Chronic testosterone cypionate therapy in men with secondary impotence

Nankin, Howard R.; Lin, T.; Osterman, Juraj

doi:10.1016/s0015-0282(16)49529-4

Cited by 39 publications

(29 citation statements)

References 22 publications

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“…It has also been shown that even one dosage of supraphysiological AAS injection could cause euphoria in patients, which makes them feel less pain and also develops a proportional tolerance towards the new circumstances in the early post-operative phase, which is in line with our observation [12,26,27].…”

Section: Discussionsupporting

confidence: 90%

“…These observations have been directed towards body strength, functional performance, sexual functioning, libido, erectile function, mood, memory, exercise-induced coronary ischaemia, angina pectoralis, bone mineral density, self-perceived functional status, wound healing and quality of life [10][11][12]17,18,[23][24][25][26][27][28][29][30]. For instance, Sih et al in 1997 conducted a trial on 32 hypogonadal patients and administrated testosterone versus placebo.…”

Section: Discussionmentioning

confidence: 99%

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Anabolic-androgenic steroid effects on early morbid symptoms after open prostatectomy: A pilot study

et al. 2008

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Anabolic-androgenic steroid effects on early morbid symptoms after open prostatectomy: A pilot study

et al. 2008

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“…In a small double-blind study with crossover design in 10 aging men with erectile dysfunction of at least 6-month duration and moderately low serum testosterone levels, administration of 200 mg testosterone cypionate im every 2 wk for 12 wk significantly improved the patients' perception of sexual function compared with placebo treatment (489). In the study by Snyder et al (468), 3-yr testosterone administration by scrotal patch to elderly men with normal or moderately low serum testosterone was without effect on an average score for four questions on sexual function.…”

Section: Sexual Functionmentioning

confidence: 97%

The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications

2005

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Aging in men is accompanied by a progressive, but individually variable decline of serum testosterone production, more than 20% of healthy men over 60 yr of age presenting with serum levels below the range for young men. Albeit the clinical picture of aging in men is reminiscent of that of hypogonadism in young men and decreased testosterone production appears to play a role in part of these clinical changes in at least some elderly men, the clinical relevancy of the age-related decline in sex steroid levels in men has not been unequivocally established. In fact, minimal androgen requirements for elderly men remain poorly defined and are likely to vary between individuals. Consequently, borderline androgen deficiency cannot be reliably diagnosed in the elderly, and strict differentiation between "substitutive" and "pharmacological" androgen administration is not possible. To date, only a few hundred elderly men have received androgen therapy in the setting of a randomized, controlled study, and many of these men were not androgen deficient. Most consistent effects of treatment have been on body composition, but to date there is no evidence-based documentation of clinical benefits of androgen administration to elderly men with normal or moderately low serum testosterone in terms of diminished morbidity or of improved survival or quality of life. Until the long-term risk-benefit ratio for androgen administration to elderly is established in adequately powered trials of longer duration, androgen administration to elderly men should be reserved for the minority of elderly men who have both clear clinical symptoms of hypogonadism and frankly low serum testosterone levels.

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“…For this reason, the most frequent test during evaluation of impotence is T measurement and T therapy for men with ED, even if they are not specifically hypogonadal, is not uncommon. However, while past papers of clinical response to androgens in the treatment of hypogonadal impotent men reported satisfactory results [37, 38], it has recently been found disappointing, except in patients with severe hypogonadism [39]. In fact, careful analysis of the data now appears to confirm that the threshold for impaired libido and altered erectile function seems to be relatively low, with concentrations of T <250 ng/dl required to reliably show this dysfunction.…”

Section: Psychosomatic Impairment Of the Hypothalamic-pituitary-gonadmentioning

confidence: 99%

Sexual Symptoms in Endocrine Diseases: Psychosomatic Perspectives

Balercia¹,

Boscaro²,

Lombardo

et al. 2007

Psychother Psychosom

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Background: Not only the most frequent causes of endocrine sexual dysfunction, such as hypogonadism and hyperprolactinemia, but almost all extragonadal endocrinopathies (hyper- and hypothyroidism, hyper- and hypocortisolism, steroidal secreting tumors, etc.) may have a greater or lesser effect on sexual function. Methods: We analyzed scientific literature on the correlations between hormones and sexual behavior, analyzing the most important issue from a practical point of view. The aim of this review article was thus to summarize the sexual symptoms that may be observed with endocrine diseases. Results: Hormones directly or indirectly regulate all human sexual functions (desire, erection/lubrication, ejaculation, orgasm). Some sexual symptoms may occur as a psychosomatic consequence of hormonal impairment. However, in other cases, endocrine failure may be generated by the psychosomatic involvement. Conclusions: The endocrinologist, as an expert in body chemistry, is ideally positioned to identify and evaluate the full range of medical, physical, and psychiatric problems disrupting sexual function.

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Chronic testosterone cypionate therapy in men with secondary impotence

Cited by 39 publications

References 22 publications

Anabolic-androgenic steroid effects on early morbid symptoms after open prostatectomy: A pilot study

Anabolic-androgenic steroid effects on early morbid symptoms after open prostatectomy: A pilot study

The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications

Sexual Symptoms in Endocrine Diseases: Psychosomatic Perspectives

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