Chronic viral coinfections differentially affect the likelihood of developing long COVID

Peluso, Michael J.; Deveau, Tyler-Marie; Munter, Sadie E.; Ryder, Dylan; Buck, Amanda M.; Beck-Engeser, Gabriele; Chan, Fay; Lu, Scott; Goldberg, Sarah A; Hoh, Rebecca; Tai, Viva; Torres, Leonel; Iyer, Nikita S.; Deswal, Monika; Ngo, Lynn H; Buitrago, Melissa; Rodríguez, A. E.; Chen, Jessica Y.; Yee, Brandon C; Chenna, Ahmed; Winslow, John; Petropoulos, Christos J.; Deitchman, Amelia N.; Hellmuth, Joanna; Spinelli, Matthew A; Durstenfeld, Matthew S; Hsue, Priscilla Y.; Kelly, John D.; Martin, Jeffrey N.; Deeks, Steven G.; Hunt, P.; Henrich, Timothy J.

doi:10.1172/jci163669

Cited by 115 publications

(92 citation statements)

References 64 publications

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“…The reactivation of the Epstein–Barr virus and the human immunodeficiency virus (HIV) were associated with fatigue symptoms and neurocognitive changes, in addition to symptoms of post-traumatic stress and functional impairment. The immune system and organ tissue damage may contribute to long-term COVID-19 [ 24 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Symptoms after Mild Coronavirus Disease in Healthy Healthcare Professionals: A 12-Month Prospective Cohort Study

Silva

Moura

Santos

et al. 2023

IJERPH

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The coronavirus disease 2019 (COVID-19) pandemic has changed the course of human history and killed millions of people worldwide. Its long-term consequences remain uncertain. This study aimed to describe the short- and long-term symptoms of COVID-19 among individuals in Goiás, central Brazil, who experienced acute mild or non-symptomatic SARS-CoV-2 infection during the first wave of the pandemic. This prospective cohort study included 110 healthcare workers, 18 safety workers, and 19 administrative support workers, who were followed up for 12 months after the onset of COVID-19. Most participants were healthy adult female healthcare professionals. At the onset of infection, the major symptoms were headache, myalgia, nasal congestion, cough, coryza, anosmia, ageusia, sore throat, fatigue, diarrhea, and dyspnea. Furthermore, 20.3% of the participants had three or more COVID-19 symptoms that persisted for at least 12 months. These included coryza, congestion, hair loss, sore throat, headache, myalgia, cough, memory loss, anosmia, and fatigue. This study revealed a high prevalence of persistent symptoms of COVID-19 in healthy individuals from central Brazil, which may present an additional burden on healthcare services. Further studies are required to investigate the sequelae of COVID-19 over periods greater than 12 months.

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Section: Discussionmentioning

confidence: 99%

Long-Term Symptoms after Mild Coronavirus Disease in Healthy Healthcare Professionals: A 12-Month Prospective Cohort Study

Silva

Moura

Santos

et al. 2023

IJERPH

View full text Add to dashboard Cite

show abstract

“…There is also emerging evidence for latent herpesviruses reactivation in people with long COVID. Reactivation of latent Epstein-Barr virus, but not the acute mononucleosis infection, is found in people with long COVID, 4 , 6 and Epstein-Barr virus viraemia at the time of acute COVID is predictive for long COVID. 5 …”

mentioning

confidence: 91%

Why we need a deeper understanding of the pathophysiology of long COVID

Iwasaki¹,

Putrino²

2023

The Lancet Infectious Diseases

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“…At the more extreme end of the spectrum of impairment, some individuals with long COVID meet the diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) [ 5 , 6 , 7 ]. The risk factors for developing long COVID are emerging but are incomplete at this time, although female sex is a common risk factor for both ME/CFS and long COVID [ 8 , 9 , 10 ]. The optimal treatment for post-COVID conditions remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

A Case Study of Successful Application of the Principles of ME/CFS Care to an Individual with Long COVID

et al. 2023

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Persistent fatigue is one of the most common symptoms of post-COVID conditions, also termed long COVID. At the extreme end of the severity spectrum, some individuals with long COVID also meet the criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), raising the possibility that symptom management approaches for ME/CFS may benefit some long COVID patients. We describe the long-term outcomes of a 19-year-old male who developed profound impairment consistent with ME/CFS after a SARS-CoV-2 infection early in the pandemic. We evaluated and treated him using our clinic’s approach to ME/CFS. This included a history and physical examination that ascertained joint hypermobility, pathological reflexes, physical therapy maneuvers to look for a range of motion restrictions in the limbs and spine, orthostatic testing, and screening laboratory studies. He was found to have profound postural tachycardia syndrome, several ranges of motion restrictions, and mast cell activation syndrome. He was treated according to our clinic’s guidelines for managing ME/CFS, which included manual physical therapy maneuvers and both non-pharmacologic measures and medications directed at postural tachycardia syndrome and mast cell activation. He experienced significant improvement in his symptoms over 30 months. His case emphasizes how the application of the principles of treating ME/CFS has the potential to provide a direction for treating long COVID.

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Chronic viral coinfections differentially affect the likelihood of developing long COVID

Cited by 115 publications

References 64 publications

Long-Term Symptoms after Mild Coronavirus Disease in Healthy Healthcare Professionals: A 12-Month Prospective Cohort Study

Long-Term Symptoms after Mild Coronavirus Disease in Healthy Healthcare Professionals: A 12-Month Prospective Cohort Study

Why we need a deeper understanding of the pathophysiology of long COVID

A Case Study of Successful Application of the Principles of ME/CFS Care to an Individual with Long COVID

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