Chronic toxicity of methylmercury in the adult cat interim report

Charbonneau, S.M.; Munro, I.C.; Nera, E.A.; Armstrong, Fräser A.; Willes, R. F.; Bryce, F.; Nelson, Ralph

doi:10.1016/0300-483x(76)90052-4

Cited by 53 publications

(34 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hg and Se content and the Hg/Se ratios for the processed fish are shown in Table 1. Two basal diets (modified from that used for cats [8]) were prepared. The major ingredients besides fish and water were ground cooked wheat, ground chicken, animal fat, and ground yellow corn; the remaining ingredients were molasses, vitamin mixture, calcium carbonate, dicalcium phosphate, manganese sulfate, and zinc carbonate.…”

Section: Methodsmentioning

confidence: 99%

“…The tuna was incorporated into a nutritionally balanced diet, to eliminate the possibility that nutritional deficiencies might have been involved in a previous report of possible toxic effects in kittens fed a 100% tuna diet [3]. The protocol was similar to that used in a Canadian study by Charbonneau et al [8] using diets containing 35% pike. They fed adult cats a mixture of pike from Lake Winnipeg or a Hg-contaminated Canadian lake to give dietary Hg levels ranging from 0.05 to 2.94 μg/g.…”

mentioning

confidence: 98%

See 1 more Smart Citation

Factors in Fish Modifying Methylmercury Toxicity and Metabolism

Ganther

Sunde

2007

Biol Trace Elem Res

View full text Add to dashboard Cite

We report here some results of a long-term (19 month) study with cats fed methylmercury (MeHg) in nutritionally balanced diets based on fish. By using either freshwater pike (low in Se) or canned tuna (high in Se) as the major protein source, basal diets with low levels of MeHg were prepared having different Se content, all Se being of natural origin. The basal diets produced no signs of toxicity or pathological changes over the l9-month period. In cats fed basal diets spiked with medium or high levels of MeHg, evidence for delayed onset of toxic effects from the added MeHg was observed with the tuna diets compared to pike diets. In brain, muscle, and blood, the activity of GSH peroxidase, a selenoenzyme, was decreased by Hg. In liver, substantial accumulation of Hg with Se occured (molar Hg/Se ratio approximately 1.4 to 1.8) but GSH peroxidase activity was unaffected. We suggest that the coaccumulation of Hg and Se in liver measures the extent to which MeHg has been metabolically transformed by metabolism to Hg++, and inactivated by deposition as a Hg/Se complex of low bioavailability. The accumulation of Hg and Se in liver was much greater in cats fed tuna compared to pike, out of proportion to the relatively small differences in Hg and Se content of the tuna and pike basal diets. Some mechanisms are described by which selenium, vitamin E, and other factors might facilitate MeHg breakdown to inorganic Hg during long term low level exposure to MeHg.

show abstract

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 98%

Factors in Fish Modifying Methylmercury Toxicity and Metabolism

Ganther

Sunde

2007

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Mercury levels in individual animals exceed Hg concentrations causing toxicity, including reduced survival (Eisler, 1987;Zillioux et al, 1993;Scheuhammer, 1991;Thompson, 1996). Also, Hg concentrations in some Florida panther carcasses have exceeded levels associated with Hg toxicity in other feline species (Charbonneau et al, 1974(Charbonneau et al, , 1976. Mercury risks were lowest for raccoons because of limited consumption of the largest, most contaminated fish; however, raccoons may serve as an important pathway of Hg exposure to Florida panthers.…”

Section: Discussionmentioning

confidence: 90%

A Screening Level Probabilistic Risk Assessment of Mercury in Florida Everglades Food Webs

Duvall

Barron

2000

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

“…With a known high absorption rate, MeHg (methyl mercury) is the likely chemical species responsible for trophic migration of Hg in Tims Branch (Berglund et al 1971;Charbonneau et al 1976;Miettinen 1973). Mercury methylation is a concern in Tims Branch due to the dynamic conditions of this system undergoing periods of flooding and drought as these processes are known to increase the methylation process (Brigham et al 2009;Driscoll 1998;Krabbenhoft 1999;Mason et al 2000;Roy et al 2009 a,b).…”

Section: Mercurymentioning

confidence: 99%

Are U, Ni, and Hg an Environmental Risk within a RCRA/CERCLA Unit on the U.S. Department of Energy's Savannah River Site?

Edwards

Gaines

Bryan

et al. 2014

Human and Ecological Risk Assessment: An International Journal

View full text Add to dashboard Cite

The U.S. Department of Energy's Savannah River Site (SRS) is a former nuclear weapon production facility. From 1954From -1985, releases of Al, Cu, Cr, Hg, Ni, Pb, U, and Zn were discharged into the Tims Branch-Steed Pond water system. This study investigates whether metal concentrations in Tims Branch's sediment, biofilm and other biota exceed screening level risk calculations to determine if remedial actions should be pursued for the Contaminants of Potential Concern (U, Ni, Hg). Transfer factors (TFs) were calculated to determine metal concentration changes throughout lower trophic levels and results were compared with sediment benchmarks to create hazard quotients (HQs) to assess risk and a scientific-management decision point. Most TFs for Ni and U from lower to higher trophic level biota were < 1, suggesting no biomagnifications; however HQs > 1 and cumulative distributions showed the majority of the samples exceeded action levels. Elevated TFs and HQs > 1 in the upper trophic levels for Hg indicated a high degree of bioavailability and biomagnification. Monte Carlo resampling analyses supported these empirical results. This system should continue to be closely monitored to ensure that contamination does not move off the SRS.

show abstract

Chronic toxicity of methylmercury in the adult cat interim report

Cited by 53 publications

References 9 publications

Factors in Fish Modifying Methylmercury Toxicity and Metabolism

Factors in Fish Modifying Methylmercury Toxicity and Metabolism

A Screening Level Probabilistic Risk Assessment of Mercury in Florida Everglades Food Webs

Are U, Ni, and Hg an Environmental Risk within a RCRA/CERCLA Unit on the U.S. Department of Energy's Savannah River Site?

Contact Info

Product

Resources

About