Chronic tobacco smoking and neuropsychological impairments: A systematic review and meta-analysis

Conti, Aldo Alberto; McLean, Lianne; Tolomeo, Serenella; Steele, J. Douglas; Baldacchino, Alex

doi:10.1016/j.neubiorev.2018.11.017

Cited by 73 publications

(81 citation statements)

References 97 publications

(99 reference statements)

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“…Interestingly, the dose of nicotine consumed (cigarette per day or pack-years) were not associated with neuropsychological performance in this study, contrasting the main ndings of a recent review conducted by Conti et al (2019), in which several studies included in their review reported a negative link between the number of pack-years and neuropsychological function [2]. This discrepancy in results may be confounded by the considerable variations in the number of pack-years reported across studies (ranging from 4.26 to 73.73) [2].…”

Section: Discussioncontrasting

confidence: 99%

“…The harmful impact of chronic tobacco smoking on physical health is well documented and includes cardiovascular diseases, respiratory diseases, and various forms of cancer [2]. Additionally, chronic smoking is implicated in the pathogenesis of neuropsychological dysfunction and has been directly linked to increased risk of depression and cognitive impairment [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

“…A large number of studies have examined the effects of smoking on neuropsychological function across multiple variables. Compared to healthy controls, chronic smoking was cumulatively reported to have detrimental effects on various neuropsychological domains, including general intellectual abilities, processing speed, attention, memory, cognitive exibility and executive functions [2,3,5]. The effects of nicotine on cognition are believed to vary based on the dose of nicotine used and the onset of regular use.…”

Section: Introductionmentioning

confidence: 99%

“…Based on the current literature, it is di cult to draw solid conclusions on the impact of smoking on neuropsychological function [2]. The in uence of nicotine on speci c domains of cognition is complex and much remains to be known about the smoking impact on neuropsychology and cognition.…”

Section: Introductionmentioning

confidence: 99%

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The negative impact of chronic tobacco smoking on adult neuropsychological function: a case control study

Nadar

Hasan

Alsaleh

2020

Preprint

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Background: The evidence on the effects of chronic tobacco smoking on neuropsychological functions is conflicting. The literature remains limited by inconsistent accounting for potentially confounding biomedical and psychiatric conditions. This study aimed to assess the neuropsychological functions of adult chronic tobacco smokers in comparison to healthy matched-subjects’ controls. Method: The study included 73 smokers and 84 matched-subject non-smoker controls. The data was collected during the year 2019. After an initial interview to collect demographics and smoking profile, the subjects undertook neuropsychological assessments that targeted a wide range of cognitive domains. Results: The performance of smokers was poorer on almost all neuropsychological domains, namely selective attention (p ≤ .001, p =.044), alternating attention (p = .002) working memory (p ≤ .001), Short-term memory (p = .006 and .003), Long-term memory (p ≤ .001), processing accuracy (p ≤ .001), and executive function (p = .011 and .026). Smokers were intact on processing speed. smoking accumulation and the age onset of regular smoking we negatively correlated with neuropsychological function. Conclusion: Our findings add to the growing body of evidence suggesting that chronic tobacco smoking impacts negatively on cognition.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The negative impact of chronic tobacco smoking on adult neuropsychological function: a case control study

Nadar

Hasan

Alsaleh

2020

Preprint

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“…[64], all within the current experimental design and cohort. Performance deficits among cigarette smokers [65] and associated nicotine-induced enhancement manifest in multiple domains, particularly when considering aspects of attention [29]. Whereas nicotine-induced performance enhancement among short-term abstinent smokers represents acute withdrawal reversal, such effects among nonsmokers likely reflects attentional enhancement independent of withdrawal relief [66].…”

Section: Discussionmentioning

confidence: 99%

Habenular and striatal activity during performance feedback are differentially linked with state-like and trait-like aspects of tobacco use disorder

Flannery

Riedel

Poudel

et al. 2019

Preprint

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248 words Manuscript body: 8,724 words Figures: 5 Tables: 0 References: 110 Supplemental Information: 1 file ABSTRACTAlthough tobacco use disorder is linked with functional alterations in the striatum, anterior cingulate cortex (ACC), and insula, preclinical evidence also implicates the habenula as a contributor to negative reinforcement mechanisms maintaining nicotine use. The habenula is a small and understudied epithalamic nucleus involved in reward and aversive processing that is hypothesized to be hyperactive during nicotine withdrawal thereby contributing to anhedonia. In a pharmacologic fMRI study involving administration of nicotine and varenicline, two relatively efficacious cessation aids, we utilized a positive and negative performance feedback task previously shown to differentially activate the striatum and habenula. By administering these nicotinic drugs (vs. placebos) to both overnight abstinent smokers (n=24) and nonsmokers (n=20), we delineated feedbackrelated functional alterations both as a function of a chronic smoking history (trait: smokers vs. nonsmokers) and as a function of drug administration (state: nicotine, varenicline). We observed that smokers showed less ventral striatal responsivity to positive feedback, an alteration not mitigated by drug administration, but rather correlated with higher trait-level addiction severity among smokers and elevated self-reported negative affect across all participants. Conversely, nicotine administration reduced habenula activity following both positive and negative feedback among abstinent smokers, but not nonsmokers; greater habenula activity correlated with elevated abstinence-induced, state-level tobacco craving among smokers and elevated social anhedonia across all participants. These outcomes highlight a dissociation between neurobiological processes linked with the trait of dependence severity and with the state of acute nicotine withdrawal. Interventions simultaneously targeting both aspects may improve currently poor cessation outcomes.One-sentence teaser: In a pharmacological fMRI study, e dissociate brain alterations in the habenula linked with nicotine withdrawal and striatal alterations linked with addiction.

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Risk factors for neurocognitive impairment, emotional distress, and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study

van der Plas,

Darji,

Srivastava

et al. 2024

Cancer

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BackgroundPrevalence and risk of poor psychological outcomes following rhabdomyosarcoma (RMS) are not well‐established.MethodsParticipants in this cross‐sectional, case‐control study (n = 713 survivors, 42.5% female; mean [SD] age, 30.5 [6.6] years; n = 706 siblings, 57.2% female; mean age, 32.8,[7.9] years) completed measures of neurocognition, emotional distress, and health‐related quality of life (HRQOL). Multivariable logistic regression models identified treatments, health behaviors, and chronic conditions associated with impairment.ResultsRelative to siblings, more survivors reported neurocognitive impairment (task efficiency: 21.1% vs. 13.7%, emotional regulation: 16.7% vs. 11.0%, memory: 19.3% vs. 15.1%), elevated emotional distress (somatic distress: 12.9% vs. 4.7%, anxiety: 11.7% vs. 5.9%, depression: 22.8% vs. 16.9%) and poorer HRQOL (physical functioning: 11.1% vs. 2.8%, role functioning due to physical problems: 16.8% vs. 8.2%, pain: 17.5% vs. 10.0%, vitality: 22.3% vs. 13.8%, social functioning: 14.4% vs. 6.8%, emotional functioning: 17.1% vs. 10.6%). Cranial radiation increased risk for impaired task efficiency (odds ratio [OR], 2.30; 95% confidence interval [CI], 1.14–4.63), whereas chest and pelvic radiation predicted increased risk of physical functioning (OR, 2.68; 95% CI, 1.16–6.21 and OR, 3.44; 95% CI, 1.70–6.95, respectively). Smoking was associated with impaired task efficiency (OR, 2.06; 95% CI, 1.14–3.70), memory (OR, 2.23; 95% CI, 1.26–3.95), anxiety (OR, 2.71; 95% CI, 1.36–5.41) and depression (OR, 1.77; 95% CI, 1.01–3.11). Neurologic conditions increased risk of anxiety (OR, 2.30; 95% CI, 1.04–5.10), and hearing conditions increased risk of depression (OR, 1.79; 95% CI, 1.05–3.03). Neurologic and hearing conditions, respectively, were associated with impaired memory (OR, 2.44; 95% CI, 1.20–4.95 and OR, 1.87; 95% CI, 1.05–3.35) and poor health perception (OR, 2.62; 95% CI, 1.62–1.28 and OR, 2.33; 95% CI, 1.34–4.06).ConclusionsRMS survivors are at significant risk for poor psychological outcomes. Advancing therapies for local control, smoking cessation, and managing chronic medical conditions may mitigate poor outcomes following RMS.

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Chronic tobacco smoking and neuropsychological impairments: A systematic review and meta-analysis

Cited by 73 publications

References 97 publications

The negative impact of chronic tobacco smoking on adult neuropsychological function: a case control study

The negative impact of chronic tobacco smoking on adult neuropsychological function: a case control study

Habenular and striatal activity during performance feedback are differentially linked with state-like and trait-like aspects of tobacco use disorder

Risk factors for neurocognitive impairment, emotional distress, and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study

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