Chronic urticaria and Helicobacter pylori

Ortiz, Gaspar Gala; Agustín, M. Cuevas; Martínez, Pablo Eiras; Caballer, Belén de la Hoz; Ordonez, Rosario Fernandez; Macías, Miguel Hinojosa; Boixeda, D; Cosmes, Eloy Losada

doi:10.1016/s1081-1206(10)62301-0

Cited by 21 publications

(7 citation statements)

References 6 publications

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“…The association between H. pylori infection and allergic disease has been investigated in many other studies, but confusion has resulted from the strikingly different results obtained [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. The studies have varied with respect to the type of allergy investigated, the study design, and the race and age of the subjects.…”

Section: Discussionmentioning

confidence: 99%

“…H. pylori mediates an inflammatory response with a chronic persistent infection not only inside the stomach, but also causing extraintestinal diseases that require eradication [1]. Previous studies have shown that H. pylori infection is related to allergic diseases [2][3][4][5], with the presumed pathogenesis that H. pylori infection can provoke histamine release from basophils [6,7]. Conversely, an inverse association between H. pylori infection and allergic diseases has also been reported [8][9][10][11][12][13].…”

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confidence: 99%

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Correlation Between Helicobacter pylori Infection, IgE Hypersensitivity, and Allergic Disease in Korean Adults

Lee

Kim

et al. 2014

Helicobacter

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Correlation Between Helicobacter pylori Infection, IgE Hypersensitivity, and Allergic Disease in Korean Adults

Lee

Kim

et al. 2014

Helicobacter

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“…Most observations (14,15) suggest that H. pylori represents a link between autoimmunity in idiopathic urticaria and chronic infection because of possible development of pathogenic autoantibodies by molecular mimicry, perhaps against lipopolysaccharide in H. pylori. Our findings seem to disagree with these data, as ASST-negative subjects showed anti-H. pylori IgG antibodies (p~0.06) more often than ASST-positive subjects.…”

Section: Discussionmentioning

confidence: 99%

Chronic Idiopathic and Chronic Autoimmune Urticaria: Clinical and Immunopathological Features of 68 Subjects

Caproni¹,

Volpi²,

Giomi³

et al. 2004

Acta Dermato-Venereologica

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Skin tests with autologous serum elicit an immediate wheal-and-flare response in about 30-50% of chronic idiopathic urticaria subjects, suggesting that an autoimmune mechanism might be involved in the pathogenesis of this disease. The aim of the present work, involving 68 subjects with chronic idiopathic urticaria, was to distinguish between the serum-positive and serum-negative cases and highlight the clinical differences between the two groups on the basis of the Breneman scale score. We also tried to correlate the finding of a positive response to the autologous serum skin test with other autoimmune diatheses or fully developed autoimmune disorders. Our results did not demonstrate any significant differences between the two groups with regard to mean age, sex distribution, angioedema and mucosal/cutaneous atopy. However, all subjects with positive autologous serum skin test presented more severe clinical features than serum-negative subjects. We found no differences between the two groups in the incidence of autoimmune disease.

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“…Though this disease cannot be considered a typical autoimmune disease, it is of interest to discuss the findings provided so far, as these may help us understand the role of this pathogen in the development of immune-mediated pathologies. Investigations have not been limited to the prevalence of infection [66] , but have been extended to include the role of eradication therapy in the clinical course of chronic urticaria [77][78][79][80][81][82][83][84][85][86] . Selected papers give us an insight into the extent by which the pathogen and its eradication influence the clinical outcome of the disease.…”

Section: Chronic Urticariamentioning

confidence: 99%

Helicobacter pyloriand autoimmune disease: Cause or bystander

Smyk¹,

Κουτσουμπασ²,

Mytilinaiou³

et al. 2014

WJG

148

108

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Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for gastric cancer. This pathogen has also been considered a potential trigger of gastric autoimmunity, and in particular of autoimmune gastritis. However, a considerable number of reports have attempted to link H. pylori infection with the development of extra-gastrointestinal autoimmune disorders, affecting organs not immediately relevant to the stomach. This review discusses the current evidence in support or against the role of H. pylori as a potential trigger of autoimmune rheumatic and skin diseases, as well as organ specific autoimmune diseases. We discuss epidemiological, serological, immunological and experimental evidence associating this pathogen with autoimmune diseases. Although over one hundred autoimmune diseases have been investigated in relation to H. pylori, we discuss a select number of papers with a larger literature base, and include Sjögrens syndrome, rheumatoid arthritis, systemic lupus erythematosus, vasculitides, autoimmune skin conditions, idiopathic thrombocytopenic purpura, autoimmune thyroid disease, multiple sclerosis, neuromyelitis optica and autoimmune liver diseases. Specific mention is given to those studies reporting an association of anti-H. pylori antibodies with the presence of autoimmune disease-specific clinical parameters, as well as those failing to find such associations. We also provide helpful hints for future research.

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Chronic urticaria and Helicobacter pylori

Cited by 21 publications

References 6 publications

Correlation Between Helicobacter pylori Infection, IgE Hypersensitivity, and Allergic Disease in Korean Adults

Correlation Between Helicobacter pylori Infection, IgE Hypersensitivity, and Allergic Disease in Korean Adults

Chronic Idiopathic and Chronic Autoimmune Urticaria: Clinical and Immunopathological Features of 68 Subjects

Helicobacter pyloriand autoimmune disease: Cause or bystander

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