Chronic use of indinavir in albino rat pregnancy (Rattus norvegicus albinus, Rodentia, Mammalia): Biological assay

Quintino, Marisa Pascale; Nakamura, Mary Uchiyama; Simões, Manuel de Jesus; Filho, Ricardo Martins de Oliveira; Torloni, Maria Regina; Espiridião, Silvia; Júnior, Luiz Kulay

doi:10.1111/j.1447-0756.2010.01504.x

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…0857/09), and procedures were carried out in compliance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The study design followed the research protocol developed at the Obstetric Department of this university [25][26][27].…”

Section: Methodsmentioning

confidence: 99%

Effects of Chronic Bryophyllum pinnatum Administration on Wistar Rat Pregnancy

Hosomi

Ghelman²,

Quintino³

et al. 2014

Complement Med Res

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Background: Drugs used in preterm labor (PTL) have side effects. Research into new tocolytic agents is recommended. The plant Bryophyllum pinnatum (Lam.) Oken (Kalanchoe pinnata (Lam.) Pers) is used in Anthroposophic Medicine for PTL, insomnia, and emotional disturbances. The aim of this study was to evaluate the effects of B. pinnatum mother tincture (MT) on Wistar rats and their fetuses throughout pregnancy. Method: Sixty animals were divided into 6 equal groups: controls C1 and C2 received 1 and 25 × the maximum daily dose of a 30% ethanol / water solution, serving as vehicle of B. pinnatum MT; B1 and B2 received 1 and 25 × the maximum daily dose of B. pinnatum MT; and B3 and B4 received 50 and 100 × B. pinnatum concentrate. The following parameters were assessed: weight gain; maternal and fetal mortality; implantations and resorptions; number and weight of fetuses and placentas; major external fetal malformations. Results: Rat weight gain (excluding fetal and placental weight) was higher in group B4 and lower in group B2. There were no maternal or fetal deaths and no group differences in implantations and resorptions or number and weight of fetuses and placentas. No macroscopic fetal abnormalities were observed at the 4 dosage levels investigated. Conclusion: Daily administration of B. pinnatum MT at high doses to pregnant Wistar rats interfered with maternal weight gain and did not interfere with fetal compartment.

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Section: Methodsmentioning

confidence: 99%

Effects of Chronic Bryophyllum pinnatum Administration on Wistar Rat Pregnancy

Hosomi

Ghelman²,

Quintino³

et al. 2014

Complement Med Res

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HIV Protease Inhibitors in Pregnancy

Andany

Loutfy

2013

Drugs

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The impact of antiretroviral therapy (ART) on the natural history of HIV-1 infection has resulted in dramatic reductions in disease-associated morbidity and mortality. Additionally, the epidemiology of HIV-1 infection worldwide is changing, as women now represent a substantial proportion of infected adults. As more highly effective and tolerable antiretroviral regimens become available, and as the prevention of mother-to-child transmission becomes an attainable goal in the management of HIV-infected individuals, more and more HIV-positive women are choosing to become pregnant and have children. Consequently, it is important to consider the efficacy and safety of antiretroviral agents in pregnancy. Protease inhibitors are a common class of medication used in the treatment of HIV-1 infection and are increasingly being used in pregnancy. However, several studies have raised concerns regarding pharmacokinetic alterations in pregnancy, particularly in the third trimester, which results in suboptimal drug concentrations and a theoretically higher risk of virologic failure and perinatal transmission. Drug level reductions have been observed with each individual protease inhibitor and dose adjustments in pregnancy are suggested for certain agents. Furthermore, studies have also raised concerns regarding the safety of protease inhibitors in pregnancy, particularly as they may increase the risk of pre-term birth and metabolic disturbances. Overall, protease inhibitors are safe and effective for the treatment of HIV-infected pregnant women. Specifically, ritonavir-boosted lopinavir- and atazanavir-based regimens are preferred in pregnancy, while ritonavir-boosted darunavir- and saquinavir-based therapies are reasonable alternatives. This paper reviews the use of protease inhibitors in pregnancy, focusing on pharmacokinetic and safety considerations, and outlines the recommendations for use of this class of medication in the HIV-1-infected pregnant woman.

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Comparação entre as frequências baixa e alta da estimulação elétrica nervosa transcutânea na prenhez da camundonga Swiss

Yokoyama¹

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Agradecer a Deus. Aos meus pais, Lucia e Tiyoshi que sempre me deram fé, discernimento e motivação nesta longa caminhada educacional que vem sendo construída desde a minha infância. Aos meus irmãos, Gustavo e Vinícius, e cunhadas, Mônica e Maki, pelo apoio, paciência e carinho. Ao meu noivo, Renato Habara, com muita paciência, amor e carinho, me ensinou que, por maior que sejam os problemas, nunca se deve desistir, pois são passageiros e transponíveis. A coragem de enfrentá-los deve prevalecer sempre. A todos os membros da família Kato, Harakawa, Yokoyama, Kawashima, Yamada, Momii e Habara onde, em todas as reuniões familiares, sempre me incentivaram com palavras carinhosas e construtivas. À minha orientadora Profa. Dra. Raquel Aparecida Casarotto, o meu maior agradecimento por toda a disponibilidade e orientação prestada, pelo apoio incondicional e compreensão que sempre manifestou. Aos meus amigos, Luiz Afonso Pires, Nidiara Sayuri Sassaki, Marcel Yuzo Oshikawa, David e Ivan que me ajudaram a realizar esse projeto com muita paciência e dedicação. A todos os meus amigos e amigas que me encorajaram e me ajudaram a produzir algo de valor em minha vida. A minha querida prima, Cristiane Yukie, que sempre me apoiou com palavras sinceras. A minha insubstituível amiga, Lana, que sempre esteve presente nessa longa jornada. Aos meus amigos do ShinZushi e a Miyuki San, pela paciência e compreensão. Normatização adotada Esta dissertação está de acordo com as seguintes normas, em vigor no momento desta publicação: Referências: adaptado de International Committee of Medical Journals Editors (Vancouver).

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Chronic use of indinavir in albino rat pregnancy (Rattus norvegicus albinus, Rodentia, Mammalia): Biological assay

Abstract: Chronic use of various dosages of indinavir during pregnancy was not associated significant adverse outcomes.

Cited by 3 publications

References 28 publications

Effects of Chronic <b><i>Bryophyllum pinnatum</i></b> Administration on Wistar Rat Pregnancy

Effects of Chronic <b><i>Bryophyllum pinnatum</i></b> Administration on Wistar Rat Pregnancy

HIV Protease Inhibitors in Pregnancy

Comparação entre as frequências baixa e alta da estimulação elétrica nervosa transcutânea na prenhez da camundonga Swiss

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