Chronic unpredictable mild stress decreases BDNF and NGF levels and Na+,K+-ATPase activity in the hippocampus and prefrontal cortex of mice: Antidepressant effect of chrysin

Filho, Carlos Borges; Jessé, Cristiano Ricardo; Donato, Franciele; Giacomeli, Renata; Fabbro, Lucian Del; Antunes, Michele da Silva; Gomes, Marcelo Gomes de; Goes, André Tiago Rossito; Boeira, Silvana Peterini; Prigol, Marina; Souza, Leandro Cattelan

doi:10.1016/j.neuroscience.2014.12.048

Cited by 153 publications

(114 citation statements)

References 69 publications

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“…This suggests that the alteration in BDNF protein level is dependent on the duration of restraint stress. In addition, subchronic treatment with antidepressants, including fluoxetine and reboxetin, reversed the decrease of BDNF protein induced by chronic stress in the rat hippocampus [4,25]. However, the present study has shown that subchronic linalool treatment (daily i.p.…”

Section: Discussioncontrasting

confidence: 76%

“…The hyperactivation of the HPA axis induces depression-like behavior in the FST (forced swimming test), an animal model used for testing depression [3]. Chronic stress results in a decreased BDNF (brain-derived neurotropic factor) protein level in the hippocampus [4]. alternative treatments, has been used to relieve stress and depression for centuries.…”

Section: Introductionmentioning

confidence: 99%

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Subchronic Administration of Linalool Decreases Depressive-Like Behaviour in Restrained Rats

Saiyudthong¹,

Srijittapong²,

Mekseepralard³

2017

JPP

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Abstract:Objectives: The aim of this study was to investigate the effect of linalool in chronically stressed rats on their behaviour as related to depressive disorders and BDNF (brain-derived neurotropic factor) protein in the hippocampus. Methods: Either Tween 80 or linalool (50, 160, 500 mg/kg) was intraperitoneally administered to rats, daily, for two weeks. Some rats were housed in home cages but the others were induced with chronic restrained stress (15 min daily). At the end of the treatment, the rats were assessed for depressive-like behaviour using the forced swimming test. At the end of the behaviour test, the animals were immediately decapitated and the hippocampus of each animal was removed for the measurement of the BDNF protein by ELISA. Result: The immobility time was significantly increased (p < 0.05) but time of climbing was significantly decreased (p < 0.05). The restrained rats treated with linalool, 500 mg/kg, displayed immobility times less than those of their controls (p < 0.05) while these rats showed significantly more climbing than in the control rats (p < 0.05). Linalool showed no effect on the BDNF protein in the hippocampus. Conclusions: linalool decreases behaviour related to depressive disorders but it has no effect on the BDNF protein in chronic restrained stress.

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Section: Discussioncontrasting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Subchronic Administration of Linalool Decreases Depressive-Like Behaviour in Restrained Rats

Saiyudthong¹,

Srijittapong²,

Mekseepralard³

2017

JPP

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“…Decreased BDNF content in the rat hippocampus following chronic stress has been previously reported (Zheng et al 2006). In more recent studies both BDNF mRNA and protein levels were down-regulated in mice hippocampus after exposure to the CUMS (Filho et al, 2015, Ayuob et al 2016). The reduction in hippocampal BDNF expression in chronic stressful conditions was attributed to corticosterone secretion (Zheng et al 2006).…”

Section: The Parotid Glandmentioning

confidence: 63%

Can Ocimum Basilicum (Basil) Relief the Impact of Chronic Unpredictable Mild Stress on the Mice Salivary Glands?

Ayoub

Ali

Wahab

2018

AJTCAM

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Background: Salivary glands are affected in acute and chronic stressful conditions. Ocimum basilicum (OB), basil, possesses anxiolytic and antidepressant like effect so this study aimed to evaluate the effect of the chronic unpredictable mild stress (CUMS) on the structure of salivary glands of mice and the efficacy of OB in relieving this effect. Material and Methods: Forty male mice were distributed equally into four groups; the control, CUMS (exposed to the CUMS for 4 weeks), CUMS+Fluoxetine (treated with Fluoxetine after exposure to CUMS), CUMS+OB (treated with OB after exposure to CUMS). Treatments continued for 2 weeks. Behavioral changes and serum corticosterone level were assessed at the end of the experiment. Submandibular and parotid glands were histopathologically examined and stained with anti-alpha smooth muscle actin (ASMA) and anti-brain derived neurotropic factor (BDNF) antibodies. Results: A depressive behavior was observed in mice exposed to the CUMS. Serum corticosterone level significantly increased in these mice compared to the control (130.9±8.8 versus 21.03±2.1, p<0.001). Structural affection of salivary acinar and myoepithelial cells of stressed mice was evident. BDNF expression in the salivary ductal system significantly (p<0.001) increased in the stressed mice and treatment with FLU or OB significantly increased it more (p=0.03, p=0.04) when compared to the untreated mice. Conclusion: Ocimum basilicum improved chronic stress-induced depressive status and structural changes in the salivary glands. This effect might be mediated through up-regulating salivary BDNF secretion by the glands so it is the time to test OB effectiveness in relieving stress-associated salivary changes on human being.

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“…These studies have shown that high levels of GCs reduce neurogenesis and synaptogenesis at the PFC and hip-Journal of Behavioral and Brain Science pocampus [38]. Thus, chronic stress decreases metabolism and neurotrophic factors in the pyramidal cells of the median CPF: chronic exposure to glucocorticoids attenuates synaptic proteins (PSD95) and synapsin I [33] following a decrease in the production of BDNF at the median PFC and the hippocampus which causes a depressive state [39]. The PN21 hypercaloric diet and the PN55 CMS induce a non-significant increase in the concentration of glucose and total cholesterol.…”

Section: Discussionmentioning

confidence: 99%

Impact of the Association of a High Fructose Diet and Chronic Mild Stress on Metabolic and Affective Disorders in Male Rat

Chahirou¹,

Lamtai²,

Mesfioui³

et al. 2018

JBBS

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An early unbalanced nutritional diet can induce affective disorders in adulthood. As well as stress in adolescence can accentuate these disorders. Both human and rat structural changes have been demonstrated in the hippocampus, likewise, oxidative stress may be involved in these disturbances. The objective of this study is to see the impact of a high-fructose diet (PN21) associated with chronic mild stress (CMS) at the end of adolescence (PN55) on metabolic and affective disorders in rats Wistar. This study was performed on four groups of male rats: control group, CMS for five weeks (PN55), fructose for ten weeks (PN21) and fructose for ten weeks (PN21) associated with CMS for five weeks (PN55). These animals underwent behavioral tests to evaluate their affective states (open field test, Sucrose preference test). After sacrifice, the dosage of glucose, triglycerides and total cholesterol was performed at the prefrontal cortex (CPF) and also at the hippocampus; the dosage of nitric oxide (NO) was performed, too. The bulk of our results show that fructose induces metabolic disturbances; the CMS induces a state of depression-like, while the association potentiated metabolic disturbances, depression-like state and also inducing anxiety. This study has shown that fructose and CMS can disrupt the various functions of the body and their association can potentiate these disturbances.

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Chronic unpredictable mild stress decreases BDNF and NGF levels and Na+,K+-ATPase activity in the hippocampus and prefrontal cortex of mice: Antidepressant effect of chrysin

Cited by 153 publications

References 69 publications

Subchronic Administration of Linalool Decreases Depressive-Like Behaviour in Restrained Rats

Subchronic Administration of Linalool Decreases Depressive-Like Behaviour in Restrained Rats

Can Ocimum Basilicum (Basil) Relief the Impact of Chronic Unpredictable Mild Stress on the Mice Salivary Glands?

Impact of the Association of a High Fructose Diet and Chronic Mild Stress on Metabolic and Affective Disorders in Male Rat

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