Chronic T-cell lymphocytosis with neutropenia: report of a case studied with monoclonal antibody

Aisenberg, AC; Wilkes, BM; Nl, Harris; Ault, KA; Rw, Carey

doi:10.1182/blood.v58.4.818.bloodjournal584818

Cited by 15 publications

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“…The suppressive effects of normal activated T cells bearing the receptors for the Fc fragment of IgG on autologous and allogeneic marrow cells have also been demonstrated (32). Recent studies suggested that the OKT8 population of lymphocytes may be responsible for the granulocytopenia in patients with lymphoproliferative disorders (33). The same subset of T lymphocytes may possibly be related to the suppression of granulopoiesis in patients with SLE.…”

Section: Discussionmentioning

confidence: 99%

Granulopoiesis in systemic lupus erythematosus

Yamasaki

Niho

Yanase

1983

Arthritis & Rheumatism

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The pathogenesis of granulopoietic failure in systemic lupus erythematosus (SLE) was studied. In 16 Japanese women with SLE, a decreased number of granulocyte/monocyte progenitor cells (CFU‐C) in the bone marrow was demonstrated, and the number of CFU‐C correlated significantly with the peripheral blood granulocyte/monocyte count. The peripheral and bone marrow T lymphocytes suppressed the colony formation of autologous or allogeneic bone marrow CFU‐C. These findings suggest that the decreased marrow CFU‐C may be due to suppression by T lymphocytes, an event that may play an important role in the pathogenesis of granulopoietic failure in SLE.

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Section: Discussionmentioning

confidence: 99%

Granulopoiesis in systemic lupus erythematosus

Yamasaki

Niho

Yanase

1983

Arthritis & Rheumatism

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“…OKT8+ lymphoproliferative syndromes, mostly because of the heterogeneity of the cell population detected by this monoclonal antibody (23), are extremely difficult to classify. A wide variety of cases of T-cell expansion with suppressorlcytotoxic phenotype has in fact been described, ranging from overt malignancy (T-cell leukaemia/lymphoma) to chronic benign immunoregulatory disorders (8,(25)(26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Functional and multimarker analysis of T‐cell chronic lymphocytic leukaemia

Baldini¹,

Padova

Cortelezzi

et al. 1985

Scandinavian Journal of Haematology

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The morphology, immunophenotype, cytoenzymatic and functional activities of T lymphocytes from 4 patients with chronic lymphoproliferative disease of T‐cell origin were studied. Clonal proliferation was demonstrated by distinctive chromosomal abnormalities involving chromosomes 2 and 14. Patients 1 and 2 were classifiable as OKT4+ T‐cell chronic lymphocytic leukaemia (T‐CLL) and patient 3 as OKT4+/OKT8+ T‐CLL, with helper function in vitro only in patient 1. Patient 4 has low‐grade lymphocytosis with benign clinical course, with cells showing morphology of large granular lymphocytes (LGL), and immunophenotype HNK‐1+, ER+, Fcy receptor+, OKT3+, OKT11+ and OKT8+, as well as natural killer activity, radiosensitive suppressor activity on Ig secretion and responsiveness to PHA; this case was interpreted as LGL leukaemia. This study indicates that a large proportion of cases of true T‐CLL may belong to the OKT4 subset, and that extensive investigations should be made of the lymphocytic OKT8+/Tγ forms to characterize them precisely.

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“…Another proliferation of T cells (chronic T cell lymphocytosis) has been reported on several occasions and seems to be a distinct entity, with a stable course, few symptoms and sometimes with haematopoietic suppression. Aisenberg et al (8) reported a case of chronic T cell lymphocytosis with neutropenia and summarized 7 more such patients. The characteristics common to all the patients described were lymphocytosis, neutropenia, splenomegaly, E rosettes+, Fcy receptors+, high antibody-dependent cytotoxicity and no natural killer activity.…”

Section: Discussionmentioning

confidence: 99%

“…T cell chronic lymphocytic leukaemia (TCLL) is a rare disorder (1-5% of all CLL cases), usually associated with splenomegaly, sometimes with skin involvement, moderate or high absolute lymphocytosis, partial involvement of the bone marrow and an unfavourable clinical course in most cases ( 1 4 ) . Chronic T cell lymphocytosis (CTCL) on the other hand has been reported on several occasions as a distinct entity with good prognosis, associated with anaemia (5) or neutropenia (6-8), mild absolute lymphocytosis and an increase of the suppressor T cells (OKT8 + , FcTy +) (5)(6)(7)(8)(9). The distinction between TCLL and CTCL is not clear and, in the absence of a clonal chromosomal marker or a frank leukaemic proliferation, the stable clinical picture and the modest lymphocytosis remains in favour of a benign process (2,5).…”

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confidence: 99%

Chronic T cell lymphocytosis with large granular lymphocytes of helper (OKT4) phennoype

Berrébi

Talmor

Vorst

et al. 1985

Scandinavian Journal of Haematology

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A 54‐year‐old asymptomatic male patient was followed for more than 7 y and presented a constant T cell lymphocytosis without skin involvement or bone marrow depression. No clinical or haematological aggravation was noted during this follow‐up. Morphologically, the cells were large granular lymphocytes strongly positive for beta‐D‐glucuronidase, negative for acid phosphatase and with features of T cells on transmission and scanning electron microscopy. The immunological studies of the lymphocytes showed the following parameters: E rosettes+, mouse rosettes‐, SmIg‐, OKT3+, OKT4 +, OKT8‐, OKT6‐, Ia‐, TdT‐, NK‐, HTLV‐, decreased PHA and PWM stimulation, no interleukin 2 production and failure to enhance Ig synthesis in a PWM driven system. The karyotype was normal. This case of chronic T cell lymphocytosis with large granular lymphocytes helper profile and defect of helper function, not reported in the literature, may correspond to a distinct entity in the heterogeneous group of chronic T cell disorders.

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Chronic T-cell lymphocytosis with neutropenia: report of a case studied with monoclonal antibody

Cited by 15 publications

References 0 publications

Granulopoiesis in systemic lupus erythematosus

Granulopoiesis in systemic lupus erythematosus

Functional and multimarker analysis of T‐cell chronic lymphocytic leukaemia

Chronic T cell lymphocytosis with large granular lymphocytes of helper (OKT4) phennoype

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