Chronic Toxoplasma gondii infection contributes to decreasing of perineuronal nets surrounding neurons in the Corpus striatum of mice

Brito, Ramayana Morais de Medeiros; Meurer, Ywlliane da Silva Rodrigues; Santos, Lidiane da Silva; Marcelino, Brenna Marceliane de Melo; Andrade‐Neto, Valter Ferreira de

doi:10.1007/s00436-020-06674-8

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…All the data presented here highlight the ability of T. gondii to interfere in the cerebral structure, which might be involved in the assembly of abnormal behavior as shown in our previous work, in which T. gondii -infected mice exhibited reduced PNNs surrounding neurons and displayed a hyperlocomor profile [ 11 , 31 ]. In this context, and considering the differences in the inflammatory level among susceptible and resistant infected mice, it is plausible to establish a relationship between the immunological response triggered and modulated by T. gondii with the impairment of structural components of the CNS of susceptible C57BL/6 and resistant BALB/c mice.…”

Section: Discussionsupporting

confidence: 65%

Chronic Toxoplasma gondii infection contributes to perineuronal nets impairment in the primary somatosensory cortex

et al. 2022

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Toxoplasma gondii is able to manipulate the host immune system to establish a persistent and efficient infection, contributing to the development of brain abnormalities with behavioral repercussions. In this context, this work aimed to evaluate the effects of T. gondii infection on the systemic inflammatory response and structure of the primary somatosensory cortex (PSC). C57BL/6 and BALB/c mice were infected with T. gondii ME49 strain tissue cysts and accompanied for 30 days. After this period, levels of cytokines IFN-γ, IL-12, TNF-α and TGF-β were measured. After blood collection, mice were perfused and the brains were submitted to immunohistochemistry for perineuronal net (PNN) evaluation and cyst quantification. The results showed that C57BL/6 mice presented higher levels of TNF-α and IL-12, while the levels of TGF-β were similar between the two mouse lineages, associated with the elevated number of tissue cysts, with a higher occurrence of cysts in the posterior area of the PSC when compared to BALB/c mice, which presented a more homogeneous cyst distribution. Immunohistochemistry analysis revealed a greater loss of PNN labeling in C57BL/6 animals compared to BALB/c. These data raised a discussion about the ability of T. gondii to stimulate a systemic inflammatory response capable of indirectly interfering in the brain structure and function. Graphical Abstract

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Section: Discussionsupporting

confidence: 65%

Chronic Toxoplasma gondii infection contributes to perineuronal nets impairment in the primary somatosensory cortex

et al. 2022

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“…It has been reported that the primary neurosphere produced by cerebrum nerve stem/progenitor cells are mainly differentiated into astrocytes and oligodendrocytes. Hoxb3 is the main transcription factor regulating the differentiation of oligodendrocytes, which are the myelinating cells of the central nervous system (CNS; De Medeiros Brito et al, 2020 ). This study first demonstrated that Hoxb3 regulated functional changes in microglia.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of lncRNA147410.3 in the Brain of Mice With Chronic Toxoplasma Infection Promoted Microglia Apoptosis by Regulating Hoxb3

Wang

Han

et al. 2021

Front. Cell. Neurosci.

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Toxoplasma gondii is neurotropic and affects the function of nerve cells, while the mechanism is unclear. LncRNAs are abundantly enriched in the brain and participated in the delicate regulation of the central nervous system (CNS) development. However, whether these lncRNAs are involved in the regulation of microglia activation during the process of T. gondii infection is largely unknown. In this study, the upregulation of a novel lncRNA147410.3 (ENSMUST00000147410.3) was identified as a key factor to influence this process. The target gene of lncRNA147410.3 was predicted and identified as Hoxb3. The localization of lncRNA147410.3 in the brain and cells was proved in the nucleus of neuroglia through FISH assay. Furthermore, the function of lncRNA147410.3 on neuronal cell was confirmed that lncRNA147410.3 could affect proliferation, differentiation, and apoptosis of mouse microglia by positively regulating Hoxb3. Thus, our study explored the modulatory action of lncRNA147410.3 in T. gondii infected mouse brain, providing a scientific basis for using lncRNA147410.3 as a therapeutic target to treat neurological disorder induced by T. gondii.

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“…In experimental murine models for T. gondii chronic infection, tissue cysts are formed mainly within neurons, which persist throughout the life of the host ( Cabral et al, 2016 ). Chronic infection contributes to the establishment of a constant neuroinflammation, impairing the central nervous system (CNS) homeostasis and functioning, by triggering altered synaptic signals, dysregulation of neurotransmitters, and impairment of perineuronal nets ( Torres et al, 2018 ; Brito et al, 2020 ; Meurer et al, 2020 ). The distinct inflammatory patterns and host cerebral modifications in response to the parasite's presence can be explained by the high genetic variability among the T. gondii strains ( Robben et al, 2004 ; Khan et al, 2009 ; Zhang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Chronic infection by atypical Toxoplasma gondii strain induces disturbance in microglia population and altered behaviour in mice

Brito,

da Silva,

Vieira-Santos

et al. 2023

Brain, Behavior, & Immunity - Health

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Chronic Toxoplasma gondii infection contributes to decreasing of perineuronal nets surrounding neurons in the Corpus striatum of mice

Cited by 4 publications

References 33 publications

Chronic Toxoplasma gondii infection contributes to perineuronal nets impairment in the primary somatosensory cortex

Chronic Toxoplasma gondii infection contributes to perineuronal nets impairment in the primary somatosensory cortex

Upregulation of lncRNA147410.3 in the Brain of Mice With Chronic Toxoplasma Infection Promoted Microglia Apoptosis by Regulating Hoxb3

Chronic infection by atypical Toxoplasma gondii strain induces disturbance in microglia population and altered behaviour in mice

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