Chronobiological and morphofunctional aspects of arterial hypertension under circumpolar conditions

Abstract

Introduction. Nowadays the problem of population health in the northern areas is of great importance. While evaluating human adaptation to the extreme geoecological northern conditions the state of the cardiovascular system can be used as an index of effective compensatory adaptation. Study design. The data on 24-hour BP monitoring, data of echocardiography and heliogeophysical factors in different periods of ontogenesis in 317 patients, living in the north of the Tyumen region, were analysed to estimate the morphofunctional and chronobiological peculiarities of arterial hypertension. Results. Considerable disorders of haemodynamic circadian rhythms, manifesting either insufficient decrease of BP at night are revealed in the examined subjects. Above 42.2% of such patients have myocardial hypertrophy. Insufficient night decrease of BP is typical for the examined patients, with coupling of the indices of haemodynamic and current geomagnetic activity. The peculiarities of heliogeophysical factors at early ontogenesis of the examined subjects with an increased variability and decreased circadian index of BP are defined using multivariate analysis. Conclusion. Thus, a combination of disorders of temporary haemodynamic organisation with the morphological changes of myocardium and peculiarities of biogeophysical coupling of the examined is shown. This anthropoecological approach can be used for the diagnostics and treatment of arterial hypertension under conditions of the northern ecosystem.

Heliogeophysical Aspects of Rheology: New Technologies and Horizons of Preventive Medicine

“…The normal functioning of this system provides rate of blood circulation and consequently tissue metabolism, which are optimal for certain conditions. There are studies that consider the effect of heliogeophysical factors: solar activity and disturbances of the geomagnetic field during the study on the state of the cardio-vascular system [8][9][10][11][12][13]. The possibility of influence of heliogeophysical factors in early human ontogenesis on the risk of development of cardiovascular diseases was revealed.…”

Clinical manifestations and risk factors of coronary artery disease in patients with diabetes mellitus in western Siberia

“…It has been shown that greater numbers of circumpolar residents in Russia have systemic hypertension than residents in other regions of the country (1)(2)(3). Diabetes mellitus increases the severity of symptoms caused by coronary artery disease (CAD) in patients with both diseases (4).…”