Chronische Laryngitis und Carcinom

Abstract

35 cases of continuous series of 841 laryngeal cancers were studied separately. Those patients had already been suffering from hoarseness for more than 2 years, in the average for 9 years. Many of these patients had been examined and treated by inhalations, and biopsies were taken because of a chronic laryngitis. Clinically in half of the cases a big carcinoma could be found. In 10 cases a chronic laryngitis had been diagnosed; in spite of the preceeding examination by microlaryngoscopy in 4 cases, however, the carcinoma could only be proved by histologic examination. The histologic examinations of the specimens regularly displayed an extended field of epidermisation of the laryngeal mucosa following chronic laryngitis, In these fields of epidermisation the carcinoma developed multicentrically and--in the early stages--mostly showed a covering-like, minutely infiltrating growth. Disseminated dot-like cancer-focuses in the epidermisation field and cancer buds arising from the basal layers of an intact covering of the hypertrophic epithelium could be observed several times. Chronic-hypertrophic laryngitis seems to favour the development of cancer within some patients (promoting factor), it even might accelerate it. As in about 6% of all the vocal cord cancers a preexistent chronic laryngitis is proved by history and clinical findings each patient with a chronic hypertrophic laryngitis must be examined by microlaryngoscopy as well as histological examinations and must be constantly observed.

Increased risk of laryngeal and pharyngeal cancer after gastrectomy for ulcer disease in a population-based cohort study

“…The anatomical rearrangement after gastrectomy means that duodenal contents easily flows back and can reach the oesophagus, the pharynx, and the larynx. The pharynx and larynx have no defence mechanisms against such proximal reflux, for example, no peristalsis, and such reflux might cause chronic injury and inflammation on the epithelium (Glanz and Kleinsasser, 1976). Tobacco smoking and alcohol consumption, the main risk factors for laryngeal and pharyngeal cancer, might increase the vulnerability of the mucosa for such reflux exposure.…”

No Association between Gastroesophageal Reflux and Cancers of the Larynx and Pharynx

“…The excess risk leveled off after 5 years, however, indicating that this finding might be due to surveillance bias. In 1976, it was first suggested that inflammatory disease could cause laryngeal cancer (23), and in the late 1980s, it was further proposed that gastroesophageal reflux could play a causal role in laryngeal and pharyngeal carcinogenesis (14,17). Until recently, the only available data on this subject were from uncontrolled case series, of which some authors interpreted their data in favor of an association (13)(14)(15)(16)(17), others against (24).…”

Can Bile Acids Be an Etiological Factor for Laryngeal Carcinoma?

“…In 1976, Kleinsasser and Glanz [8] reported the first series of 35 patients with chronic hypertrophic laryngitis that developed laryngeal carcinoma. Ward and Hanson [9] observed the development of laryngeal carcinoma in 19 patients that were nonsmokers, all of which had LFR.…”