Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats

Sharma, Monisha; Gupta, Yamini

doi:10.1016/s0024-3205(02)02083-0

Cited by 285 publications

(144 citation statements)

References 23 publications

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“…Many of antioxidant drugs have also been tested in the STZ-icv animal sAD models, suitable for such task due to the chemical nature of STZ which leads to generation of intracellular free radicals, nitric oxide (NO) and hydrogen peroxide, and mitochondrial damage (Szkudelski 2001). In line with that, significant and progressive elevation of MDA and decrement of GSH level, respectively, as well as oxidative-nitrative stress have been found in the rat brain 1 to 8 weeks following the STZ-icv treatment (Sharma and Gupta 2001a;Sharma and Gupta 2002;Ishrat et al 2006;Pathan et al 2006;Shoham et al 2007;Kumar et al 2010;Saxena et al 2011), demonstrating resemblance to the oxidative stress condition in the human sAD patients post-mortem.…”

Section: Compounds With Predominant Antioxidative Activity Often Accsupporting

confidence: 68%

“…Anti-amyloidogenic potential of resveratrol has not been explored in the STZ-icv rat sAD model but chronic treatment with trans resveratrol (10 and 20 mg/kg, i.p. for 21 days) starting from day 1 of STZ-icv injection significantly prevented STZ-icv induced cognitive impairment and oxidative stress manifested as increased brain GSH levels (Sharma and Gupta 2002).…”

Section: Compounds With Predominant Antioxidative Activity Often Accmentioning

confidence: 89%

“…Following the parenteral administration of high doses, STZ selectively destroys insulin producing/secreting β cells in the pancreas, causing DM type I in adult animals (Szkudelski 2001), while multiple parenteral treatment with low to moderate STZ doses causes insulin resistance by damaging insulin receptor (IR) signalling (Blondel and Portha 1989;Kadowaki et al 1984;Giorgino et al 1992). Intracerebroventricular administration of low, subdiabetogenic doses of STZ has been shown to induce cognitive (Mayer et al 1991;Lannert and Hoyer 1998) and brain cholinergic deficits (Hellweg et al 1992;Blockland andJolles 1993, 1994), oxidative stress (Sharma and Gupta, 2001a;Sharma and Gupta 2002;Ishrat et al 2006;Pathan et al 2006;Shoham et al, 2006;Kumar et al, 2010;Saxena et al, 2011) as well as decrement in brain glucose/energy metabolism (Nitsch and Hoyer 1991;Plaschke et al 1996;Lannert and Hoyer 1998;Hoyer and Lannert 2007), and insulin resistant brain state (Salkovic-Petrisic et al 2006;Gruenblatt et al 2007;Steen 2006;Lester-Coll et al 2006;Agrawal et al 2010). These STZ-icv induced effects have been extensively reviewed elsewhere Salkovic-Petrisic et al 2012), and will not be elaborated here.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

et al. 2012

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Section: Compounds With Predominant Antioxidative Activity Often Accsupporting

confidence: 68%

Section: Compounds With Predominant Antioxidative Activity Often Accmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

et al. 2012

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“…The mice received resveratrol for only four weeks before testing began, while in previous studies, where resveratrol was shown to improve cognitive functions, the subjects were given resveratrol for at least onethird of their lifespan [13,49]. Short periods of resveratrol treatment in rats have been shown to produce positive effects on cognition, but the animals used in those studies had been subjected to neurological trauma or treatment with a neurotoxic substance [50,51]. The failure to observe an effect after short-term treatment is a logical outcome if resveratrol's effect on cognitive function is mediated through Advances in Neuroscience 5 protecting the brain against damage [44].…”

Section: Discussionmentioning

confidence: 99%

Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

Muhammad

Magaji

Mohammed

et al. 2014

Advances in Neuroscience

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Caloric restriction and environmental enrichment have been separately reported to possess health benefits such as improvement in motor and cognitive functions. Resveratrol, a natural polyphenolic compound, has been reported to be caloric restriction mimetic. This study therefore aims to investigate the potential benefit of the combination of resveratrol as CR and EE on learning and memory, motor coordination, and motor endurance in young healthy mice. Fifty mice of both sexes were randomly divided into five groups of 10 animals each: group I animals received carboxymethylcellulose (CMC) orally per kg/day (control), group II animals were maintained on every other day feeding, group III animals received resveratrol 50 mg/kg, suspended in 10 g/L of (CMC) orally per kg/day, group IV animals received CMC and were kept in an enriched environment, and group V animals received resveratrol 50 mg/kg and were kept in EE. The treatment lasted for four weeks. On days 26, 27, and 28 of the study period, the animals were subjected to neurobehavioural evaluation. The results obtained showed that there was no significant change ( > 0.05) in neurobehavioural responses in all the groups when compared to the control which indicates that 50 mg/kg of resveratrol administration and EE have no significant effects on neurobehavioural responses in young healthy mice over a period of four weeks.

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“…The head was positioned in a stereotaxic frame and a midline sagittal incision was made in the scalp. Burr holes were drilled in the skull on both sides over the lateral ventricles by using the following coordinates: 0.8 mm posterior to bregma; 1.5 mm lateral to sagittal suture and 3.5 mm beneath the surface of the brain (Sharma and Gupta 2002). Coordinates for placement of cannulae were determined by using the atlas of Paxinos and Watson (1998).…”

Section: Intracerebroventricular Injection Of Streptozotocinmentioning

confidence: 99%

Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model

Işık

Çelik

Ulusoy

et al. 2008

AGE

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Increased serum insulin levels and reduced peripheral insulin activities seen in insulin resistance syndrome are associated with age-dependent cognitive impairment and Sporadic Alzheimer's Disease (SAD), suggesting a disturbance in the insulin signalling system in the brain and possibly being one of the causes of dementia. Therefore, the streptozotocin (STZ)-induced animal may be an appropriate model for the investigation of SAD and related dementia. This study was designed to investigate the beneficial effect of Curcumin (CUR), a neuroprotective agent, on intracerebroventricular (ICV) STZ-induced cognitive impairment in rats. For this purpose, adult male Wistar rats were bilaterally ICV injected with STZ (3 mg/kg). An artificial cerebrospinal fluid (aCSF) was given to the control group (SHAM) instead of STZ on days 1 and 3. Learning and memory performance were assessed using the "passive avoidance task" and the "Morris water maze test". After confirmation of acquisition impairment with these tests, the STZ group was divided into two subgroups: STZ+ vehicle (Vh) and STZ+CUR. The rats in the SHAM and STZ+Vh groups were administered intraperitoneally with 0.5 ml Vh and the rats in the STZ+CUR group were treated intraperitoneally with CUR (300 mg kg −1 day −1 in Vh) for 10 days starting from the 25th day after STZ injection. The Morris water maze test was reapplied on the 35th day after STZ injection and all of the rats were sacrificed on day 36 for quantitation of IGF-1 and for histopathological evaluation. Rats in the STZ+CUR group were found to have a higher performance in cognitive tests than rats in the STZ+Vh group (P<0.01). In parallel with the cognitive tests, IGF-1 levels were decreased in all of the STZ-injected groups (1.78±0.34) compared to the SHAM group (3.46±0.41). In contrast, CUR treatment significantly increased IGF-1 levels (P<0.001). The degree of neuronal loss decreased after CUR treatment compared to the SHAM group (P< 0.02). These results clearly indicate that CUR treatment is effective in reducing the cognitive impairment caused AGE

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Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats

Cited by 285 publications

References 23 publications

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model

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