Chronic Stress Promotes Cancer Development

Dai, Shirui; Mo, Yongzhen; Wang, Yumin; Xiang, Bo; Liao, Qianjin; Zhou, Ming; Li, Xiaoling; Li, Yong; Wang, Xiong; Li, Guiyuan; Guo, Can; Zeng, Zhaoyang

doi:10.3389/fonc.2020.01492

Cited by 221 publications

(174 citation statements)

References 84 publications

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“…For example, people under stress are more likely to develop some unhealthy behaviors (e.g., excessive drinking, smoking, etc.) or a long-term inflammatory response, which raise the risk for tumorigenesis (Dai et al, 2020). Stress affects various immunological and neurochemical aspects involved in tumorigenesis and cancer progression (Thaker et al, 2006;Feng et al, 2012;Le et al, 2016;Zhou et al, 2016).…”

Section: Stress Promotes Cancer Progressionmentioning

confidence: 99%

Nerves in the Tumor Microenvironment: Origin and Effects

Wang

Chen

et al. 2020

Front. Cell Dev. Biol.

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Studies have reported the vital role of nerves in tumorigenesis and cancer progression. Nerves infiltrate the tumor microenvironment thereby enhancing cancer growth and metastasis. Perineural invasion, a process by which cancer cells invade the surrounding nerves, provides an alternative route for metastasis and generation of tumor-related pain. Moreover, central and sympathetic nervous system dysfunctions and psychological stress-induced hormone network disorders may influence the malignant progression of cancer through multiple mechanisms. This reciprocal interaction between nerves and cancer cells provides novel insights into the cellular and molecular bases of tumorigenesis. In addition, they point to the potential utility of anti-neurogenic therapies. This review describes the evolving cross-talk between nerves and cancer cells, thus uncovers potential therapeutic targets for cancer.

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Section: Stress Promotes Cancer Progressionmentioning

confidence: 99%

Nerves in the Tumor Microenvironment: Origin and Effects

Wang

Chen

et al. 2020

Front. Cell Dev. Biol.

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“…Stress activates the HPA axis and sympathetic nervous system, resulting in neuroendocrinal and immunological changes, which, in turn, promote detrimental neuroinflammatory reactions [ 7 , 177 , 178 , 179 , 180 , 181 ]. Glucocorticoid immunomodulatory action is a key interaction between the HPA axis and neuroimmune system, which allows for coping with any situation that could challenge homoeostasis in the pathogenesis of depression [ 182 , 183 ].…”

Section: Chm Effects On the Neuroendocrine-immune Networkmentioning

confidence: 99%

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Huang

Zhang

2021

Pharmaceuticals

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The neuroimmune and neuroendocrine systems are two critical biological systems in the pathogenesis of depression. Clinical and preclinical studies have demonstrated that the activation of the neuroinflammatory response of the immune system and hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis of the neuroendocrine system commonly coexist in patients with depression and that these two systems bidirectionally regulate one another through neural, immunological, and humoral intersystem interactions. The neuroendocrine-immune network poses difficulties associated with the development of antidepressant agents directed toward these biological systems for the effective treatment of depression. On the other hand, multidrug and multitarget Chinese Herbal Medicine (CHM) has great potential to assist in the development of novel medications for the systematic pharmacotherapy of depression. In this narrative essay, we conclusively analyze the mechanisms of action of CHM antidepressant constituents and formulas, specifically through the modulation of the neuroendocrine-immune network, by reviewing recent preclinical studies conducted using depressive animal models. Some CHM herbal constituents and formulas are highlighted as examples, and their mechanisms of action at both the molecular and systems levels are discussed. Furthermore, we discuss the crosstalk of these two biological systems and the systems pharmacology approach for understanding the system-wide mechanism of action of CHM on the neuroendocrine-immune network in depression treatment. The holistic, multidrug, and multitarget nature of CHM represents an excellent example of systems medicine in the effective treatment of depression.

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“…However, if this situation cannot be resolved immediately (e.g., chronic pain), this self-protecting mechanism might harm the body instead and becomes maladaptive in the long term. Excessive or prolonged activation of the SNS causes muscle tension, headaches, high blood pressure or even promotes the development of cancer [ 31 ]. People who are physically inactive due to a stress state could rather end up with depression.…”

Section: What Is Stress and What Is Its Correlation With Pain?mentioning

confidence: 99%

Pain and Stress Detection Using Wearable Sensors and Devices—A Review

Chen

Abbod

Shieh

2021

Sensors

112

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Pain is a subjective feeling; it is a sensation that every human being must have experienced all their life. Yet, its mechanism and the way to immune to it is still a question to be answered. This review presents the mechanism and correlation of pain and stress, their assessment and detection approach with medical devices and wearable sensors. Various physiological signals (i.e., heart activity, brain activity, muscle activity, electrodermal activity, respiratory, blood volume pulse, skin temperature) and behavioral signals are organized for wearables sensors detection. By reviewing the wearable sensors used in the healthcare domain, we hope to find a way for wearable healthcare-monitoring system to be applied on pain and stress detection. Since pain leads to multiple consequences or symptoms such as muscle tension and depression that are stress related, there is a chance to find a new approach for chronic pain detection using daily life sensors or devices. Then by integrating modern computing techniques, there is a chance to handle pain and stress management issue.

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Chronic Stress Promotes Cancer Development

Cited by 221 publications

References 84 publications

Nerves in the Tumor Microenvironment: Origin and Effects

Nerves in the Tumor Microenvironment: Origin and Effects

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Pain and Stress Detection Using Wearable Sensors and Devices—A Review

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