2011
DOI: 10.1152/ajprenal.00478.2010
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Chronic vasodilation produces plasma volume expansion and hemodilution in rats: consequences of decreased effective arterial blood volume

Abstract: Fekete A, Sasser JM, Baylis C. Chronic vasodilation produces plasma volume expansion and hemodilution in rats: consequences of decreased effective arterial blood volume. Am J Physiol Renal Physiol 300: F113-F118, 2011. First published October 27, 2010 doi:10.1152/ajprenal.00478.2010 expansion is required for optimal pregnancy outcomes; however, the mechanisms responsible for sodium and water retention in pregnancy remain undefined. This study was designed to test the "arterial underfill hypothesis" of pregnan… Show more

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Cited by 12 publications
(9 citation statements)
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References 37 publications
(42 reference statements)
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“…NIF increased PDE5A protein abundance in the renal IM (as reported previously) (10), and this increase persisted when SPR was also administered. No changes were observed in PDE5A protein abundance in the OM or CTX of NIF or NIF ϩ SPR-treated animals ( Fig.…”
Section: Mapsupporting
confidence: 86%
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“…NIF increased PDE5A protein abundance in the renal IM (as reported previously) (10), and this increase persisted when SPR was also administered. No changes were observed in PDE5A protein abundance in the OM or CTX of NIF or NIF ϩ SPR-treated animals ( Fig.…”
Section: Mapsupporting
confidence: 86%
“…*P Ͻ 0.05 vs. CON. the vasculature, as well as increased PDE5A protein abundance in medulla (10). The similarity in medullary responses to these two structurally and mechanistically diverse vasodilators suggests that it is vasodilation "per se" that initiates these renal changes.…”
Section: Discussionmentioning
confidence: 99%
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“…In 4-mo-old rats, radio transmitters (no. HD-S10; Data Sciences International; St. Paul, MN) were implanted in the left femoral artery, as we previously described (12). Carprofen was administered subcutaneously for up to 2 days postsurgery.…”
Section: Animalsmentioning
confidence: 99%