Chronic treatment with caffeine blunts the hyperlocomotor but not cognitive effects of the N-methyl-d-aspartate receptor antagonist MK-801 in mice

Dall'Igna, Oscar Phelippe Permigotti; Silva, Adriana L. da; Dietrich, Marcelo O.; Hoffmann, Ana; Oliveira, Ricardo Vígolo de; Souza, Diogo O.; Lara, Diogo R.

doi:10.1007/s00213-002-1362-1

Cited by 38 publications

(26 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Both doses of MK-801 (0.05 and 0.10 mg/ kg) produced the expected impairments in spatial reversal learning and in contextual and cued memory. In addition, MK-801 produced hyperlocomotion, as has been observed in previous studies (Bardgett et al, 2003;Dall'Igna et al, 2003). Physostigmine and donepezil were both effective in ameliorating the deficits in spatial reversal learning and in contextual and cued memory produced by MK-801 administration in a dose-dependent manner.…”

Section: Discussionsupporting

confidence: 84%

Cholinesterase Inhibitors Ameliorate Behavioral Deficits Induced by MK-801 in Mice

Csernansky

Martin

Shah

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

Enhancing cholinergic function has been suggested as a possible strategy for ameliorating the cognitive deficits of schizophrenia. The purpose of this study was to examine the effects of acetylcholinesterase (AChE) inhibitors in mice treated with the noncompetitive Nmethyl-d-aspartate (NMDA) receptor antagonist, MK-801, which has been suggested as an animal model of the cognitive deficits of schizophrenia. Three separate experiments were conducted to test the effects of physostigmine, donepezil, or galantamine on deficits in learning and memory induced by MK-801. In each experiment, MK-801 (0.05 or 0.10 mg/kg) or saline was administered i.p. 20 min prior to behavioral testing over a total of 12 days. At 30 min prior to administration of MK-801 or saline, one of three doses of the AChE inhibitor (ie physostigmineF0.03, 0.10, or 0.30 mg/kg; donepezilF0.10, 0.30, or 1.00 mg/kg; or galantamineF0.25, 0.50, or 1.00 mg/kg) or saline was administered s.c. Behavioral testing was performed in all experimental animals using the following sequence: (1) spatial reversal learning, (2) locomotion, (3) fear conditioning, and (4) shock sensitivity. Both doses of MK-801 produced impairments in spatial reversal learning and in contextual and cued memory, as well as hyperlocomotion. Physostigmine and donepezil, but not galantamine, ameliorated MK-801-induced deficits in spatial reversal learning and in contextual and cued memory in a dose-dependent manner. Also, physostigmine, but not donepezil or galantamine, reversed MK-801-induced hyperlocomotion. Galantamine, but not physostigmine or donepezil, altered shock sensitivity. These results suggest that AChE inhibitors may differ in their capacity to ameliorate learning and memory deficits produced by MK-801 in mice, which may have relevance for the cognitive effects of cholinomimetic drugs in patients with schizophrenia.

show abstract

Section: Discussionsupporting

confidence: 84%

Cholinesterase Inhibitors Ameliorate Behavioral Deficits Induced by MK-801 in Mice

Csernansky

Martin

Shah

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Actually, this distinct effect of toluene on NMDA antagonists-produced behavioral responses is not unique. Chronic treatment with caffeine blunts the hyperlocomotor, but not cognitive effects of the MK-801 (Dall'Igna et al 2003). On the other hand, estrogen treatment can alleviate NMDA receptor antagonist-induced cognitive deficits, while leaving NMDA antagonist-induced locomotor activity and incoordination unaffected in ovariectomized mice (Gureviciene et al 2003).…”

Section: Discussionmentioning

confidence: 97%

Toluene exposure during the brain growth spurt reduces behavioral responses to noncompetitive N-methyl-d-aspartate receptor antagonists in adult rats

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Ozyurt et al (2007) reported that ADA activity was significantly increased in the prefrontal cortex of rats in an MK-801-induced experimental psychosis model. Interestingly, chronic treatment with the adenosine receptor antagonist caffeine, which induces adaptive changes to a low endogenous adenosine signal, significantly reduced the hyperlocomotor and amnesic effects of MK-801 in mice (Dall'Igna et al 2003;de Oliveira et al 2005). ADA activity is involved in the regulation of adenosine levels in the extracellular milieu and also interacts with A 1 receptors (Franco et al 1997).…”

Section: Discussionmentioning

confidence: 97%

Investigation into effects of antipsychotics on ectonucleotidase and adenosine deaminase in zebrafish brain

Seibt

Oliveira

Bogo

et al. 2015

Fish Physiol Biochem

View full text Add to dashboard Cite

Antipsychotic agents are used for the treatment of psychotic symptoms in patients with several brain disorders, such as schizophrenia. Atypical and typical antipsychotics differ regarding their clinical and side-effects profile. Haloperidol is a representative typical antipsychotic drug and has potent dopamine receptor antagonistic functions; however, atypical antipsychotics have been developed and characterized an important advance in the treatment of schizophrenia and other psychotic disorders. Purine nucleotides and nucleosides, such as ATP and adenosine, constitute a ubiquitous class of extracellular signaling molecules crucial for normal functioning of the nervous system. Indirect findings suggest that changes in the purinergic system, more specifically in adenosinergic activity, could be involved in the pathophysiology of schizophrenia. We investigated the effects of typical and atypical antipsychotics on ectonucleotidase and adenosine deaminase (ADA) activities, followed by an analysis of gene expression patterns in zebrafish brain. Haloperidol treatment (9 µM) was able to decrease ATP hydrolysis (35%), whereas there were no changes in hydrolysis of ADP and AMP in brain membranes after antipsychotic exposure. Adenosine deamination in membrane fractions was inhibited (38%) after haloperidol treatment when compared to the control; however, no changes were observed in ADA soluble fractions after haloperidol exposure. Sulpiride (250 µM) and olanzapine (100 µM) did not alter ectonucleotidase and ADA activities. Haloperidol also led to a decrease in entpd2_mq, entpd3 and adal mRNA transcripts. These findings demonstrate that haloperidol is an inhibitor of NTPDase and ADA activities in zebrafish brain, suggesting that purinergic signaling may also be a target of pharmacological effects promoted by this drug.

show abstract

Chronic treatment with caffeine blunts the hyperlocomotor but not cognitive effects of the N-methyl-d-aspartate receptor antagonist MK-801 in mice

Cited by 38 publications

References 38 publications

Cholinesterase Inhibitors Ameliorate Behavioral Deficits Induced by MK-801 in Mice

Cholinesterase Inhibitors Ameliorate Behavioral Deficits Induced by MK-801 in Mice

Toluene exposure during the brain growth spurt reduces behavioral responses to noncompetitive N-methyl-d-aspartate receptor antagonists in adult rats

Investigation into effects of antipsychotics on ectonucleotidase and adenosine deaminase in zebrafish brain

Contact Info

Product

Resources

About