Chronic toxicity of nonylphenol and ethinylestradiol: haematological and histopathological effects in juvenile Common carp (Cyprinus carpio)

Schwaiger, Jens; Spieser, O. Hunrich; Bauer, Christoph; Ferling, Hermann; Mallow, U.; Kalbfus, W.; Negele, R. D.

doi:10.1016/s0166-445x(00)00098-9

Cited by 116 publications

(67 citation statements)

References 28 publications

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“…An estrogen-dependent depression in gluconeogenesis had been demonstrated in rainbow trout (Cevdet et al, 2003). A reduction of hepatic glycogen deposits observed in the present work has also been observed in estrogen-treated carp (Schwaiger et al, 2000) and flounder (Zaroogian et al, 2001). The results showed that endocrine disruptors caused hepatic tissue impairment of rare minnows due to inducing and accumulating VTG.…”

Section: Hepatic Tissuesupporting

confidence: 84%

“…Esinophilic material was most probably VTG (Herman and Kincaid, 1988), synthesized under the stimulation of estrogenic chemicals such as EE 2 , and accumulated in various tissues. The hypertrophy and degenerative and necrotic of the tubular epithelia were observed in estrogen treated carp (Schwaiger et al, 2000) and flounder (Zaroogian et al, 2001). The results showed that renal tissue impairment of rare minnow was caused not only by chronic toxicity of endocrine disruptors but also by VTG accumulation.…”

Section: Renal Tissuementioning

confidence: 87%

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Histological alternation and vitellogenin induction in adult rare minnow (Gobiocypris rarus) after exposure to ethynylestradiol and nonylphenol

Zha¹,

Wang²,

Wang³

et al. 2007

Chemosphere

156

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Adult rare minnow (Gobiocypris rarus) were exposed to 0, 1, 5, and 25 ng/l (nominal concentrations) of 17a-ethynylestradiol (EE 2 ) and 3, 10, and 30 lg/l (nominal concentrations) of 4-nonylphenol (NP) under flow-through conditions for a period of 28 d. Low mortality was observed at 5 and 25 ng/l EE 2 and the growth of fish reduced significantly at 25 ng/l EE 2 compared to controls. However, the gonadosomatic indices (GSI) of male fish were significantly higher in 1 ng/l EE 2 treatments and in 10 and 30 lg/l NP treatments (p < 0.05). Renal somatic indices (RSI) of male fish in EE 2 treatments were significantly higher than those in controls (p < 0.05). In contrast, significantly decreased GSI and RSI of female fish could only be observed in 5 and 25 ng/l EE 2 treatments (p < 0.05). Hepatosomatic indices (HSI) of male fish were significantly higher in 25 ng/l EE 2 treatments. However, significantly increased of HSI of female fish could only be observed in 1 ng/l EE 2 treatments. Plasma vitellogenin (VTG) induction could be observed in males after exposed to different concentrations of EE 2 and NP, and plasma VTG concentrations in females exposed to 5 and 25 ng/l EE 2 were also significantly higher than in controls (p < 0.05). At level higher than 5 ng/l EE 2 or 30 lg/l NP, hepatic tissue and renal tissue impairment of males could be observed. The pathological male liver was associated with a hypertrophy of hepatocytes and damages to cellar structure and accumulated eosinophilic material. Renal tissue showed different pathological effects which was reflected by accumulated eosinophilic material, hemorrhages within the kidney tubules and hypertrophy of the tubular epithelia. Also at these levels of exposure, feminization of male fish could be noticed and parts of males manifested the testis-ova phenomenon. Ovaries of female rare minnow in 25 ng/l EE 2 treatment group were degenerated. Therefore when exposed to EE 2 and NP even at environmental observed concentrations, adverse effects could occur in the reproductive system of adult fishes. The observed hepatic tissue and renal tissue impairment should be due to the induction and accumulation of VTG in organs, especially in males.

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Section: Hepatic Tissuesupporting

confidence: 84%

Section: Renal Tissuementioning

confidence: 87%

Histological alternation and vitellogenin induction in adult rare minnow (Gobiocypris rarus) after exposure to ethynylestradiol and nonylphenol

Zha¹,

Wang²,

Wang³

et al. 2007

Chemosphere

156

View full text Add to dashboard Cite

show abstract

“…In addition, high plasma concentrations of a large protein might cause a blocking of small capillaries, as present in the glomeruli of the kidney and also in the liver. This would explain the histopathological changes of the main excretion (kidney) and metabolizing (liver) organs following the exposure to EDCs described elsewhere (Nicholls et al, 1968;Lewis et al, 1976;Hori et al, 1979;Schweinfurth et al, 1997;Schwaiger et al, 2000), and could also contribute to the observed mortality. The slightly increased mortality in the solvent control (between days 35 and 56) lies within the natural variability.…”

Section: Discussionmentioning

confidence: 75%

Determination of vitellogenin kinetics in male fathead minnows (Pimephales promelas)

et al. 2002

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A lack of knowledge persists concerning the combination of kinetics on protein and mRNA levels of the most commonly used biomarker for estrogenic influences-vitellogenin (VTG). Consequently, male fathead minnows were exposed to 17a-ethinylestradiol (EE 2 ) for 35 days, followed by an equally long depuration period in a flow-through system. VTG mRNA levels reached a plateau after 3 days of exposure, which remained stable until 3 days after EE 2 removal. Control levels were re-attained within 7 days of the depuration phase. VTG protein accumulated in the plasma following a two-phased model. The first phase depicting an exponential increase lasted 15 days and was followed by a saturation phase approaching a plateau of approximately 47 mg VTG/ml plasma. Clearance kinetics could be described by a two-compartment open model, with half-lives of 2.17 and 21.32 days for the a-and b-phases, respectively. In addition, a high VTG protein synthesis rate seemed to adversely affect fitness and mortality of the fish.

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“…At rest, 'all-fish' GH transgenic carp had similar hematocrit and hemoglobin, but lower MCHC, compared to non-transgenic controls, with all values within normal ranges for carp (Schwaiger et al, 2000;Wojtaszek, et al, 2002;Harikrishnan et al, 2003;Walencik and Witeska, 2007). However, Wang et al (2005) found that 'all-fish' GH transgenic carp had higher hematocirts than age-matched siblings, but transgenics were also significantly heavier and body weight has been shown to affect hematocrit (Houston, 1990(Houston, , 1997.…”

Section: Physiological Response To Exhaustive Exercisementioning

confidence: 99%

The hematological response to exhaustive exercise in ‘all-fish’ growth hormone transgenic common carp (Cyprinus carpio L.)

Wang

et al. 2011

Aquaculture

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Chronic toxicity of nonylphenol and ethinylestradiol: haematological and histopathological effects in juvenile Common carp (Cyprinus carpio)

Cited by 116 publications

References 28 publications

Histological alternation and vitellogenin induction in adult rare minnow (Gobiocypris rarus) after exposure to ethynylestradiol and nonylphenol

Histological alternation and vitellogenin induction in adult rare minnow (Gobiocypris rarus) after exposure to ethynylestradiol and nonylphenol

Determination of vitellogenin kinetics in male fathead minnows (Pimephales promelas)

The hematological response to exhaustive exercise in ‘all-fish’ growth hormone transgenic common carp (Cyprinus carpio L.)

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