Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice

Ho, Ming Che; Cherng, Chianfang G.; Tsai, Yen Ping N.; Chiang, Chih Yuan; Chuang, Jia Ying; Kao, Shu Fang; Yu, Lung

doi:10.1007/s00213-009-1524-5

Cited by 16 publications

(12 citation statements)

References 25 publications

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“…Approximately 20 h after the 6th injection of rimonabant, the locomotor activity was monitored for 15 min as previously described (Ho et al 2009;Lin et al 2011). …”

Section: Methodsmentioning

confidence: 99%

Medial prefrontal cannabinoid CB1 receptors modulate consolidation and extinction of cocaine-associated memory in mice

Liu

2014

Psychopharmacology

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“…Approximately 20 h after the 6th injection of rimonabant, the locomotor activity was monitored for 15 min as previously described (Ho et al 2009;Lin et al 2011). …”

Section: Methodsmentioning

confidence: 99%

Medial prefrontal cannabinoid CB1 receptors modulate consolidation and extinction of cocaine-associated memory in mice

Liu

2014

Psychopharmacology

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“…The MAOB is a DA degrading enzyme and is possibly involved in behavioral effects of cocaine. In fact, chronic pre-treatment with a MAOB inhibitor prevents the establishment of cocaine self-administration [115]. Further, the MAOB inhibitor suppresses the prolonged behavioral sensitization induced by cocaine during cocaine-withdrawal [113].…”

Section: Sig-1r-related Molecular Mechanisms and The Actions Of Cocaimentioning

confidence: 99%

Potential Molecular Mechanisms on the Role of the Sigma-1 Receptor in the Action of Cocaine and Methamphetamine

Yasui

2016

J Drug Alcohol Res

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The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum membrane protein that involves a wide range of physiological functions. The Sig-1R has been shown to bind psychostimulants including cocaine and methamphetamine (METH) and thus has been implicated in the actions of those psychostimulants. For example, it has been demonstrated that the Sig-1R antagonists mitigate certain behavioral and cellular effects of psychostimulants including hyperactivity and neurotoxicity. Thus, the Sig-1R has become a potential therapeutic target of medication development against drug abuse that differs from traditional monoamine-related strategies. In this review, we will focus on the molecular mechanisms of the Sig-1R and discuss in such a manner with a hope to further understand or unveil unexplored relations between the Sig-1R and the actions of cocaine and METH, particularly in the context of cellular biological relevance.

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“…Throughout the experiment, mice had access to water ad libitum. However, these mice were under food deprivation and their body weights were monitored as previously reported [28] . Bilateral cannula implantation was done a week before the beginning of the pretest.…”

Section: Food-induced Cpp Training and Testmentioning

confidence: 99%

“…They all received 5-day food-induced CPP trainings. Each morning, mice were confined in the non-preferred compartment where 4 sucrose pellets [28] were provided in a tray for 15 min. Eight hours apart, mice were placed in the preferred compartment where an empty tray was available for 15 min.…”

Section: Food-induced Cpp Training and Testmentioning

confidence: 99%

“…These results suggest that decreased CPP magnitude in procedure 1 or 2 was not due to the motor activity-impairing effect produced by accumbal 14-3-3 protein expression. Since 14-3-3 protein was documented to modulate tyrosine hydroxylase activity and DA synthesis in MN9D cells [28] , accumbal DA and its primary metabolite, DOPAC, were assessed for the potential effect of 14-3-3 plasmid DNA infusion on DA metabolism in mouse NAc. Three groups of mice (14-3-3 plasmid DNA-infused group, n = 5; vector-infused group, n = 8; naïve control group, n = 8) were used.…”

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Accumbal 14-3-3ζ Protein Downregulation Is Associated with Cocaine-Conditioned Memory

et al. 2011

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Cocaine-conditioned memory has been known to cause cocaine craving and relapse, while its underlying mechanisms remain unclear. We explored accumbal protein candidates responsible for a cocaine-conditioned memory, cocaine-induced conditioned place preference (CPP). Two-dimensional gel electrophoresis in conjunction with liquid chromatography mass spectrometry analysis was utilized to identify accumbal protein candidates involved in the retrieval of cocaine-induced CPP. Among the identified candidate proteins, a downregulated 14-3-3ζ protein was chosen and confirmed by Western immunoblotting. A polymer-mediated plasmid DNA delivery system was then used to overexpress 14-3-3 protein in mouse nucleus accumbens before the CPP retrieval tests. Overexpression of accumbal 14-3-3ζ protein was found to diminish conditioned cue/context-mediated cocaine-induced CPP. In contrast, another isoform of 14-3-3 protein, 14-3-3ε protein, did not affect conditioned cue/context-mediated cocaine-induced CPP. Overexpression of accumbal 14-3-3ζ protein did not produce motor activity-impairing effect or alter local dopamine metabolism. Moreover, overexpression of accumbal 14-3-3ζ protein did not affect food-induced CPP. These results, taken together, indicated that overexpressed accumbal 14-3-3ζ protein specifically decreased conditioned cue/context-mediated cocaine memory. Further understanding of the function of accumbal 14-3-3ζ protein may shed light on the treatment of cocaine craving and relapse.

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Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice

Abstract: We suggest that long-term treatments with MAO-B inhibitors may decrease cocaine-supported operant responses in cocaine-naïve mice by selectively decreasing frontal cortical metabolism of dopamine and serotonin.

Cited by 16 publications

References 25 publications

Medial prefrontal cannabinoid CB1 receptors modulate consolidation and extinction of cocaine-associated memory in mice

Medial prefrontal cannabinoid CB1 receptors modulate consolidation and extinction of cocaine-associated memory in mice

Potential Molecular Mechanisms on the Role of the Sigma-1 Receptor in the Action of Cocaine and Methamphetamine

Accumbal 14-3-3ζ Protein Downregulation Is Associated with Cocaine-Conditioned Memory

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