reviewed and revised the manuscript; Dr Considine helped to design the study, analyzed blood samples, and reviewed and revised the manuscript; Dr Fava carried out data analyses and reviewed and revised the manuscript; Ms Lawton coordinated data collection, scored actigraphy data, and reviewed and revised the manuscript; Dr Raynor helped conceptualize and design the study and reviewed and revised the manuscript; Dr Jelalian helped design the study and reviewed and revised the manuscript; Dr Owens helped design the study and reviewed and revised the manuscript; Dr Wing helped conceptualize and design the study and reviewed and revi...

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Section: Figurementioning

confidence: 99%

Changes in Children’s Sleep Duration on Food Intake, Weight, and Leptin

et al. 2013

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“…56,57 The reward system is also intrinsically related to bodyenergy regulation. This system is thought to underlie alterations in some eating behaviours, 58,59 and it has received increasing interest in recent years, being considered a key element in the development and maintenance of anorexia nervosa. 2,60 Actually, several studies have shown that patients with this disorder present deviant responses to the reinforcing characteristics of several types of disorder-relevant and nonrelevant stimuli and that such abnormal responses are probably implicated in the persistence of the pathological behaviour.…”

Section: Changes In the Fornixmentioning

confidence: 99%

Disruption of brain white matter microstructure in women with anorexia nervosa

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Zalesky

Sánchez

et al. 2014

jpn

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“…Another advantage of having a healthier chronotype has to do with the well-established link between biological rhythms and obesity (Gonnissen et al, 2013), something to keep in mind considering that weight gain is a common -and difficult to treat-problem in people with BD and has also been related with a poor prognosis of the illness (Fagiolini et al, 2003). Last, if we consider the increase morbidity described for the bipolar population, it is remarkable the relationship between alterations in circadian rhythms and increased lipid peroxidation (which it's related to increased likelihood of Alzheimer disease and several types of cancer).…”

Section: Discussionmentioning

confidence: 99%