Chronic widespread pain—the need for a standard definition

Butler, Stephen; Landmark, Tormod; Glette, Mari; Borchgrevink, Petter Chr.; Woodhouse, Astrid

doi:10.1097/j.pain.0000000000000417

Cited by 50 publications

(48 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3,35 There is no Read code for CWP, although the syndrome will be included in the forthcoming International Classification of Diseases , 11th edition. 8 However, although a code does exist for fibromyalgia, the disparity between its estimated community and primary care prevalences suggests that the label of fibromyalgia is not often used in general practice. 10,16 This may reflect the controversial nature of fibromyalgia and CWP, or concern about the wider implications of labeling.…”

Section: Introductionmentioning

confidence: 99%

Identifying patients with chronic widespread pain in primary care

Mansfield

Sim

Croft

et al. 2016

Pain

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Identifying patients with chronic widespread pain in primary care

Mansfield

Sim

Croft

et al. 2016

Pain

View full text Add to dashboard Cite

show abstract

“…Persons with muscular and/or skeletal problems in three or more localizations were categorized as having “widespread musculoskeletal pain” [37]. Those who had one to two localizations for musculoskeletal pain were categorized as having “localized musculoskeletal pain”.…”

Section: Methodsmentioning

confidence: 99%

Are persons with fibromyalgia or other musculoskeletal pain more likely to report hearing loss? A HUNT study

Stranden

Solvin

Fors

et al. 2016

BMC Musculoskelet Disord

View full text Add to dashboard Cite

BackgroundLeading theories about the pathogenesis of fibromyalgia focus on central nervous dysregulation or sensitization, which can cause altered perception. There is growing evidence that fibromyalgia involves altered perception not only of pain, but also other sensory stimuli. On this basis, we investigated whether individuals with fibromyalgia are more likely to report subjective loss of hearing, adjusted for audiometrically measured loss of hearing, compared to persons without any musculoskeletal pain disorders. In addition, we studied persons with other musculoskeletal pain than fibromyalgia and persons who did not have any musculoskeletal pain.MethodsThe study includes 44 494 persons from the second health survey in Nord-Trøndelag (HUNT2) who had undergone audiometry and answered a comprehensive questionnaire that mapped fibromyalgia, musculoskeletal pain at various sites and subjective hearing loss. Respondents with other musculoskeletal pain problems than fibromyalgia were divided into two groups with respectively localized and widespread musculoskeletal pain. Data were analyzed with logistic regression models adjusting for age, education, anxiety, depression and hearing thresholds.ResultsIn adjusted analysis, individuals with fibromyalgia had increased likelihood to report subjective hearing loss, compared to persons without fibromyalgia or other musculoskeletal pain (OR 4.578, 95% CI 3.622–5.787 and OR 4.523, 95% CI 3.077–6.647 in women and men). Furthermore, people with local and widespread musculoskeletal pain not diagnosed with fibromyalgia, also had increased likelihood to report subjective hearing loss, compared to people with no musculoskeletal pain. This relationship was greater for widespread pain than for localized pain (OR 1.915, 95% CI 1.627–2.255, and 1.796, 95% CI 1.590–2.029, in women and men with local musculoskeletal pain and OR 3.073, 95% CI 2.668-3.539, OR 3.618, 95% CI 3.225–4.058, in women and men with widespread pain, respectively).ConclusionsOur findings are consistent with the hypothesis that fibromyalgia is related to a general dysregulation of the central nervous system. The same might also be the case for other local and, in particular, other widespread, musculoskeletal pain.

show abstract

“…The newly proposed version 11 of the International Classification of Diseases (ICD-11) identifies CWP as the first diagnosis under the category “chronic primary pain” 9. Different alterations in the central processing of nociception (e.g., central hyperexcitability), descending facilitation, impairment of descending inhibition, and biochemical and functional alterations in networks (e.g., default mode network) of the brain are present in CWP/FMS 10–13.…”

Section: Introductionmentioning

confidence: 99%

Clear differences in cerebrospinal fluid proteome between women with chronic widespread pain and healthy women – a multivariate explorative cross-sectional study

Olausson

Ghafouri

Bäckryd

et al. 2017

JPR

View full text Add to dashboard Cite

IntroductionFrequent chronic local pain can develop into chronic widespread pain (CWP). The spread of pain is correlated with pain intensity, anxiety, and depression, conditions that ultimately lead to a poor quality of life. Knowledge is incomplete about CWP’s etiology, although it has been suggested that both central hyperexcitability and/or a combination with peripheral factors may be involved. Cerebrospinal fluid (CSF) could act as a mirror for the central nervous system as proteins are signal substances that activate the formation of algesics and control nociceptive processes. To this end, this study investigates the CSF protein expression in women with CWP and in female healthy controls.Materials and methodsThis study included 12 female patients with CWP diagnosed according to the American College of Rheumatology criteria with 13 healthy age- and sex-matched pain-free subjects. All subjects went through a clinical examination and answered a health questionnaire that registered sociodemographic and anthropometric data, pain characteristics, psychological status, and quality of life rating. CSF was collected by lumbar puncture from each subject. Two-dimensional gel electrophoresis in combination with mass spectrometry was used to analyze the CSF proteome. This study identifies proteins that significantly discriminate between the two groups using multivariate data analysis (MVDA) (i.e., orthogonal partial least squares discriminant analysis [OPLS-DA]).ResultsThere were no clinically significant levels of psychological distress and catastrophization presented in subjects with CWP. MVDA revealed a highly significant OPLS-DA model where 48 proteins from CSF explained 91% (R2) of the variation and with a prediction of 90% (Q2). The highest discriminating proteins were metabolic, transport, stress, and inflammatory.ConclusionThe highest discriminating proteins (11 proteins), according to the literature, are involved in apoptotic regulations, anti-inflammatory and anti-oxidative processes, the immune system, and endogenous repair. The results of this explorative study may indicate the presence of neuro-inflammation in the central nervous system of CWP patients. Future studies should be larger and control for confounders and determine which alterations are unspecific/general and which are specific changes.

show abstract

Chronic widespread pain—the need for a standard definition

Cited by 50 publications

References 23 publications

Identifying patients with chronic widespread pain in primary care

Identifying patients with chronic widespread pain in primary care

Are persons with fibromyalgia or other musculoskeletal pain more likely to report hearing loss? A HUNT study

Clear differences in cerebrospinal fluid proteome between women with chronic widespread pain and healthy women – a multivariate explorative cross-sectional study

Contact Info

Product

Resources

About

Chronic widespread pain—the need for a standard definition

Cited by 50 publications

References 23 publications

Identifying patients with chronic widespread pain in primary care

Identifying patients with chronic widespread pain in primary care

Are persons with fibromyalgia or other musculoskeletal pain more likely to report hearing loss? A HUNT study

Clear differences in cerebrospinal fluid proteome between women with chronic widespread pain and healthy women &ndash; a multivariate explorative cross-sectional study

Contact Info

Product

Resources

About

Clear differences in cerebrospinal fluid proteome between women with chronic widespread pain and healthy women – a multivariate explorative cross-sectional study