Chronobiology and chronotherapy of ischemic heart disease

Portaluppi, Francesco

doi:10.1016/j.addr.2006.07.029

Cited by 59 publications

(40 citation statements)

References 127 publications

(183 reference statements)

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“…Postprandial TAG levels are higher for meals taken during the night versus the day (10,11), coinciding with a circadian increase in plasma TAG concentrations, as shown here and in other studies (5,36). Given that postprandial lipemia increases risk of atherogenesis (37), and the occurrence of myocardial infarction is greatest near usual wake time (38), interindividual differences in circadian regulation of lipid metabolism could potentially contribute to differential disease risk and health outcomes in persons whose circadian clock is regularly misaligned with feeding and rest-activity cycles. As such, in future studies it will be important to link genetically determined differences in the lipidome with circadian control of energy homeostasis.…”

Section: Discussionmentioning

confidence: 50%

Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans

Chua

Shui

Lee

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

196

183

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The circadian system regulates daily rhythms in lipid metabolism and adipose tissue function. Although disruption of circadian clock function is associated with negative cardiometabolic end points, very little is known about interindividual variation in circadianregulated metabolic pathways. Here, we used targeted lipidomicsbased approaches to profile the time course of 263 lipids in blood plasma in 20 healthy individuals. Over a span of 28 h, blood was collected every 4 h and plasma lipids were analyzed by HPLC/MS. Across subjects, about 13% of lipid metabolites showed circadian variation. Rhythmicity spanned all metabolite classes examined, suggesting widespread circadian control of lipid-mediated energy storage, transport, and signaling. Intersubject agreement for lipids identified as rhythmic was only about 20%, however, and the timing of lipid rhythms ranged up to 12 h apart between individuals. Healthy subjects therefore showed substantial variation in the timing and strength of rhythms across different lipid species. Strong interindividual differences were also observed for rhythms of blood glucose and insulin, but not cortisol. Using consensus clustering with iterative feature selection, subjects clustered into different groups based on strength of rhythmicity for a subset of triglycerides and phosphatidylcholines, suggesting that there are different circadian metabolic phenotypes in the general population. These results have potential implications for lipid metabolism disorders linked to circadian clock disruption.metabolomics | chronobiology T he circadian clock in the suprachiasmatic nucleus (SCN) of the hypothalamus regulates daily rhythms in behavior and physiology, ensuring that metabolic pathways are temporally coordinated with 24-h cycles of rest-activity and feeding (1). The circadian system controls lipid and carbohydrate homeostasis, thus optimizing energy storage and utilization across the day (2). In humans, this is reflected in part by diurnal variation in glucose tolerance (3, 4), as well as circadian rhythms of glucose, insulin, triglycerides, and adipose-derived hormones in blood (5, 6). At the cellular level, circadian rhythms are generated by transcriptional and posttranscriptional feedback loops, with daily rhythms of cell biology driven by core clock genes and their protein products. The SCN neural rhythm is normally entrained by the 24-h solar cycle, whereas the phase of rhythms in peripheral tissues is thought to be determined primarily by daily rest-activity and/or feeding cycles (7).Disruption of circadian rhythms has been implicated in metabolic syndrome and dyslipidemia (2), and chronic circadian misalignment is thought to contribute to increased risk of cardiovascular disease and obesity in shift workers (8, 9). Although the mechanisms have yet to be fully elucidated, consumption of meals at night is associated with higher postprandial triglyceride levels, compared with meals consumed during the daytime (10, 11). In nocturnal mice, the circadian timing of food intake contribut...

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Section: Discussionmentioning

confidence: 50%

Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans

Chua

Shui

Lee

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

196

183

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“…The dipper/ non-dipper classification of nocturnal blood pressure was firstly introduced in 1988 when a retrospective analysis suggested that hypertensive patients without nocturnal fall in BP had a higher risk of stroke than the majority of patients with a dipping pattern [1,2,14]. In non-dipper hypertension the number of cardiac events is three times more compared to the dipper type [5,12,13,[15][16][17]. In asymptomatic hypertensive patients who underwent 24-hour monitoring and brain magnetic resonance imaging, the frequency of asymptomatic cerebrovascular damage (silent infarcts and advanced deep white matter ischemic lesions) was higher in non-dippers as compared to dippers, and extreme dippers had more advanced cerebrovascular lesions [18].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Hypertension: Favourable Effect of the Twice-Daily Compared to the Once-Daily (Evening) Administration of Perindopril and Losartan

Ipoly¹,

Csajági

Major

et al. 2015

Kidney Blood Press Res

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Background/Aims: Little is known about the effect of twice daily administration of same dose of ACE inhibitor and ARB on the diurnal/nocturnal blood pressure (BP) ratio. We aimed to assess the effect of two widely used long-acting drugs: perindopril and losartan in the treatment of hypertension comparing the once-daily (evening) vs. twice-daily (morning and evening) administration with the same daily doses. Methods: Untreated primary hypertensive patients without complaints (a total of 164: 65 men, 99 women, 55.7±13.7 years of age, 41-41 patients per treated groups) were selected with non-dipper phenomenon, estimated by diurnal index (DI) <10%. The effect of evening (8 mg perindopril or 100 mg losartan) vs morning and evening (4-4 mg perindopril or 50-50 mg losartan) administration was determined on a 14-day treatment by ABPM. Results: The mean BP, the percent time elevation index, and the hyperbaric impact decreased in both drug groups. Significant difference was observed in the DI in the case of twice-daily administration vs once-daily evening dosing. Conclusions: The twice-daily administration with the same daily dose of perindopril or losartan seems to be more effective compared to the once daily evening administration in eliminating the non-dipper phenomenon. According to some authors the non-dipping phenomenon increases cardiovascular risk, while others are of the opinion that the association of non-dipping with cardiovascular events does not necessarily mean that selective treatment of non-dipping improves cardiovascular outcomes.

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“…For example, the onset of non-Qwave angina, unstable angina, myocardial infarctions (MIs), and sudden cardiac death all show marked elevations in the occurrence between the hours of 6:00 AM and 12:00 PM, compared with any other time of day (27,44). A better understanding of the function of circadian genes in the heart and in response to injury may lead to innovative therapies for cardiovascular disease (9,29,46).…”

mentioning

confidence: 99%

Attenuation of myocardial injury in mice with functional deletion of the circadian rhythm gene mPer2

Virag¹,

Dries²,

Easton³

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

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Chronobiology and chronotherapy of ischemic heart disease

Cited by 59 publications

References 127 publications

Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans

Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans

Treatment of Hypertension: Favourable Effect of the Twice-Daily Compared to the Once-Daily (Evening) Administration of Perindopril and Losartan

Attenuation of myocardial injury in mice with functional deletion of the circadian rhythm gene mPer2

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