Chronic Urticaria and Dental Infection

Resch, Charles A.; Evans, Richard

doi:10.3949/ccjm.25.3.147

Cited by 13 publications

(4 citation statements)

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“…Associations between chronic urticaria and occult infection (e.g. dental abscess 4 and gastrointestinal candidiasis 5 ) have been proposed but there is little evidence to support them ( Quality of evidence III ). A meta‐analysis of therapeutic trials for Helicobacter pylori found that resolution of chronic urticaria was more likely when antibiotic therapy was successful than when it was not ( Quality of evidence I, Strength of recommendation B ) 6 .…”

Section: Aetiologymentioning

confidence: 99%

Guidelines for evaluation and management of urticaria in adults and children

Grattan¹,

Humphreys²

2007

Br J Dermatol

156

117

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Summary Appropriate management of urticaria depends on the correct evaluation of clinical patterns and causes where these can be identified. Guidance for treatment is presented, based on the strength of evidence available at the time of preparation. As many of the recommendations relate to the off‐licence use of drugs, it is particularly important that clinicians should be familiar with dosing and side‐effects of treatment in the context of managing urticaria.

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Section: Aetiologymentioning

confidence: 99%

Guidelines for evaluation and management of urticaria in adults and children

Grattan¹,

Humphreys²

2007

Br J Dermatol

156

117

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“…Associations between CIU and occult infections (e.g. dental abscess 2 and gastrointestinal candidiasis 3 ) have been proposed but there is little evidence to support them ( Quality of evidence III ). Thyroid autoimmunity in CIU (14%) is more prevalent than in population controls (6%) 4 ( Quality of evidence II.ii ).…”

Section: Associationsmentioning

confidence: 99%

Management and diagnostic guidelines for urticaria and angio-oedema

2001

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“…However, in a retrospective analysis of 100 chronic urticaria patients referred for dental evaluation, the authors found that 76 had dental infection. [ 28 ]…”

Section: Discussionmentioning

confidence: 99%

Chronic Spontaneous Urticaria

Maheshwari

Garg

Chander

et al. 2022

Indian Journal of Dermatology

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Importance: Exact etiopathogenesis of chronic spontaneous urticaria (CSU) remains elusive. Infections, pseudoallergens, autoimmunity, and contact sensitization are various postulated factors. Few studies are available measuring cytokine levels in CSU. Objectives: The aim was to study various etiological factors of CSU and levels of IL-6 and IFN-ϒ in cases and controls, and correlation between various etiologies with the levels of the abovementioned interleukins in the cases. Design: Case-control study performed over 2 years with no follow-up of the participants. Setting: It was a referral-center-based study. Participants: Sixty patients of CSU and equal age and sex-matched healthy controls were recruited on the basis of convenience sampling. Exposures: Biochemical and hematological investigations with hepatitis serology, thyroid function tests, anti-thyroid antibodies, and levels IL-6 and IFN-ϒ were performed in all cases and controls. All cases were subjected to ASST. Cases with all above negative tests were patch-tested with Indian standard series. Urticaria activity score (UAS7) was calculated for all the cases and repeated in patients with positive etiological factor after 3 weeks (improvement after allergen or drug avoidance, treatment of infection). Outcomes: To study the various etiological factors (food, infection, autoimmunity, autoreactivity, and contact sensitization) and the levels of IL-6 and IFN- γ in patients of chronic spontaneous urticaria. Results: Etiology was ascertained in 75% of patients (autoimmunity: 50%, contact sensitization: 21.67%, food and drug allergy: 1.67% each). Mean values of the interleukins and anti-thyroid antibodies were significantly higher in cases versus controls. Levels of IFN-ϒ were significantly elevated in patients with higher UAS7 scores. Conclusion: Antithyroid antibodies, ASST, and patch testing are important tools and should be considered in patients of CSU after a thorough history and history-based workup. Elevated levels of IL-6 and IFN- ϒ in cases suggest that both Th1 and Th2 type of immune responses are implicated in pathogenesis of CSU.

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Chronic Urticaria and Dental Infection

Cited by 13 publications

References 1 publication

Guidelines for evaluation and management of urticaria in adults and children

Guidelines for evaluation and management of urticaria in adults and children

Management and diagnostic guidelines for urticaria and angio-oedema

Chronic Spontaneous Urticaria

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