Chronic stress deficits in reward behaviour are underlain by low nucleus accumbens dopamine activity during reward anticipation specifically
Chenfeng Zhang,
Redas Dulinskas,
Christian Ineichen
et al.
Abstract:Whilst reward pathologies e.g., anhedonia and apathy, are major and common in stress-related neuropsychiatric disorders, their neurobiological bases and therefore treatment are poorly understood. Functional imaging studies in humans with reward pathology indicate that attenuated BOLD activity in nucleus accumbens (NAc) occurs during reward anticipation/expectancy but not reinforcement; potentially, this is dopamine (DA) related. In mice, chronic social stress (CSS) leads to reduced reward learning and effortfu… Show more
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