Chronic wound healing by controlled release of chitosan hydrogels loaded with silver nanoparticles and calendula extract

Rodríguez-Acosta, Hugo; Rivera, José M. Tapia; Guerrero-Guzmán, Andrea; Hernández-Elizarraráz, Erika; Díaz, José Alfredo; García, Jorge J.O. Garza; Ramírez, Pablo E. Pérez; Ramírez, Sandra Fabiola Velasco; Anguiano, Ana Cristina Ramírez; Juárez, Gilberto Velázquez; López, Jose Miguel Velázquez; Toscano, Yadira G. Sánchez; Morales, Soledad García; Flores-Fonseca, Milagros M.; Bustos, David E. García; Chiprés, David Román Sánchez; Zamudio‐Ojeda, Adalberto

doi:10.1016/j.jtv.2021.10.004

Cited by 35 publications

(19 citation statements)

References 20 publications

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“…Interestingly, in this study, angiogenesis and antimicrobial (against S. aureus or S. epidermidis ) mechanisms concur to the wound healing process, reaching a degree of wound closure of 97% after 14 days. Similarly, antibacterial, and anti-inflammatory activities were analyzed in the evaluation of a multifunctional CH-based hydrogel loaded with Ag nanoparticles and Calendula officinalis L. [ 74 ]. This device was proposed in the treatment of patients with diabetes type II and the recorded results highlighted a significant improvement in both healing on vascular injuries, due to the ability of the patch to stimulate fibrinolysis and healing and reducing the possibility of infection.…”

Section: Polymeric Compoundsmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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Rapid and complete wound healing is a clinical emergency, mainly in pathological conditions such as Type 2 Diabetes mellitus. Many therapeutic tools are not resolutive, and the research for a more efficient remedial remains a challenge. Wound dressings play an essential role in diabetic wound healing. In particular, biocompatible hydrogels represent the most attractive wound dressings due to their ability to retain moisture as well as ability to act as a barrier against bacteria. In the last years, different functionalized hydrogels have been proposed as wound dressing materials, showing encouraging outcomes with great benefits in the healing of the diabetic wounds. Specifically, because of their excellent biocompatibility and biodegradability, natural bioactive compounds, as well as biomacromolecules such as polysaccharides and protein, are usually employed in the biomedical field. In this review, readers can find the main discoveries regarding the employment of naturally occurring compounds and biopolymers as wound healing promoters with antibacterial activity. The emerging approaches and engineered devices for effective wound care in diabetic patients are reported and deeply investigated.

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Section: Polymeric Compoundsmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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“…The quaternized chitosan (QCS) component also has antibacterial ability. In a study by Rodriguez-Acosta et al (2022) , chitosan-based hydrogels loaded with silver nanoparticles and calendula extract (Ch-AgNPs-Ce) were developed, and as in a previous study, these chitosan hydrogels reduced the bacterial load at the wound site.…”

Section: Loaded Componentsmentioning

confidence: 98%

“…The polymers mentioned in this review mainly include oxidized chondroitin sulfate-polypyrrole (OCS-P) ( Fan et al, 2022 ) and dopamine (DA) ( Chi et al, 2022 ) for vascularization; anti-inflammatory bioglass (BG) ( Li S et al, 2022 ) and chitosan ( Lee and Lin, 2022 ); antibacterial carboxymethyl chitosan (CMCS) ( Ji et al, 2022 ), quaternized chitosan (QCS) ( Pan et al, 2022 ), polyaniline-grafted quaternized chitosan (QCS-P) ( Wu J. H et al, 2022 ), and chitosan (CS) ( Rodriguez-Acosta et al, 2022 ); antioxidant polyurethane (PUAO) ( Shiekh et al, 2020 ); and oxidized chondroitin sulfate-polypyrrole (OCS-P) ( Fan et al, 2022 ) and polypyrrole (PPy) ( Liu H et al, 2021 ) for nerve regeneration. From these studies, we can easily see that components such as chitosan have shown powerful effects in antimicrobial therapy and that polypyrrole, as a conducting polymer, showed nerve regeneration and vascularization effects.…”

Section: Loaded Componentsmentioning

confidence: 99%

Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers

Cui

Zhang

Cheng

et al. 2023

Front. Bioeng. Biotechnol.

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Due to recalcitrant microangiopathy and chronic infection, traditional treatments do not easily produce satisfactory results for chronic diabetic ulcers. In recent years, due to the advantages of high biocompatibility and modifiability, an increasing number of hydrogel materials have been applied to the treatment of chronic wounds in diabetic patients. Research on composite hydrogels has received increasing attention since loading different components can greatly increase the ability of composite hydrogels to treat chronic diabetic wounds. This review summarizes and details a variety of newly loaded components currently used in hydrogel composites for the treatment of chronic diabetic ulcers, such as polymer/polysaccharides/organic chemicals, stem cells/exosomes/progenitor cells, chelating agents/metal ions, plant extracts, proteins (cytokines/peptides/enzymes) and nucleoside products, and medicines/drugs, to help researchers understand the characteristics of these components in the treatment of diabetic chronic wounds. This review also discusses a number of components that have not yet been applied but have the potential to be loaded into hydrogels, all of which play roles in the biomedical field and may become important loading components in the future. This review provides a “loading component shelf” for researchers of composite hydrogels and a theoretical basis for the future construction of “all-in-one” hydrogels.

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“…The combination group and laser alone group had statistically better results[ 100 ]. Chitosan based hydrogels loaded with calendula have been studied with promising results[ 101 ].…”

Section: Calendulamentioning

confidence: 99%

Current scenario of traditional medicines in management of diabetic foot ulcers: A review

Rayate¹,

Nagoba²,

Mumbre³

et al. 2023

World J Diabetes

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Diabetic foot infections and diabetic foot ulcers (DFU) cause significant suffering and are often recurring. DFU have three important pathogenic factors, namely, microangiopathy causing local tissue anoxia, neuropathy making the foot prone to injuries from trivial trauma, and local tissue hyperglycaemia favouring infection and delaying the wound healing. DFU have been the leading cause for non-traumatic amputations of part or whole of the limb. Western medicines focus mainly on euglycaemia, antimicrobials, debridement and wound cover with grafts, and off-loading techniques. Advances in euglycaemic control, foot care and footwear, systemic antimicrobial therapy, and overall health care access and delivery, have resulted in an overall decrease in amputations. However, the process of wound care after adequate debridement remains a major cost burden globally, especially in developing nations. This process revolves around two basic concerns regarding control/eradication of local infection and promotion of faster healing in a chronic DFU without recurrence. Wound modulation with various dressings and techniques are often a costly affair. Some aspects of the topical therapy with modern/Western medicines are frequently not addressed. Cost of and compliance to these therapies are important as both the wounds and their treatment are “chronic.” Naturally occurring agents/medications from traditional medicine systems have been used frequently in different cultures and nations, though without adequate clinical base/relevance. Traditional Chinese medicine involves restoring yin-yang balance, regulating the ‘chi’, and promoting local blood circulation. Traditional medicines from India have been emphasizing on ‘naturally’ available products to control wound infection and promote all the aspects of wound healing. There is one more group of chemicals which are not pharmaceutical agents but can create acidic milieu in the wound to satisfy the above-mentioned basic concerns. Various natural and plant derived products ( e.g ., honey, aloe vera, oils, and calendula) and maggots are also used for wound healing purposes. We believe that patients with a chronic wound are so tired physically, emotionally, and financially that they usually accept native traditional medicine which has the same cultural base, belief, and faith. Many of these products have never been tested in accordance to “evidence-based medicine.” There are usually case reports and experience-based reports about these products. Recently, there have been some trials ( in vitro and in vivo ) to verify the claims of usage of traditional medicines in management of DFU. Such studies show that these natural products enhance the healing process by controlling infection, stimulating granulation tissue, antimicrobial action, promoting fibroblastic activity and collagen deposition, etc. In this review, we attempt to study and analyse the available literature on results of topical tradit...

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Chronic wound healing by controlled release of chitosan hydrogels loaded with silver nanoparticles and calendula extract

Cited by 35 publications

References 20 publications

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers

Current scenario of traditional medicines in management of diabetic foot ulcers: A review

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