Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment

He, Xue-Yan; Gao, Yuan; Ng, David; Michalopoulou, Evdokia; George, Shanu; Adrover, Jose M.; Sun, Lijuan; Albrengues, Jean; Daßler-Plenker, Juliane; Han, Xiao; Wan, Ledong; Wu, Xiaoli Sky; Shui, Longling S.; Huang, Yu-Han; Liu, Bodu; Su, Chang; Spector, David L.; Vakoc, Christopher R.; Van Aelst, Linda; Egeblad, Mikala

doi:10.1016/j.ccell.2024.01.013

Cited by 18 publications

(1 citation statement)

References 79 publications

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“…These psychological challenges often intertwine with physical symptoms, compounding the burden of each ( 99 ). Several studies have linked stress-related psychosocial factors to cancer mortality ( 100 ), with recent work beginning to uncover the cellular and molecular mechanisms at play ( 101 ).…”

Section: Psychosocial and Societal Factors Contributing To The Deteri...mentioning

confidence: 99%

Why do patients with cancer die?

Boire,

Burke,

Cox

et al. 2024

Nat Rev Cancer

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Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. A large number of patients with cancer experience reduced life expectancy and have metastatic disease at time of death. However, the more precise causes of mortality and patient deterioration prior to death remain poorly understood. This scarcity of information, in particular the lack of mechanistic insights, presents a challenge for the development of novel treatment strategies to improve the quality of , and potentially extend life, for patients with late-stage cancer. In addition, earlier deployment of existing strategies to prolong quality of life is highly desirable. In this Roadmap, we review the proximal causes of mortality in patients with cancer, discuss current knowledge about the inter-connections between mechanisms that contribute to mortality, before finally proposing new and improved avenues for data collection, research, and the development of treatment strategies that may improve patients’ quality and duration of life.

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Section: Psychosocial and Societal Factors Contributing To The Deteri...mentioning

confidence: 99%

Why do patients with cancer die?

Boire,

Burke,

Cox

et al. 2024

Nat Rev Cancer

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Imaging and Therapy of Tumors Based on Neutrophil Extracellular Traps

Hao,

Liu,

Wang

et al. 2024

Small Science

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Neutrophil extracellular traps (NETs) formed by neutrophils are netlike scaffolds that mainly contain DNA and a variety of granule proteins. Many stimuli can lead to the NET formation through independent molecular pathways. Clinically, the abundance of NETs is correlated with poor tumor prognosis. The biological actions of NETs are complex and diverse, including promoting tumor progression, awakening the dormant cancer cells, and resulting in immunosuppression in support of tumor growth and metastasis. Therefore, NET‐associated pathological processes provide an important clue for both diagnostic imaging and alternative therapies for many kinds of cancers. In recent years, scientists’ efforts have focused on developing novel imaging probes to visualize NETs and therapeutic strategies by degrading NETs or inhibiting its formation to block their pro‐tumoral functions. In this review, the development and evaluation of NETs‐targeted imaging and intervention progress for tumor therapy are focused on.

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Cancer treatments as paradoxical catalysts of tumor awakening in the lung

Nicolas,

Kosmider,

Cukierman

et al. 2024

Cancer Metastasis Rev

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Much of the fatality of tumors is linked to the growth of metastases, which can emerge months to years after apparently successful treatment of primary tumors. Metastases arise from disseminated tumor cells (DTCs), which disperse through the body in a dormant state to seed distant sites. While some DTCs lodge in pre-metastatic niches (PMNs) and rapidly develop into metastases, other DTCs settle in distinct microenvironments that maintain them in a dormant state. Subsequent awakening, induced by changes in the microenvironment of the DTC, causes outgrowth of metastases. Hence, there has been extensive investigation of the factors causing survival and subsequent awakening of DTCs, with the goal of disrupting these processes to decrease cancer lethality. We here provide a detailed overview of recent developments in understanding of the factors controlling dormancy and awakening in the lung, a common site of metastasis for many solid tumors. These factors include dynamic interactions between DTCs and diverse epithelial, mesenchymal, and immune cell populations resident in the lung. Paradoxically, among key triggers for metastatic outgrowth, lung tissue remodeling arising from damage induced by the treatment of primary tumors play a significant role. In addition, growing evidence emphasizes roles for inflammation and aging in opposing the factors that maintain dormancy. Finally, we discuss strategies being developed or employed to reduce the risk of metastatic recurrence.

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Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment

Cited by 18 publications

References 79 publications

Why do patients with cancer die?

Why do patients with cancer die?

Imaging and Therapy of Tumors Based on Neutrophil Extracellular Traps

Cancer treatments as paradoxical catalysts of tumor awakening in the lung

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