Chronic stress and age-related increases in the proinflammatory cytokine IL-6

Kiecolt‐Glaser, Janice K.; Preacher, Kristopher J.; MacCallum, Robert C.; Atkinson, Cathie; Malarkey, William B.; Glaser, Ronald

doi:10.1073/pnas.1531903100

Cited by 1,027 publications

(779 citation statements)

References 56 publications

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“…Russo and colleagues also report caregivers to have greater prevalence of psychiatric disorders than demographically matched non-caregivers (16). Regarding health outcomes, caregivers have been found to have increased inflammation (17)and compromised immune functioning (18)relative to non-caregivers. Further, caregiving status appears to be associated with greater concentrations of stress hormones and antibodies (19), and male caregivers appear at greater risk for coronary heart disease relative to male non-caregivers(20).…”

Section: Objectivementioning

confidence: 99%

A Comparison of Psychosocial Outcomes in Elderly Alzheimer Caregivers and Noncaregivers

Mausbach

Chattillion

Roepke

et al. 2013

The American Journal of Geriatric Psychiatry

122

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Objectives To conduct ananalysis of the stress, coping, and mood consequences of Alzheimer’s caregiving. Design Cross-sectional. Setting Community-based study. Participants Sample included 125 Alzheimer’s caregivers and 60 demographically similar older adults with non-demented spouses (i.e., non-caregivers). Measurements We compared caregivers and non-caregivers on stress, coping, and mood outcomes. We also examined anti-depressant use within the caregiver sample. An emphasis was placed upon effect size differences, including Cohen’s d as well as more clinically meaningful effect sizes. Results Caregivers were significantly more likely to endorse depressive symptoms and to meet clinically significant cutoff for depression (40% for caregivers; 5% for non-caregivers). Approximately 25% of caregivers reported taking anti-depressant medication, although 69% of these continued to experience significant symptoms of depression. Caregivers also utilized fewer positive coping and greater negative coping strategies relative to non-caregivers. Conclusions The number of caregivers will increase dramatically over the next two decades, and caregivers will likely seek care from primary care providers. We provide an overview of the psychological issues facing caregivers so that effective screening and treatment may be recommended.

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Section: Objectivementioning

confidence: 99%

A Comparison of Psychosocial Outcomes in Elderly Alzheimer Caregivers and Noncaregivers

Mausbach

Chattillion

Roepke

et al. 2013

The American Journal of Geriatric Psychiatry

122

View full text Add to dashboard Cite

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“…This could impact on wound healing in two ways: (i) poor foot care and reduced compliance with offloading is more likely in depressed patients [38,95]; (ii) there is substantial evidence that factors such as stress, negative affect and/or lack of social support have adverse consequences for the wound healing response. Stress has been shown to delay wound healing, possibly by altering proinflammatory cytokine production [96,97]. In addition, depressive symptoms might, via the hypothalamic pituitary adrenal and sympathetic adrenal medullary axes, mediate matrix metalloproteinase levels, thereby impacting on wound healing [98].…”

Section: Wound Healing and The Importance Of Offloadingmentioning

confidence: 99%

The diabetic foot: from art to science. The 18th Camillo Golgi lecture

2004

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Diabetic foot ulceration represents a major medical, social and economic problem all over the world. While more than 5% of diabetic patients have a history of foot ulceration, the cumulative lifetime incidence may be as high as 15%. Ethnic differences exist in both ulcer and amputation incidences, with both being less common in patients of Indian subcontinent origin living in the UK. Foot ulceration results from the interaction of several contributory factors, the most important of which is neuropathy. With respect to the management of acute Charcot neuroarthropathy in diabetes, recent studies suggest that bisphosphonates reduce disease activity as judged not only by differences in skin temperature, but also by assessing markers of bone turnover. The use of the total-contact cast is demonstrated in the treatment of acute Charcot feet and of plantar neuropathic ulcers. Histological evidence suggests that pressure relief results in chronic foot ulcers changing their morphological appearance by displaying some features of an acute wound. Thus, repetitive stresses on the insensate foot appear to play a major role in maintaining ulcer chronicity. It is hoped that increasing research activity in foot disease will ultimately result in fewer ulcers and less amputation in diabetes.

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“…Nevertheless, in older individuals, where the immune system is compromised (McElhaney et al 2009), the SASP secreted by senescent cells accumulated in tissues and significantly altered the cellular microenvironment and structure . Studies have suggested a link between senescence and various age-related diseases including primarily cancer (Kiecolt-Glaser et al 2003) and neurodegenerative disorders such as Alzheimer's disease (Bitto et al 2010;Bhat et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli

Maciel-Barón

Morales-Rosales

Aquino-Cruz

et al. 2016

AGE

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Cellular senescence is a multifactorial phenomenon of growth arrest and distorted function, which has been recognized as an important feature during tumor suppression mechanisms and a contributor to aging. Senescent cells have an altered secretion pattern called Senescence-Associated Secretory Phenotype (SASP) that comprises a complex mix of factors including cytokines, growth factors, chemokines, and matrix metalloproteinases. SASP has been related with local inflammation that leads to cellular transformation and neurodegenerative diseases. Various pathways for senescence induction have been proposed; the most studied is replicative senescence due to telomere attrition called replicative senescence (RS). However, senescence can be prematurely achieved when cells are exposed to diverse stimuli such as oxidative stress (stressinduced premature senescence, SIPS) or proteasome inhibition (proteasome inhibition-induced premature senescence, PIIPS). SASP has been characterized in RS and SIPS but not in PIIPS. Hence, our aim was to determine SASP components in primary lung fibroblasts obtained from CD-1 mice induced to senescence by PIIPS and compare them to RS and SIPS. Our results showed important variations in the 62 cytokines analyzed, while SIPS and RS showed an increase in the secretion of most cytokines, and in PIIPS only 13 were incremented. Variations in glutathione-redox balance were also observed in SIPS and RS, and not in PIIPS. All senescence types SASP displayed a pro-inflammatory profile and increased proliferation in L929 mice fibroblasts exposed to SASP. However, the behavior observed was not exactly the same, suggesting that the senescence induction pathway might encompass dissimilar responses in adjacent cells and promote different outcomes.

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Chronic stress and age-related increases in the proinflammatory cytokine IL-6

Cited by 1,027 publications

References 56 publications

A Comparison of Psychosocial Outcomes in Elderly Alzheimer Caregivers and Noncaregivers

A Comparison of Psychosocial Outcomes in Elderly Alzheimer Caregivers and Noncaregivers

The diabetic foot: from art to science. The 18th Camillo Golgi lecture

Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli

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