Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice

Boyce-Rustay, Janel M.; Cameron, Heather A.; Holmes, Andrew

doi:10.1016/j.physbeh.2007.01.024

Cited by 50 publications

(59 citation statements)

References 70 publications

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“…Present data replicate the recent finding that swim stress failed to alter two-bottle EtOH consumption in C57BL/6J mice [5]. By contrast, DBA/2J and BALB/cByJ mice exposed to the same stress showed a marked reduction in EtOH self-administration as compared to C57BL/ 6J.…”

Section: Nih Public Accesssupporting

confidence: 89%

“…Similarly, work examining the effects of stress on sensitivity to the behavioral effects of acute EtOH challenge has not produced a clear consensus [7,16,20,21,26,34,45,48]. Supporting the notion that strain differences may be one factor contributing to this variability, the main finding of the present NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript study was that repeated exposure to swim stress produced alterations in EtOH-related behaviors that were to some extent dependent upon the inbred mouse studied.Present data replicate the recent finding that swim stress failed to alter two-bottle EtOH consumption in C57BL/6J mice [5]. By contrast, DBA/2J and BALB/cByJ mice exposed to the same stress showed a marked reduction in EtOH self-administration as compared to C57BL/ 6J.…”

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confidence: 89%

“…Of note, on some, but not all, assays for anxiety and depression-related behaviors and stress-responsivity, the C57BL/6J strain scores low relative to certain other strains such as BALB/cByJ [3,15,36,56]. We recently reported that repeated exposure (14-days) to forced swim stress in the C57BL/6J inbred strain increased sensitivity to the sedative/ hypnotic and hypothermic effects of EtOH [5]. However, the same stress regime did not alter voluntary EtOH self-administration in a two-bottle free choice test.…”

Section: Nih Public Accessmentioning

confidence: 99%

“…C57BL/6J, DBA/2J and BALB/cByJ mice were exposed to chronic swim stress [5] and twenty-four hours later tested for the sedative/ hypnotic effects of an acute dose of EtOH (4 g/kg) previously shown to increase sensitivity to this measure in C57BL/6J [5]. In a separate cohort, EtOH self-administration was measured in a two-bottle free choice paradigm prior to, during chronic swim stress, and after the cessation of stress.…”

Section: Nih Public Accessmentioning

confidence: 99%

“…Mice were stressed by being placed in a transparent Plexiglas cylinder (20 cm diameter) filled halfway with water (24 ±1°C) for 10 min, as previously described [5,25]. We have previously shown that this stress regime produces a progressive, significant increase in immobility (a putative measure of depression-related behavior) across days, and significant activation of the hypothalamic-pituitary-adrenal axis in C57BL/6J mice [5]. Every 2 days the EtOH and water were changed and the left/right position of the bottles was switched daily to control for any side bias.…”

Section: Nih Public Accessmentioning

confidence: 99%

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Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice

Boyce-Rustay

Janos

Holmes

2008

Behavioural Brain Research

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There is a strong clinical relationship between stress and stress-related disorders and the incidence of alcohol abuse and alcoholism, and this relationship appears to be partly genetic in origin. There are marked strain differences in ethanol (EtOH)-related behaviors and reactivity to stress, but little investigation of the interaction between the two. The present study assessed the effects of chronic exposure to swim stress on EtOH-related behavior in three common inbred strains of mice, C57BL/ 6J, DBA/2J and BALB/cByJ. After establishing baseline (10%) EtOH self-administration in a twobottle free choice test, mice were exposed to daily swim stress for 14 consecutive days and EtOH consumption measured as a percent of baseline both during stress and for 10 days afterwards. A separate experiment examined the effects of 14 days of swim stress on sensitivity to the sedative/ hypnotic effects of an acute injection of 4 g/kg EtOH. Results showed that stress produced a marked and prolonged decrease in EtOH consumption in DBA/2J and BALB/cByJ, but not C57BL/6J mice. By contrast, stress increased sensitivity to the sedative/hypnotic effects of EtOH across all 3 strains. These findings demonstrate that chronic swim stress produces reductions in EtOH self-administration in a strain-dependent manner, and that these effects may be restricted to low-consuming strains. Present data also indicate a dissociation between effects of this stressor on EtOH self-administration and sensitivity to EtOH's sedative/hypnotic effects. In conclusion, strain differences, that are likely in large part genetic in nature, modify the effects of this stressor on EtOH's effects in a behaviorspecific manner. Keywords mouse; strain; ethanol; sedation; gene; drinking; swim stress; preference; two-bottle choice There is a strong epidemiological link between stress-related psychiatric disorders and alcoholism. Individuals suffering from depression or anxiety disorders, conditions often associated with stress, are more likely to abuse alcohol and become alcoholic, and tend to respond less well to therapeutic interventions [8,9,29,54]. Moreover, a history of adverse life events positively correlates with increased rates of alcoholism; although, interestingly, a proportion of individuals become abstinent following stress [19,35,46,51]. These clinic data lend support to the influential hypothesis that stress represent a significant risk factor for alcoholism [12,28]. *Corresponding author: R4N5 AP9A-L018, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, Ph. +1-847-937-2559, Fax +1-847-938-0072, E-mail: janel.boyce-rustay@abbott.com. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered wh...

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Section: Nih Public Accesssupporting

confidence: 89%

supporting

confidence: 89%

Section: Nih Public Accessmentioning

confidence: 99%

Section: Nih Public Accessmentioning

confidence: 99%

Section: Nih Public Accessmentioning

confidence: 99%

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Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice

Boyce-Rustay

Janos

Holmes

2008

Behavioural Brain Research

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Effects of adolescent fluoxetine treatment on fear-, anxiety- or stress-related behaviors in C57BL/6J or BALB/cJ mice

et al. 2008

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Rationale 5-Hydroxytryptamine (5-HT, serotonin) plays a major role in brain ontogeny. Disruption of 5-HT during early postnatal development produces lasting changes in rodent ‘emotion-related’ behaviors. Adverse effects of treatment with serotonin reuptake inhibitor (SRI) antidepressants have been reported in human adolescents. However, the long-term effects of chronic SRI treatment during adolescence in rodents remain unclear. Objectives The objectives of the study are to assess the effects of fluoxetine treatment throughout the adolescent period in measures of fear-, anxiety- and stress-related endpoints in drug-free adults and to examine these effects in two genetic strains of mice differing in baseline stress-and anxiety-related behaviors and sensitivity to SRIs. Materials and methods C57BL/6J and BALB/cJ mice received one of two fluoxetine doses for 4 weeks during adolescence (3–7 weeks old). A separate group of C57BL/6J and BALB/cJ mice received fluoxetine for 4 weeks during adulthood (8–12 weeks old). After a 3-week washout period, mice were tested for anxiety-like behaviors (novel open field, elevated plus-maze), fear conditioning and extinction, and stress-related responses to forced swim, as well as serotonin brain levels. Results Adolescent fluoxetine treatment did not increase adult measures of anxiety-, fear- or stress-related behaviors, or brain serotonin levels. The same duration of treatment in adulthood also had no effects on these measures when tested after a 3-week washout period. Conclusions In clear contrast with emotion-related abnormalities caused by preadolescent fluoxetine treatment or genetic inactivation of fluoxetine’s pharmacological target, the 5-HT transporter, fluoxetine treatment throughout mouse adolescence did not produce detectable, lasting abnormalities in either “high” or “low anxiety” inbred mouse strains.

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Effects of stress on alcohol drinking: a review of animal studies

López²,

2011

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Rationale While stress is often proposed to play a significant role in influencing alcohol consumption, the relationship between stress and alcohol is complex and poorly understood. Over several decades, stress effects on alcohol drinking have been studied using a variety of animal models and experimental procedures, yet this large body of literature has generally produced equivocal results. Objectives This paper reviews results from animal studies in which alcohol consumption is evaluated under conditions of acute/sub-chronic stress exposure or models of chronic stress exposure. Evidence also is presented indicating that chronic intermittent alcohol exposure serves as a stressor that consequently influences drinking. Results The effects of various acute/sub-chronic stress procedures on alcohol consumption have generally been mixed, but most study outcomes suggest either no effect or decreased alcohol consumption. In contrast, most studies indicate that chronic stress, especially when administered early in development, results in elevated drinking later in adulthood. Chronic alcohol exposure constitutes a potent stressor itself, and models of chronic intermittent alcohol exposure reliably produce escalation of voluntary alcohol consumption. Conclusions A complex and dynamic interplay among a wide array of genetic, biological, and environmental factors govern stress responses, regulation of alcohol drinking, and the circumstances in which stress modulates alcohol consumption. Suggestions for future directions and new approaches are presented that may aid in developing more sensitive and valid animal models that not only better mimic the clinical situation, but also provide greater understanding of mechanisms that underlie the complexity of stress effects on alcohol drinking.

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Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice

Cited by 50 publications

References 70 publications

Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice

Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice

Effects of adolescent fluoxetine treatment on fear-, anxiety- or stress-related behaviors in C57BL/6J or BALB/cJ mice

Effects of stress on alcohol drinking: a review of animal studies

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