Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and massive hemoptysis: The rationale for bronchial artery embolization

Clements, Warren; Venn, Georgina; McGiffin, David; Joseph, Tim; Goh, Gerard S; Whitford, Helen; Keating, D.

doi:10.1016/j.rmed.2022.106784

Cited by 5 publications

(9 citation statements)

References 12 publications

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“…This study was conducted in Japan by a center specializing in hemoptysis. In contrast, the smallest sample size was found in Clements et al, 2022 [72], with only three patients. Finally, the majority of studies (26/30) used bronchial artery embolization for managing massive hemoptysis.…”

Section: Study Characteristics 321 Major Characteristics Of the Inclu...mentioning

confidence: 85%

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Which Is the Best Way to Treat Massive Hemoptysis? A Systematic Review and Meta-Analysis of Observational Studies

Karlafti,

Tsavdaris,

Kotzakioulafi

et al. 2023

JPM

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Introduction: Hemoptysis is one of the most common symptoms of respiratory system diseases. Common causes include bronchiectasis, tumors, tuberculosis, aspergilloma, and cystic fibrosis. The severity of hemoptysis varies from mild to moderate to massive hemoptysis and can easily lead to hemodynamic instability and death from suffocation or shock. Nevertheless, the most threatening hemoptysis that is presented to the emergency department and requires hospitalization is the massive one. In these cases, today, the most common way to manage hemoptysis is bronchial artery embolization (BAE). Methods: A systematic literature search was conducted in PubMed and Scopus from January 2017 (with the aim of selecting the newest possible reports in the literature) until May 2023 for studies reporting massive hemoptysis. All studies that included technical and clinical success rates of hemoptysis management, as well as rebleeding and mortality rates, were included. A proportional meta-analysis was conducted using a random-effects model. Results: Of the 30 studies included in this systematic review, 26 used bronchial artery embolization as a means of treating hemoptysis, with very high levels of both technical and clinical success (greater than 73.7% and 84.2%, respectively). However, in cases where it was not possible to use bronchial artery embolization, alternative methods were used, such as dual-vessel intervention (80% technical success rate and 66.7% clinical success rate), customized endobronchial silicone blockers (92.3% technical success rate and 92.3% clinical success rate), antifibrinolytic agents (50% clinical success rate), and percutaneous transthoracic embolization (93.1% technical success rate and 88.9% clinical success rate), which all had high success rates apart from antifibrinolytic agents. Of the 2467 patients included in these studies, 341 experienced rebleeding during the follow-up period, while 354 other complications occurred, including chest discomfort, fever, dysphagia, and paresis. A total of 89 patients died after an episode of massive hemoptysis or during the follow-up period. The results of the meta-analysis showed a pooled technical success of bronchial artery embolization equal to 97.22% and a pooled clinical success equal to 92.46%. The pooled recurrence was calculated to be 21.46%, while the mortality was 3.5%. These results confirm the ability of bronchial artery embolization in the treatment of massive hemoptysis but also emphasize the high rate of recurrence following the intervention, as well as the risk of death. Conclusion: In conclusion, massive hemoptysis can be treated with great clinical and technical success using bronchial artery embolization, reducing mortality. Mortality has now been reduced to a small percentage of cases.

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Section: Study Characteristics 321 Major Characteristics Of the Inclu...mentioning

confidence: 85%

“…A proportional meta-analysis was performed for all studies that used a common mode of management of massive hemoptysis, that is, BAE, and provided relevant data [45][46][47][48][49][50][51][52][53][54]56,57,[59][60][61][62][63][64]66,[68][69][70][71][72]74].…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

Which Is the Best Way to Treat Massive Hemoptysis? A Systematic Review and Meta-Analysis of Observational Studies

Karlafti,

Tsavdaris,

Kotzakioulafi

et al. 2023

JPM

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Section: Pathophysiologymentioning

confidence: 99%

“…Massive haemoptysis requiring bronchial artery embolisation has been reported in 1–4% of CTEPH patients [ 13 , 14 ]. Only patients with bronchial artery dilation have been shown to be at increased risk of haemoptysis [ 14 ]. There is no robust evidence that medical treatment with riociguat may increase the incidence of haemoptysis in CTEPH patients; however, in those experiencing episodes of haemoptysis, the drug is not recommended [ 15 ].…”

Section: Pathophysiologymentioning

confidence: 99%

Highlights from the International Chronic Thromboembolic Pulmonary Hypertension Congress 2021

et al. 2023

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Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism. It is caused by persistent obstruction of pulmonary arteries by chronic organised fibrotic clots, despite adequate anticoagulation. The pulmonary hypertension is also caused by concomitant microvasculopathy which may progress without timely treatment. Timely and accurate diagnosis requires the combination of imaging and haemodynamic assessment. Optimal therapy should be individualised to each case and determined by an experienced multidisciplinary CTEPH team with the ability to offer all current treatment modalities. This report summarises current knowledge and presents key messages from the International CTEPH Conference, Bad Nauheim, Germany, 2021. Sessions were dedicated to 1) disease definition; 2) pathophysiology, including the impact of the hypertrophied bronchial circulation, right ventricle (dys)function, genetics and inflammation; 3) diagnosis, early after acute pulmonary embolism, using computed tomography and perfusion techniques, and supporting the selection of appropriate therapies; 4) surgical treatment, pulmonary endarterectomy for proximal and distal disease, and peri-operative management; 5) percutaneous approach or balloon pulmonary angioplasty, techniques and complications; and 6) medical treatment, including anticoagulation and pulmonary hypertension drugs, and in combination with interventional treatments. Chronic thromboembolic pulmonary disease without pulmonary hypertension is also discussed in terms of its diagnostic and therapeutic aspects.

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“…Importantly, it is also the rationale for medical therapy in CTEPH. Clinically, the haemoptysis sometimes seen in CTEPH patients is likely associated with the hypertrophied bronchial artery collateral circulation [ 21 ].…”

Section: Pathologymentioning

confidence: 99%

Clinical–radiological–pathological correlation in chronic thromboembolic pulmonary hypertension

Verbelen,

Godinas,

Dorfmüller

et al. 2023

Eur Respir Rev

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Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and potentially life-threatening complication of acute pulmonary embolism. It is characterised by persistent fibro-thrombotic pulmonary vascular obstructions and elevated pulmonary artery pressure leading to right heart failure. The diagnosis is based on two steps, as follows: 1) suspicion based on symptoms, echocardiography and ventilation/perfusion scan and 2) confirmation with right heart catheterisation, computed tomography pulmonary angiography and, in most cases, digital subtraction angiography. The management of CTEPH requires a multimodal approach, involving medical therapy, interventional procedures and surgical intervention. This clinical–radiological–pathological correlation paper illustrates the diagnostic and therapeutic management of two patients. The first had chronic thromboembolic pulmonary disease without pulmonary hypertension at rest but with significant physical limitation and was successfully treated with pulmonary endarterectomy. The second patient had CTEPH associated with splenectomy and was considered unsuitable for surgery because of exclusive subsegmental lesions combined with severe pulmonary hypertension. The patient benefited from multimodal treatment involving medical therapy followed by multiple sessions of balloon pulmonary angioplasty. Both patients had normalised functional capacity and pulmonary haemodynamics 3–6 months after the interventional treatment. These two examples show that chronic thromboembolic pulmonary diseases are curable if diagnosed promptly and referred to CTEPH centres for specialist treatment.

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Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and massive hemoptysis: The rationale for bronchial artery embolization

Cited by 5 publications

References 12 publications

Which Is the Best Way to Treat Massive Hemoptysis? A Systematic Review and Meta-Analysis of Observational Studies

Which Is the Best Way to Treat Massive Hemoptysis? A Systematic Review and Meta-Analysis of Observational Studies

Highlights from the International Chronic Thromboembolic Pulmonary Hypertension Congress 2021

Clinical–radiological–pathological correlation in chronic thromboembolic pulmonary hypertension

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