Chronic stress sensitizes amphetamine-elicited 50-kHz calls in the rat: Dependence on positive affective phenotype and effects of long-term fluoxetine pretreatment

Vares, Marten; Metelitsa, Mait; Kõiv, Kristi; Kaldmäe, Margit; Laugus, Karita; Tiitsaar, Kai; Shimmo, Ruth; Harro, Jaanus

doi:10.1016/j.pbb.2018.05.014

Cited by 6 publications

(4 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…affective regulation. We have obtained similar results earlier in studies on the trait of positive affectivity, where rats with higher positive affectivity (expressed as persistently high 50-kHz response to tickling) developed a cross-sensitization in 50-kHz USVs between chronic stress and subsequent repeated amphetamine administration (Vares et al, 2018). Furthermore, rats characterised with lower positive affectivity showed suppression of amphetamine induced 50-kHz calling after experiencing chronic stress (Kõiv et al, 2016).…”

Section: Discussionsupporting

confidence: 85%

“…Previous work has suggested that 50-kHz USVs and locomotor activity have different underlying mechanisms (Burgdorf et al, 2001; Knutson et al, 2002), and we have demonstrated that increase in either 50-kHz calling or locomotor activity is not necessarily accompanied by the other in response to repeated amphetamine (Vares et al, 2018) while both of these behavioural responses are dependent on the activation of the nucleus accumbens (Dreher and Jackson, 1989; Thompson et al, 2006). In locomotor activity, sensitization to repeated amphetamine was expressed in line crossings only in the stressed low sucrose group, but in all groups, except the non-stressed HSuc consuming rats, in rearings.…”

Section: Discussionmentioning

confidence: 57%

“…Thereafter the amphetamine sensitization experiment was conducted. The dose and other conditions were based on previous experiments by ourselves and others (Kõiv et al, 2016; Vares et al, 2018; Wright et al, 2010). The animals were decapitated five days after the last amphetamine administration; five days is a sufficient time for short-term effects of amphetamine on monoamine neurochemistry to disappear and to observe rather the effects of other factors, while the long-term effects potentially involved in amphetamine sensitization should be observable.…”

Section: Methodsmentioning

confidence: 99%

“…Such an effect is termed cross-sensitization, where prior exposure to chronic stress increases the subsequent responsiveness to the effects of psychostimulant drugs (Cruz et al, 2012, Marinelli and Piazza, 2002). On the behavioural level, chronically stressed rats can exhibit increased locomotion (Kalivas and Stewart, 1991) and 50-kHz ultrasonic vocalization activity in response to repeated amphetamine administration (Vares et al, 2018), as well as increased levels of stereotypies (Mason, 1991).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of chronic variable stress on sensitization to amphetamine in high and low sucrose-consuming rats

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background: Individual vulnerability to stress manifests in the interaction of innate properties and environment. There is a growing interest in the individual variability in vulnerability to stress and how it contributes to the development of psychiatric disorders. Intake of palatable substances is often measured in animal models. We have previously demonstrated that the consumption of sucrose solution is a stable trait in rats. Aims: The present study aimed to compare the sensitivity of rats with high vs low liquid sucrose consumption to chronic variable stress and the stress effect on behavioural sensitization to amphetamine. Methods: Male Wistar rats were subjected to a chronic stress regimen and subsequent repeated treatment with amphetamine (1 mg/kg, intraperitoneally). Fifty-kHz ultrasonic vocalizations, locomotor activity and stereotypies were measured. Results: In no-stress baseline conditions, the behavioural response to acute amphetamine was similar in rats with high vs low sucrose consumption. Prior chronic stress potentiated the effect of amphetamine only in rats with high sucrose consumption. Behavioural sensitization to repeated administration of amphetamine was observed in non-stressed rats with lower sucrose preference, but not in the respective stressed group that had increased monoamine turnover in the nucleus accumbens. In contrast, in rats with high sucrose preference the amphetamine sensitization effect was prevalent in stressed rats, but not in non-stressed animals. Interpretation: Chronic stress can change the psychostimulant effect but this depends on the inherent reward sensitivity of the animal. Trait-wise, sucrose intake reflects vulnerability to chronic stress and may interact with the development of addiction.

show abstract

Section: Discussionsupporting

confidence: 85%