Chronic stress, hair cortisol and depression: A prospective and longitudinal study of medical internship

Mayer, Simone; Lopez-Duran, Nestor L.; Sen, Srijan; Abelson, James L.

doi:10.1016/j.psyneuen.2018.03.020

Cited by 105 publications

(79 citation statements)

References 67 publications

(93 reference statements)

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“…Among adolescents in the current sample, those with greater cumulative HPA axis exposure also reported higher depressive symptoms. Although results from one empirical study (Mayer et al, ) and tentative findings from a recent meta‐analysis that included seven studies and a limited sample of 279 participants (Stalder et al, ) have failed to find an association between hair cortisol and depressive measures, the results from the current study are in accord with numerous studies that found an association between hair cortisol and depressive symptoms (e.g. Abell et al, ; Dettenborn, Tietze, Kirschbaum, & Stalder, ; Faresjö et al, ; Stalder et al, ; Wikenius et al, ) and the prevailing models that HPA axis hypersecretion is associated with depression (Miller et al, ).…”

Section: Discussionsupporting

confidence: 84%

The interactive association of proximal life stress and cumulative HPA axis functioning with depressive symptoms

et al. 2019

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Background: Stress is consistently implicated in depression. Using a vulnerabilitystress framework, the hypothalamic-pituitary-adrenal (HPA) axis may be one factor affecting the stress-depression association. However, the interactive influence of recent life stress and HPA axis functioning on depressive symptoms remains unclear.It is particularly important to understand the synergistic association during adolescence, as this is a developmental period associated with a high risk for depression.Methods: A community sample of 58 adolescents (67% female, 59% Caucasian; mean age, 15.07 years) participated. Adolescents completed a well-validated measure of depressive symptoms and a structured life events interview to assess recent life stress. Hair cortisol concentration was obtained to measure cumulative exposure to HPA axis functioning.Results: Recent life stress and cumulative HPA axis exposure measured through hair cortisol were directly associated with higher depressive symptoms. Further, cumulative HPA axis exposure moderated the relationship between recent life stress and depressive symptoms. The recent life stress-depression association occurred for adolescents who experienced average and high, but not low, levels of cumulative HPA axis exposure. Conclusions:The current study builds on prior work and finds both a direct and interactive association of recent life stress and cumulative HPA axis functioning with depressive symptoms during adolescence. Identifying youth who experience high levels of HPA axis exposure is important to prevent the onset of depression.

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Section: Discussionsupporting

confidence: 84%

The interactive association of proximal life stress and cumulative HPA axis functioning with depressive symptoms

et al. 2019

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“…However, a decline in hair cortisol concentration in line with subjective stress was not found. A recent study of healthy participants, newly qualified doctors followed over their year-long internship, found changes in hair cortisol over time but without a direct association with self-reported depression or stress, 38 and the precise relationship between changes in subjective and objective stress markers remains to be determined. Gao et al 39 have suggested that hair cortisol concentrations may react more slowly to changes in psychological stress than subjective measurements, and it is likely that any possible change in the present study might have been observable only some time after the 20-week follow-up period ended.…”

Section: Discussionmentioning

confidence: 99%

Acceptance and Commitment Therapy Reduces Psychological Stress in Patients With Inflammatory Bowel Diseases

et al. 2019

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This article has an accompanying continuing medical education activity, also eligible for MOC credit, on page e16 (https://www. gastrojournal.org/cme/home). Learning Objective: Upon completion of this CME activity, successful learners will be able to (1) evaluate the potential impact of psychological interventions on psychological disability in patient with inflammatory bowel disease and (2) identify current limitations associated with treatments. Gastroenterology 2019;156:935-945 CLINICAL AT period (all P values >.05). Hair cortisol concentrations correlated with stress (r s ¼ 0.205, P ¼ .050) and anxiety (r s ¼ 0.208, P ¼ .046) at baseline but did not change significantly in the ACT group over the study period compared with the control group (P ¼ .831). CONCLUSION: In a randomized controlled trial of patients with IBD, an 8-week ACT therapy course improved stress and other indices of psychological health.ClinicalTrials.gov Identifier: NCT02350920.

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“…Stress-related responses may be cognitive, emotional, behavioral, or physiological. Depending on the type, timing, and severity of exposure to a stressor, the resulting stress may become a risk factor for a number of illnesses, including those of a psychiatric or cardiovascular nature [ 28 , 29 , 30 , 31 , 32 ]. An emergency such as the COVID-19 outbreak might rightly be considered a severe stressor, as it is a new and unexpected situation with a potentially serious impact on health (experienced both personally and through loved ones) that also involves social restrictions [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Predicting Perceived Stress Related to the Covid-19 Outbreak through Stable Psychological Traits and Machine Learning Models

Flesia

Monaro

Mazza

et al. 2020

JCM

218

186

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The global SARS-CoV-2 outbreak and subsequent lockdown had a significant impact on people’s daily lives, with strong implications for stress levels due to the threat of contagion and restrictions to freedom. Given the link between high stress levels and adverse physical and mental consequences, the COVID-19 pandemic is certainly a global public health issue. In the present study, we assessed the effect of the pandemic on stress levels in N = 2053 Italian adults, and characterized more vulnerable individuals on the basis of sociodemographic features and stable psychological traits. A set of 18 psycho-social variables, generalized regressions, and predictive machine learning approaches were leveraged. We identified higher levels of perceived stress in the study sample relative to Italian normative values. Higher levels of distress were found in women, participants with lower income, and participants living with others. Higher rates of emotional stability and self-control, as well as a positive coping style and internal locus of control, emerged as protective factors. Predictive learning models identified participants with high perceived stress, with a sensitivity greater than 76%. The results suggest a characterization of people who are more vulnerable to experiencing high levels of stress during the COVID-19 pandemic. This characterization may contribute to early and targeted intervention strategies.

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Chronic stress, hair cortisol and depression: A prospective and longitudinal study of medical internship

Cited by 105 publications

References 67 publications

The interactive association of proximal life stress and cumulative HPA axis functioning with depressive symptoms

The interactive association of proximal life stress and cumulative HPA axis functioning with depressive symptoms

Acceptance and Commitment Therapy Reduces Psychological Stress in Patients With Inflammatory Bowel Diseases

Predicting Perceived Stress Related to the Covid-19 Outbreak through Stable Psychological Traits and Machine Learning Models

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