Chronic urticaria and hormones: Is there a link?

Amsler, E.; Augey, F.; Soria, Angèle; Boccon‐Gibod, Isabelle; Doutre, M.-S.; Mathelier‐Fusade, P.; Nicolas, Jean‐François; Rayson-Peyron, N.; Gompel, Anne

doi:10.1111/jdv.13644

Cited by 19 publications

(18 citation statements)

References 14 publications

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“…In a cross‐sectional study that included interviewing 200 women with CU, it was observed that the disease occurred more often after the puberty and it worsened in four of 16 women during pregnancy, whereas hormonal contraception exacerbated CSU in 10% . The authors concluded that sex hormones act as a trigger in only a small subset of women with CU.…”

Section: Resultsmentioning

confidence: 99%

“…In a cross-sectional study that included interviewing 200 women with CU, it was observed that the disease occurred more often after the puberty and it worsened in four of 16 women during pregnancy, whereas hormonal contraception exacerbated CSU in 10%. 15 The authors concluded that sex hormones act as a trigger in only a small subset of women with CU. CSU exacerbated by oestrogens should be distinguished from hereditary angio-oedema type III, which is oestrogen-dependent, and is associated with normal levels of C1 inhibitor.…”

Section: Clinical Markers Of Severity and Time To Remissionmentioning

confidence: 99%

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Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Sánchez‐Borges

Caballero‐Fonseca

Capriles‐Hulett

et al. 2017

Acad Dermatol Venereol

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Biomarkers useful for the evaluation and management of patients with chronic spontaneous urticaria (CSU) are not currently available. A review of various clinical and laboratory markers that have been studied to assess their value for determining the severity or predicting the evolution of disease in adult patients with CSU was carried out. A search of the medical literature on PubMed and MEDLINE including the terms urticaria, chronic urticaria, chronic idiopathic urticaria, CSU, severity, prognosis and treatment was performed. Based on our review of the literature, among the clinical markers studied, higher age at onset, being female, long disease duration and aspirin/NSAID hypersensitivity may be linked to both severe CSU and a long time to spontaneous remission. In addition, a positive autologous serum skin test (ASST) may be associated with severe CSU, and comorbidity of inducible urticaria and concomitant recurrent angio-oedema may be linked to longer CSU duration. Potential biomarkers of CSU severity and/or duration include basophil numbers and susceptibility to activation, inflammatory markers, markers of activation of the extrinsic coagulation pathway, immunoglobulin E and vitamin D. Although the described markers are promising, further studies on representative and well-characterized patient populations are needed to determine the value of these clinical and biological markers for predicting the severity and course of disease in patients with CSU.

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Section: Resultsmentioning

confidence: 99%

Section: Clinical Markers Of Severity and Time To Remissionmentioning

confidence: 99%

Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Sánchez‐Borges

Caballero‐Fonseca

Capriles‐Hulett

et al. 2017

Acad Dermatol Venereol

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“…Epidemiological studies showed that most CSU patients are females between 20 and 59 years old and being female seems to be a predictor of longer time of remission and quality of life impairment 89,92,93. Although studies are limited, it appears that sex hormones could play a role as triggers of the disease in a small subset of patients 94. Most of the women studied did not experience CU before puberty; worsening symptoms was observed in a small group of pregnant women during urticaria, and hormonal contraception was associated with aggravation of symptoms in a minority of women 94.…”

Section: Clinical Biomarkersmentioning

confidence: 99%

“…Although studies are limited, it appears that sex hormones could play a role as triggers of the disease in a small subset of patients 94. Most of the women studied did not experience CU before puberty; worsening symptoms was observed in a small group of pregnant women during urticaria, and hormonal contraception was associated with aggravation of symptoms in a minority of women 94. Furthermore, a decreased serum concentration of dehydroepiandrosterone sulphate (DHEA-S) was observed in CSU patients, with levels significantly lower in symptomatic patients than in disease remission 95,96.…”

Section: Clinical Biomarkersmentioning

confidence: 99%

<p>Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications</p>

Puxeddu¹,

Petrelli²,

Angelotti³

et al. 2019

JAA

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Chronic urticaria (CU) is a mast cell-driven disease characterized by the development of wheals, angioedema, or both for more than 6 weeks. The two major sub-types are chronic spontaneous urticaria (CSU) and inducible urticaria. In the last decade different pathophysiological mechanisms, potentially responsible for the development of the disease, have been described. It is likely that the activation of mast cells and basophils in CSU can be the results of immune system dysregulation, activation of the inflammatory cascade, and of the extrinsic coagulation pathway. Some of the mediators involved in the pathophysiological mechanisms of CSU have recently been identified as potential biomarkers useful for the diagnosis, follow-up, and management of the disease, even if they are not yet available in clinical practice. Thus, in this review we discuss new insights in the mediators involved in the pathogenesis of CSU, highlighting their potential role as biomarkers in the activity and progression of the disease and response to therapies.

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“…Different studies have described different clinical markers of severity and prognosis; few datasets show how age could be inversely associated with disease severity; the less old the patient is, the less severe the disease [2]. Being female seems to be a predictor of longer time to remission [26] and quality of life impairment [27]; in fact, as demonstrated by Amsler et al, urticaria onset occurs more often after puberty, is worsened by pregnancy, and could be reactivated by hormonal contraception [28]. However, the authors do not describe sex hormones as a pathogenic factor but only as a strong trigger in a small subset of patients [28].…”

Section: Severity and Prognosismentioning

confidence: 99%

Cutting Edge: Biomarkers for Chronic Spontaneous Urticaria

Folci

Heffler

Canonica

et al. 2018

Journal of Immunology Research

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Chronic spontaneous urticaria (CSU) is defined by the appearance of wheals and a variable presence of angioedema which persists for at least 6 weeks. It represents the most common subtype of chronic urticaria and is gaining importance in civil society because of its association with impaired quality of life. Moreover, CSU has a growing impact on national health systems representing a great burden due to its variable rate of response to the approved therapies. In this scenario, the identification of clinical and molecular biomarkers is of pivotal importance. Some groups are trying to detect molecules which would be able to help clinicians in reaching a proper diagnosis; additionally, the opportunity to describe disease severity which leads to cluster patients in different groups could fill the gap in the numerous unmet clinical needs. Several biomarkers are currently being studied with the purpose to predict the response to a defined therapy; unfortunately, none of them are ready to be translated from bench to bedside.

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Chronic urticaria and hormones: Is there a link?

Abstract: It would appear that sex hormones act as a trigger in only a small subset of women with CU. Nevertheless, this should be taken into account to improve patient management.

Cited by 19 publications

References 14 publications

Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

<p>Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications</p>

Cutting Edge: Biomarkers for Chronic Spontaneous Urticaria

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