Chronicon Paschale 284-628 AD

Whitby, Michael; Whitby, Mary

doi:10.3828/978-0-85323-096-0

Cited by 152 publications

(5 citation statements)

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“…Heme uptake pathways have been discovered in a large number of Gram-negative bacteria, and have been extensively studied in P. aeruginosa, Serratia marscescens, Yersinia pestis, and Haemophilus influenza. [116][117][118][119][120][121][122] Two general mechanisms of heme uptake are found in Gram-negative bacteria. Heme is either acquired through outer membrane receptors that bind host heme and/or heme proteins such as Hb or Hx ( Figures 10A and 10B), 118,[120][121]122 or through the action of secreted heme scavenging proteins called hemophores ( Figure 10C).…”

Section: Heme Uptake In Gram-negative Bacteriamentioning

confidence: 99%

“…[116][117][118][119][120][121][122] Two general mechanisms of heme uptake are found in Gram-negative bacteria. Heme is either acquired through outer membrane receptors that bind host heme and/or heme proteins such as Hb or Hx ( Figures 10A and 10B), 118,[120][121]122 or through the action of secreted heme scavenging proteins called hemophores ( Figure 10C). 116,117,119 After heme has been acquired from the host, it is transported across the bacterial outer membrane using a TonB-dependent outer membrane receptor ( Figure 10).…”

Section: Heme Uptake In Gram-negative Bacteriamentioning

confidence: 99%

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Iron Acquisition in Mycobacterium tuberculosis

Chao¹,

Sieminski²,

Owens

et al. 2018

Chem. Rev.

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The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all human pathogens, Mtb requires iron for growth and virulence. Consequently, Mtb iron transport is an emerging drug target. However, the development of anti-TB drugs aimed at these metabolic pathways have been restricted by the dearth of information on Mtb iron acquisition. In this review, we describe the multiple strategies utilized by Mtb to acquire ferric iron and heme-iron. Mtb iron uptake is a complex process, requiring biosynthesis and subsequent export of Mtb siderophores, followed by ferric iron scavenging and ferric-siderophore import into Mtb. Additionally, Mtb possesses two possible heme uptake pathways, and an Mtb-specific mechanism of heme degradation that yields iron and novel heme-degradation products. We conclude with perspectives for potential therapeutics that could directly target Mtb heme and iron uptake machineries. We also highlight how hijacking Mtb heme and iron acquisition pathways for drug import may facilitate drug transport through the notoriously impregnable Mtb cell-wall.

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Section: Heme Uptake In Gram-negative Bacteriamentioning

confidence: 99%

Section: Heme Uptake In Gram-negative Bacteriamentioning

confidence: 99%

Iron Acquisition in Mycobacterium tuberculosis

Chao¹,

Sieminski²,

Owens

et al. 2018

Chem. Rev.

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“…17,18 More recently, we reported the discovery of Diprovocim, a synthetic small molecule agonist of human and mouse TLR2/TLR1. 19 Identified from a compound library designed to promote cell surface receptor dimerization, 20,21 the precursor of Diprovocim was subjected to extensive structure-activity relationship characterization to improve potency, resulting in an enantiomerically unique drug with twofold symmetry. Diprovocim bears no structural similarity to bacterial triacylated lipoproteins and lipopeptides (e.g., Pam 3 CSK 4 ), the natural ligands for the TLR2/TLR1 heterodimer, or to any other natural or synthetic TLR agonist.…”

Section: Introductionmentioning

confidence: 99%

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim

Wang

et al. 2019

J. Med. Chem.

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Diprovocim is a recently discovered exceptionally potent, synthetic small molecule agonist of TLR2/TLR1 and has shown significant adjuvant activity in anticancer vaccination against murine melanoma. Since Diprovocim bears no structural similarity to the canonical lipopeptide ligands of TLR2/TLR1, we investigated how Diprovocim interacts with TLR2/TLR1 through in vitro biophysical, structural, and computational approaches. We found that Diprovocim induced the formation of TLR2/TLR1 heterodimers as well as TLR2 homodimers in vitro. We determined the crystal structure of Diprovocim in a complex with a TLR2 ectodomain, which revealed, unexpectedly, two Diprovocim molecules bound to the ligand binding pocket formed between two TLR2 ectodomains. Extensive hydrophobic interactions and a hydrogen-bonding network between *

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“…Heraclius'un oğlu genç Heraclius, Phocas'ı 610'da tahttan indirdi ve Phocas'ın 609'da başkent Constantinopolis'te kendi için diktirdiği anıtsal sütunun üzerine bir haç yerleştirdi. 54 Bu sütuna üzerinde Ἕργον θεάρεστον Βασιλέως μεγάλου Ήράκλειοσ ἥδρασεν/Büyük Basileus'un tanrıyı memnun eden eserini, dikti Heraclius" yazısı nakşedilmiş bir de kitabe ekletmişti. 55 Cyril Mango'ya göre bu sütun Constantinus ve Theodosius forumlarının arasında kalan Artopoleia adında ekmek satıcılarının bulunduğu bölgede inşa edilmiş Kırk Şehitler Kilisesi'nin hemen doğusundaki Bronz Tetrapylon'un yakınlarına dikilmişti.…”

Section: [Pr]incipis Hanc Statuam Marciani |Cerne Torumque |[Prae]fec...unclassified

The Column of Phocas and The Icon of Heraclius: Shift from Rome to Byzantium

SALİKOĞLU

2023

Ortaçağ Araştırmaları Dergisi

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Roma İmparatorluğu’nun ne zaman Bizans’a evrildiği konusundaki tartışmaya arkeolojik ve sanat tarihsel kanıtların yardımıyla katkı sağlamak mümkündür. Günümüze ulaşmış birçok arkeolojik ve maddi kanıttan biri de Roma İmparatorluğu’nda neredeyse kesintisiz sürdürülmüş anıtsal sütun dikme geleneğindir. Bu geleneğin son evresi Roma İmparatorluğu’nun Bizans’a evrildiği süreçte önemli bir yere sahiptir. Roma kenti ve bu kentin kalbi Forum Romanum imparatorların diktiği birçok anıtsal sütuna ev sahipliği yapmaktaydı. Başkent Constantinopolis’e taşındığında ve imparatorluk Hristiyanlaştığında dahi bu geleneği hem eski hem de yeni başkentte sürdürmüşlerdi. Bu sütunlar onları Romalı geçmişlerine bağlayan devlet anıtlarıydı. Roma egemenliğini, imparatorun otoritesini, Romalı kimliğini, toplumsal hafızayı ve klasik kültürü temsil etmekteydiler. 7. yy’ın başında İmparator Heraclius bu geleneği terk etti. Onun iktidarı bazı tarihçiler için Roma imparatorluğunun sonu olarak kabul edilir. Bu bir tesadüften ziyade, Heraclius’un içinde yaşadığı dünyanın değişip dönüştüğünün de somut kanıtıydı. Anıtsal sütunlar adeta Roma imparatorluk ideolojisinin kamusal alanda dalgalanan bayrağıydı. İmparatorların anıtsal sütun dikme geleneğini terk etmeleri klasik kültürden ve Roma imparatorluk ideallerinden de kopmak anlamına gelmekteydi. Bu tarihsel durum, bugün Bizans denilen uygarlığın da doğuşuna işaret etmekteydi.

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Chronicon Paschale 284-628 AD

Cited by 152 publications

References 0 publications

Iron Acquisition in Mycobacterium tuberculosis

Iron Acquisition in Mycobacterium tuberculosis

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim

The Column of Phocas and The Icon of Heraclius: Shift from Rome to Byzantium

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