Chronic Unpredictable Stress-Induced Behavioral and Electrophysiological Alterations and Its Ameliorative Effect by Myricetin Microemulsion

M, Deva Karunya; Prajisha, Prabhakaran; Cs, Keerthipriya; Rajan, Ramesh

doi:10.22159/ajpcr.2018.v11i3.23364

Cited by 2 publications

References 37 publications

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Psychophysiological stress induced neurobehavioral changes in adolescent rat and their impact in Adult rat enhanced by cinnamaldehyde

Rajan

SEKAR

2022

Preprint

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Adolescent is a tricky developmental period were the Physical, cognitive and social changes takes place. Adolescent brain undergoes vigorous maturation and more susceptible to stressors, distresses in the brain development leading to more susceptibility for stress related psychophysiological disorders in later life. The present study explores the association of adolescent stress on same period and on adult. Adolescent rats were restraint to induce psychophysiological stress from PND28 to PND42.Cinnamaldehyde (CA) 25 mg/kg body weight is treated along with the stress. Restraint stress showed more deleterious effect on learning, memory, anxiety, depression and locomotor activity. The result of this study reveal that adolescent stress has impact on that period and even long-lasting impact. But CA may act as antistressor and cognitive enhancer.

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Psychophysiological stress induced neurobehavioral changes in adolescent rat and their impact in Adult rat enhanced by cinnamaldehyde

Rajan

SEKAR

2022

Preprint

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Imbalance in Sirt1 Alternative Splicing in Response to Chronic Stress during the Adolescence Period in Female Mice

Shlomi

Toledano

Nitzan

et al. 2022

IJMS

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Stressful unpredictable life events have been implicated in numerous diseases. It is now becoming clear that some life periods are more vulnerable than others. As adolescence is a sensitive period in brain development, the long-term effects of stress during this period could be significant. We investigated the long-term effects of exposure to unpredictable chronic mild stress in adolescent mice on alternative splicing of Sirtuin 1. One-month-old mice were exposed to 4 weeks of UCMS and examined for anxiety and cognition at the age of 2, 4 and 6 months. We found a rise in anxious behavior immediately after the exposure to stress. Notably, there was a long-term impairment of performance in cognitive tasks and an imbalance in Sirtuin 1 and TrkB receptor alternative splicing in the stress-exposed mice compared with controls. To conclude, our results show that exposure to unpredictable chronic mild stress during adolescence affects cognition in adulthood. Understanding pathways affiliated with stress may help minimize the long-term emotional effects of an unpredictable, stressful event.

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Chronic Unpredictable Stress-Induced Behavioral and Electrophysiological Alterations and Its Ameliorative Effect by Myricetin Microemulsion

Cited by 2 publications

References 37 publications

Psychophysiological stress induced neurobehavioral changes in adolescent rat and their impact in Adult rat enhanced by cinnamaldehyde

Psychophysiological stress induced neurobehavioral changes in adolescent rat and their impact in Adult rat enhanced by cinnamaldehyde

Imbalance in Sirt1 Alternative Splicing in Response to Chronic Stress during the Adolescence Period in Female Mice

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