Chronische mesotympanale Otitis media – Teil 1: Diagnostik &amp; konservative Therapie

Lüdke, Theresa; Müller, Christoph; Zahnert, Thomas

doi:10.1055/a-1961-5714

Cited by 1 publication

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The goal of this review is to provide an overview of the burden of otitis media, including acute infection morbidity, the sequelae of severe and recurring infections, and the costs of the illness, not only in monetary terms for medical and surgical care but also non-medical expenses associated with lost work and higher costs of new drugs needed to manage various infections (not just otitis media) due to multidrug-resistant pathogens resulting from the extensive. [3] ADVANTAGES OF IN SITU GEL [65][66][67][68][69] • On comparing to already formed gel, the main advantage is the ability to administer accurate and reproducible amounts. • Ease of administration.…”

Section: Application Of Poloxamer 407 As Otic Drug Delivery Systemmentioning

confidence: 99%

Untitled

2023

AJP

View full text Add to dashboard Cite

An increasing number of in situ forming systems for many biomedical applications have been published in the literature in recent years. Otitis media (OM), most common condition which is caused due to the infection of virus and bacteria. Otitis media is classified into two types: acute and chronic. The most often isolated pathogens in OM are Streptococcus pneumoniae, non-typeable Haemophilus influenza, and Moraxella catarrhalis. Otalgia, ear drainage, fever, restlessness, earache, headache, mild deafness, and difficulty sleeping are all symptoms of otitis media. The global impact of Chronic Suppurative OM sickness includes up to 330 million people having issue of draining ears, 60% (up to 200 million) have significant hearing difficulty. Thailand had prevalence rates ranging from 0.9 to 4.7%, whereas India has a high frequency of 7.8%. Ear drop has drawbacks such as a shorter residence time frame in the ear. Semisolid preparation includes drawbacks such as administrative complexity. Both of these issues can be solved by developing a solution that forms an in situ gel after administration. Solvent exchange, UV-irradiation, ionic cross-linkage, pH alteration, and temperature modulation are few examples of the mechanisms. Because it does not involve the use of organic solvents, copolymerization agents, or a locally applied gelation trigger, the thermosensitive technique may be desirable for some applications. The benefits of in situ polymeric delivery methods include ease of administration and minimized frequency of administration, in addition to improved patient compliance and comfort. At body temperature, poloxamer 407 aqueous solutions (more than 18% w/v) can produce in situ gel.

show abstract

Section: Application Of Poloxamer 407 As Otic Drug Delivery Systemmentioning

confidence: 99%

Untitled

2023

AJP

View full text Add to dashboard Cite

show abstract

Chronische mesotympanale Otitis media – Teil 1: Diagnostik & konservative Therapie

Cited by 1 publication

References 18 publications

Untitled

Untitled

Contact Info

Product

Resources

About