Chronic ulcerative stomatitis associated with a specific immunologic marker

Chronic Ulcerative Stomatitis: A Case Report

“…13 This unique pattern of antinuclear antibody (ANA) has been referred to as stratified epitheliumspecific antinuclear antibody (SES-ANA). 11 It is not, however, known whether this DIF pattern is present only in this disease since similar features have been described by some in the presence of lichenoid drug reactions or lupus erythematosus (LE). 1,7 Autoimmune diseases such as systemic lupus erythematosus (LE), Sjögren's syndrome, scleroderma, and rheumatoid arthritis have been associated with circulating serum antinuclear antibodies and the presence of specific subsets of serum ANA may be diagnostic for those diseases.…”

“…7 Recently, a distinct new disease entity, chronic ulcerative stomatitis (CUS), has been described in a limited number of case reports. [8][9][10][11][12][13] CUS resembles erosive lichen planus or oral discoid lupus erythematosus in its clinical and histologic manifestations. Therefore, it is best diagnosed via immunofluorescence in conjunction with routine histopathology.…”

The diagnostic challenges of separating chronic ulcerative stomatitis from oral lichen planus

“…CUS was identified fairly recently and was first described as a separate entity by Jaremko in 1990. 1 It is an immunopathologic condition in which autoantibodies bind to nuclear protein in stratified squamous epithelium, disrupting epithelial growth and differentiation and resulting in ulcerative lesions or desquamative gingivitis. It is predominantly found in white females over the age of 50 years.…”

Desquamative gingivitis: A sign of mucocutaneous disorders‐a review

“…12,59 Chronic ulcerative stomatitis This is a new entity characterized by unique immunostaining properties. 60 It mimics oral lichen planus both clinically and histologically. Desquamative gingivitis can be its presenting feature as well.…”