Chronic variable stress and intravenous methamphetamine self-administration – Role of individual differences in behavioral and physiological reactivity to novelty

Taylor, Sara B.; Watterson, Lucas R.; Kufahl, Peter R.; Nemirovsky, Natali E.; Tomek, Seven E.; Conrad, Cheryl D.

doi:10.1016/j.neuropharm.2016.05.003

Cited by 9 publications

(5 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data is supported by recent findings from another institution, in which construction occurring in close proximity to an animal facility was shown to alterrenin-angiotensin system activity and stress hormones at multiple levels of the hypothalamic-pituitary-adrenal axis [15]. In addition, stress history and novel environmental conditions have been shown to be predictive of patterns of METH taking in rodents [16].Together, these observations underscore the impact that different types of stressors and the timing in which they are experienced can have on drug intake in animal studies, and highlight the importance of environmental stimuli in experiments of this type. Translating these findings to human drug use behavior will require further studies, but stress has been established as a contributing factor to relapse as well as the development and persistence of addiction in humans, as reviewed recently [17].…”

supporting

confidence: 89%

Intermittent Vibration Increases Methamphetamine Intake in Rats

Gosselink¹

2016

ADSD

View full text Add to dashboard Cite

It is known that drug-taking behavior can be influenced by a user's physical and social environment, as well as their history. When using animal models in the study of substance use, changes to the microenvironment of the cage (i.e., access to food and water, bedding, number of animals housed per cage, air exchange, enrichment) or the macroenvironment of the vivarium (i.e., light cycle, humidity, temperature) may affect experimental outcomes [1]. Ambient noise and vibration levels are also a concern, and must be taken into consideration when designing facilities and conducting experiments as noise volumes in excess of 85 decibels have been shown to affect behavioral *Corresponding author: Kristin L Gosselink, Department of Biological Sciences, The University of Texas at El Paso, 500 W University Ave, El Paso, TX 79902, USA, Tel: +1 9157476877; E-mail: kgosselink@utep.edu and physiological outcomes including fertility [2] and adrenal weight [3]. Rodents are also sensitive to ultrasonic sounds, which at high frequencies can affect locomotor behavior [4]. Likewise, vibrational stimuli of varying duration, intensity and frequency that originate from within the vivarium or from external sources can modify animal behavior and biology [5,6] and should thus be minimized as much as possible. A recent study [7] has provided evidence that even anesthetized rodents may be subject to the effects of vibration.Numerous studies have used loud noise as a stress stimulus, and demonstrated increases in stress hormones such as epinephrine and cortisol that are then implicated in the manifestation of stress-associated physiological disorders [8]. Whole-body vibration can alter autonomic and neuroendocrine responses to stress, by increasing the limbic secretion of factors that regulate hypothalamic-pituitary function such as vasoactive intestinal peptide [9] and substance-P or neurotensin [10]. In a separate study, whole-body vibrational stress decreased norepinephrine levels in whole brain as well as in the hypothalamus and hippocampus [11]. Fewer investigations into the effects of noise or vibration on drug intake have been published. However, one study found that conditioned place preference to MDMA (3,4-methylenedioxymethamphetamine; "ecstasy") was enhanced by exposure to noise in rats [12]. Paradoxically, loud noise was shown to enhance MD-MA-induced toxicity in nigrostriatal dopaminergic terminals in mice [13], and the combination of Methamphetamine (METH) and loud noise in mice has been shown to increase the number of seizures and the amount of reactive gliosis in the brain compared to METH alone [14]. In summary, the ability of vibration or noise to serve as stressors in animal studies is clear and the eradication of these stimuli is critical for effective experimental design and analysis. This is especially true in studies where stress is applied as an independent variable or measured as an outcome of the experimental design.We recently conducted a study on METH Intravenous Self-Administration (IVSA) in young adult male rats...

show abstract

supporting

confidence: 89%

Intermittent Vibration Increases Methamphetamine Intake in Rats

Gosselink¹

2016

ADSD

View full text Add to dashboard Cite

show abstract

“…We show in the present study that locomotor response to novelty predicts drinking after 48 h of deprivation (here termed the “deprivation effect,” see Figure 4C ). Response to novelty in rodents is well established as a predictor of psychostimulant self‐administration, 40 , 41 , 42 such that “high responders” acquire self‐administration of drugs more rapidly than “low responders.” Likewise, in humans, measures of sensation seeking are linked with drug and alcohol use. 43 , 44 Prior work in DAT+/− rats demonstrate in home cage, or in long or repeated sessions in the open field, that general locomotor activity does not differ from DAT+/+ animals.…”

Section: Discussionmentioning

confidence: 99%

Patterns of ethanol intake in male rats with partial dopamine transporter deficiency

Kuiper

Roberts

Estave

et al. 2023

Genes Brain and Behavior

View full text Add to dashboard Cite

Mesolimbic dopamine signaling plays a major role in alcohol and substance use disorders as well as comorbidities such as anxiety and depression. Growing evidence suggests that alcohol drinking is modulated by the function of the dopamine transporter (DAT), which tightly regulates extracellular dopamine concentrations. Adult male rats on a Wistar Han background (DAT+/+) and rats with a partial DAT deletion (DAT+/−) were used in this study. First, using fast‐scan cyclic voltammetry in brain slices containing the nucleus accumbens core from ethanol‐naïve subjects, we measured greater evoked dopamine concentrations and slower dopamine reuptake in DAT+/− rats, consistent with increased dopamine signaling. Next, we measured ethanol drinking using the intermittent access two‐bottle choice paradigm (20% v/v ethanol vs. water) across 5 weeks. DAT+/− rats voluntarily consumed less ethanol during its initial availability (the first 30 min), especially after longer periods of deprivation. In addition, DAT+/− males consumed less ethanol that was adulterated with the bitter tastant quinine. These findings suggest that partial DAT blockade and concomitant increase in brain dopamine levels has potential to reduce drinking and ameliorate alcohol use disorder (AUD).

show abstract

“…Preclinical evidence supports the moderating role of general startle reactivity: stressor exposure increased methamphetamine-seeking behavior and use in rats but only for animals identified as high-reactivity based on behavioral tests (Taylor et al, 2016). In humans, general startle reactivity predicts stressor response to predictable and unpredictable stressors (Bradford, Kaye, et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…However, there is not yet clear evidence as to whether sex moderates stress allostasis among individuals who use drugs (Fronk et al, 2020). Stable individual differences in stress reactivity may also predict or moderate stress allostasis in animals (Taylor et al, 2016) and in humans (Bradford, Kaye, et al, 2014; Bradford et al, 2013; Hogle et al, 2010).…”

mentioning

confidence: 99%

Central stress response among deprived and continuing marijuana users and nonusers.

Fronk¹,

Hefner²,

Gloria³

et al. 2022

Psychology of Addictive Behaviors

View full text Add to dashboard Cite

Objective: We examined central nervous system [CNS] stress responses among deprived and continuing heavy marijuana users and nonusers. Method: Participants (N = 210; 46.7% female; M age = 21.99; 91.4% White, 94.3% Non-Hispanic) were heavy marijuana users (N = 134) and nonusers (N = 76). Heavy users were randomly assigned to a 3-day marijuana deprivation condition (N = 68) or to continue using regularly (N = 66). Participants completed two threat-of-shock stressor tasks that manipulated stressor predictability by varying shock probability or timing. We measured central stress responses via startle potentiation (stressor conditions minus matched no-stressor condition). We examined two group contrasts (heavy use: all heavy users vs. nonusers; deprivation: deprived vs. continuing heavy users) on startle potentiation overall and moderated by stressor predictability (unpredictable vs. predictable). Results: Deprivation did not affect startle potentiation overall (timing task: p = .184; probability task: p = .328) or differently by stressor predictability (timing task: p = .147; probability task: p = .678). Heavy use did not affect startle potentiation overall (timing task: p = .213; probability task: p = .843) or differently by stressor predictability (timing task: p = .655; probability task: p = .273). Posthoc analyses showed mixed evidence of general startle reactivity × deprivation interaction on startle potentiation overall (timing task: p = .019; probability task: p = .056) and differently by stressor predictability (probability task: p = .024; timing task: p = .364). Conclusions: A history of marijuana use or acute deprivation did not alter central stress responses despite prominent theoretical expectations. This study adds to growing research on central stress responses in individuals with a history of drug use and begins to parse moderating roles of individual differences and stressor characteristics. Public Health Significance StatementIndividuals with a history of drug use have been theorized to display atypical stress responses. This study does not find evidence of altered CNS stress responses when comparing heavy marijuana users to nonusers or when comparing continuing marijuana users to acutely deprived marijuana users. Expanding research to include naturalistic stressors, more stressor characteristics, and multisystemic responses may improve understanding of stress mechanisms in substance use disorders and offer paths forward for theory refinement and treatment.

show abstract

Chronic variable stress and intravenous methamphetamine self-administration – Role of individual differences in behavioral and physiological reactivity to novelty

Cited by 9 publications

References 64 publications

Intermittent Vibration Increases Methamphetamine Intake in Rats

Intermittent Vibration Increases Methamphetamine Intake in Rats

Patterns of ethanol intake in male rats with partial dopamine transporter deficiency

Central stress response among deprived and continuing marijuana users and nonusers.

Contact Info

Product

Resources

About