Chronic Traumatic Encephalopathy: Connecting Mechanisms to Diagnosis and Treatment

Milani, Christina; Jadavji, Nafisa M.

doi:10.22186/jyi.33.4.83-86

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Magnetic resonance imaging (MRI) can detect cerebral atrophy, axonal injury, dilated perivascular spaces, ventricular enlargement, and cavum septum pellucidum [6,[48][49][50][51][52]. MRI with FLAIR can be used to assess white matter hyperintensities and can represent a variety of neuropathology [53]. Diffuse Tensor Imaging (DTI) is another way of assessing white matter and has become a popular potential imaging modality to assist in the diagnosis of CTE.…”

Section: Diagnosticsmentioning

confidence: 99%

“…However, studies using larger sample sizes will be needed to validate these promising results [52,56,57]. Other probes which could be helpful include tracers for beta-amyloid, TDP-43, 18-FG D, and markers of neuroinflammation [49,52,53,57,58]. In addition to imaging modalities, serum and CSF biomarkers could help identify CTE as well as possible risk factors and prognostic information [6,52,59,60].…”

Section: Diagnosticsmentioning

confidence: 99%

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Management of Neuropsychiatric Symptoms for Chronic Traumatic Encephalopathy

Fusco¹,

Olowofela²,

Dagra³

et al. 2022

MPPBS

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Section: Diagnosticsmentioning

confidence: 99%

Section: Diagnosticsmentioning

confidence: 99%

Management of Neuropsychiatric Symptoms for Chronic Traumatic Encephalopathy

Fusco¹,

Olowofela²,

Dagra³

et al. 2022

MPPBS

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“…Use of diffusion tensor imaging (DTI) to assess white matter integrity has become a popular tool for assisting in the diagnosis of CTE [26]. Research indicates it may be useful in determining the relationship between cognitive deficits and TBI and in distinguishing the spectrum of brain injury, even when the injury was sustained years prior [27].…”

Section: Diagnostic Imagingmentioning

confidence: 99%

Chronic Traumatic Encephalopathy: Update on Current Clinical Diagnosis and Management

et al. 2021

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Chronic traumatic encephalopathy is a disease afflicting individuals exposed to repetitive neurotrauma. Unfortunately, diagnosis is made by postmortem pathologic analysis, and treatment options are primarily symptomatic. In this clinical update, we review clinical and pathologic diagnostic criteria and recommended symptomatic treatments. We also review animal models and recent discoveries from pre-clinical studies. Furthermore, we highlight the recent advances in diagnosis using diffusor tensor imaging, functional magnetic resonance imaging, positron emission tomography, and the fluid biomarkers t-tau, sTREM2, CCL11, NFL, and GFAP. We also provide an update on emerging pharmaceutical treatments, including immunotherapies and those that target tau acetylation, tau phosphorylation, and inflammation. Lastly, we highlight the current literature gaps and guide future directions to further improve clinical diagnosis and management of patients suffering from this condition.

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