Chronic suppurative lung disease with associated vasculitis

Bruce, Ian N.; McAteer, James A.; Gardiner, Philip; McFarland, Robert; Sloan, James M.; Bell, A. L.

doi:10.1136/pgmj.71.831.24

Cited by 17 publications

(16 citation statements)

References 23 publications

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“…Thus, long-standing CAD followed by onset of ANCAassociated vasculitis strongly supports the "ANCA-cytokine sequence hypothesis" (6). CAD could cause the neutrophil destruction, which is followed by ANCA elevation (3).…”

Section: Discussionsupporting

confidence: 52%

“…An association between chronic airway diseases (CAD) such as bronchiectasis (BE), diffuse panbronchiolitis (DPB) and sinobronchial syndrome (SBS), and vasculitis has been reported. To our knowledge, there have been 22 reported cases of CAD complicating systemic vasculitis (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). In these reported cases, CAD preceded the onset of vasculitis.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Sinobronchial Syndrome Complicated with Myeloperoxidase Antineutrophil Cytoplasmic Antibody Associated Vasculitis: Review of the Literature

et al. 2012

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We report a case of long-standing sinobronchial syndrome complicated by microscopic polyangiitis (MPA) during the clinical course. The patient showed a mild elevation of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) 17 months prior to the diagnosis of MPA. Subsequently, her MPO-ANCA level gradually became more elevated, and finally her MPO-ANCA level peaked when purpura appeared. Histologic examination of the skin biopsy was consistent with leukocytoclastic vasculitis. Based on the pathological and clinical findings, a diagnosis of MPA was made. Corticosteroid therapy finally led to a remission of MPA with normalized MPO-ANCA titers.

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Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

A Case of Sinobronchial Syndrome Complicated with Myeloperoxidase Antineutrophil Cytoplasmic Antibody Associated Vasculitis: Review of the Literature

et al. 2012

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“…Somereports suggested the association of chronic airway infection with vasculitis, while Miyamoto et al reported a case of diffuse panbronchiolitis in which developed MPOANCAexpression was associated vasculitis (3). As for the development of MPO-ANCA associated vasculitis, there is a hypothesis called the ANCA-cytokine sequence theory (9). According to this theory, MPO-ANCA leads to activation of neutrophils and degranulation by inducing inflammatory cytokines and this finally results in vascular damage.…”

Section: Discussionmentioning

confidence: 99%

Bronchiectasis with Myeloperoxidase Antineutrophil Cytoplasmic Antibody and Bactericidal/Permeability-Increasing Protein Antineutrophil Cytoplasmic Antibody.

et al. 1999

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A 56-year-old womanwas hospitalized for recurrent hemoptysis. She had been suffering from bronchiectasis for 4 years. Pseudomonas aeruginosa was persistently detected in her sputum. Serum was positive for Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) and bactericidal/permeability-increasing protein antineutrophil cytoplasmic antibody (BPI-ANCA).She underwent lung resection. Histopathologically, the resected lung showed bronchiectasis with pulmonary fibrosis but did not show vasculitis. Her serum became negative for the ANCAs after the operation. To date, she has no recurrence of hemoptysis. Wediscuss this case of bronchiectasis with MPO-ANCA and BPI-ANCA and suggest a possible role for ANCAs in chronic airway infection. (Internal Medicine 38: 813-816, 1999)

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“…Microscopic polyangiitis with MPO-ANCA is considered to be frequently associated with necrotizing glomerulonephritis and pulmonary hemorrhage. There are several reports of the coexistence of systemic vasculitis and chronic suppurative lung diseases, including diffuse panbronchiolitis (DPB), bronchiectasis, and cystic fibrosis (3)(4)(5)(6)(7)(8). Chronic respiratory infection may play a role in the pathogenesis of ANCA-associated vasculitis syndrome.…”

Section: Introductionmentioning

confidence: 99%

Microscopic Polyangiitis Associated with Diffuse Panbronchiolitis

et al. 2004

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There are several case reports of systemic vasculitis associated with chronic suppurative lung diseases. We describe a 46-year-old female, previously diagnosed as having diffuse panbronchiolitis (DPB), presenting with hemosputum and dyspnea. Her serum titer of MPO-ANCA was positive together with a high titer of BPI-ANCA. Chest X-ray and chest CT scan showed pulmonary hemorrhage, and the renal biopsy specimen revealed necrotizing, crescentic glomerulonephritis. She was diagnosed as having ANCA-associated vasculitis, and more specifically, microscopic polyangiitis accompanied by DPB. She was treated with methylprednisolone pulse therapy, followed by intravenous cyclophosphamide. This case suggested a possible association with chronic bacterial infection, which may play a role in the pathogenesis of ANCA-associated vasculitis.

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Chronic suppurative lung disease with associated vasculitis

Cited by 17 publications

References 23 publications

A Case of Sinobronchial Syndrome Complicated with Myeloperoxidase Antineutrophil Cytoplasmic Antibody Associated Vasculitis: Review of the Literature

A Case of Sinobronchial Syndrome Complicated with Myeloperoxidase Antineutrophil Cytoplasmic Antibody Associated Vasculitis: Review of the Literature

Bronchiectasis with Myeloperoxidase Antineutrophil Cytoplasmic Antibody and Bactericidal/Permeability-Increasing Protein Antineutrophil Cytoplasmic Antibody.

Microscopic Polyangiitis Associated with Diffuse Panbronchiolitis

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