Chronic Zimeldine Administration to Cats: Sustained Increase of Serotonergic Effect as Measured with Sleep Parameters

Sommerfelt, Liv

doi:10.1111/j.1600-0773.1990.tb00718.x

Cited by 6 publications

(1 citation statement)

References 33 publications

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“…With chronic use desensitization of autoreceptors has been reported (Blier Correspondence: Reidun Ursin, Department of Physiology, University of Bergen, Arstadveien 19, N-5009 Bergen, Norway and de Montigny 1983). The net effect is an increased serotonergic effect, but with some tolerance development compared to the effect of acute administration (Sommerfelt 1990).…”

Section: Introductionmentioning

confidence: 99%

Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement

Ursin

Bjorvatn

Sommerfelt

et al. 1992

Journal of Sleep Research

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S U M M A R YStudies with the serotonin uptake inhibitors zimeldine a n d alaproclate show biphasic effects on the sleep/wake axis in rats and cats. Zimeldine induced an initial waking response succeeded by a small SWS-2 increase in rats. T h e waking increase was not blocked by the 5-HT2 antagonist ritanserin nor by t h e putative 5-HT,, antagonist ( -)-alprenolol. In cats, zimeldine induced initial behavioural changes which were succeeded by a large SWS-2 increase. Alaproclate gave similar initial responses as zirneldine in both species, and was succeeded by a moderate sleep increase in cats but not in rats. T h e complex sleep/wake effects following the serotonin uptake inhibitors may result from simultaneous induction of incompatible serotonergic effects.

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Section: Introductionmentioning

confidence: 99%

Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement

Ursin

Bjorvatn

Sommerfelt

et al. 1992

Journal of Sleep Research

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Differential adaptation of REM sleep latency, intermediate stage and theta power effects of escitalopram after chronic treatment

et al. 2012

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The effects of the widely used selective serotonin reuptake inhibitor (SSRI) antidepressants on sleep have been intensively investigated. However, only a few animal studies examined the effect of escitalopram, the more potent S-enantiomer of citalopram, and conclusions of these studies on sleep architecture are limited due to the experimental design. Here, we investigate the acute (2 and 10 mg/kg, i.p. injected at the beginning of the passive phase) or chronic (10 mg/kg/day for 21 days, by osmotic minipumps) effects of escitalopram on the sleep and quantitative electroencephalogram (EEG) of Wistar rats. The first 3 h of EEG recording was analyzed at the beginning of passive phase, immediately after injections. The acutely injected 2 and 10 mg/kg and the chronically administered 10 mg/kg/day escitalopram caused an approximately three, six and twofold increases in rapid eye movement sleep (REMS) latency, respectively. Acute 2-mg/kg escitalopram reduced REMS, but increased intermediate stage of sleep (IS) while the 10 mg/kg reduced both. We also observed some increase in light slow wave sleep and passive wake parallel with a decrease in deep slow wave sleep and theta power in both active wake and REMS after acute dosing. Following chronic treatment, only the increase in REMS latency remained significant compared to control animals. In conclusion, adaptive changes in the effects of escitalopram, which occur after 3 weeks of treatment, suggest desensitization in the function of 5-HT(1A) and 5-HT(1B) receptors.

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Reduced inhibitory potency of serotonin reuptake blockers on central serotoninergic neurons in rats selectively deprived of rapid eye movement sleep

Maudhuit

Jolas

Chastanet

et al. 1996

Biological Psychiatry

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Chronic Zimeldine Administration to Cats: Sustained Increase of Serotonergic Effect as Measured with Sleep Parameters

Cited by 6 publications

References 33 publications

Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement

Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement

Differential adaptation of REM sleep latency, intermediate stage and theta power effects of escitalopram after chronic treatment

Reduced inhibitory potency of serotonin reuptake blockers on central serotoninergic neurons in rats selectively deprived of rapid eye movement sleep

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