Chronic somatostatin treatment affects pituitary gonadotrophs, ovaries and onset of puberty in rats

Nestorović, Nataša; Lovren, Mirjana; Sekulić, Milka; Negić, Nataša; Šošić‐Jurjević, Branka; Filipović, Branko; Milošević, Verica

doi:10.1016/j.lfs.2003.07.042

Cited by 11 publications

(5 citation statements)

References 61 publications

(49 reference statements)

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“…This suggests that the period of life when SST-14 is administered determines the effect of this hormone on the non-growing pool of follicles. This is in accordance with our previous findings of enlargement of the non-growing pool of follicles after application of SST-14 chronically to immature, or in multiple doses to infantile and peripubertal females (Nestorović et al 2004a(Nestorović et al , 2008(Nestorović et al , 2011, but not if it was applied in multiple doses to adult rats (Nestorović et al 2001).…”

Section: Discussionsupporting

confidence: 93%

“…It reduced the serum concentration of LH, but did not affect the release of FSH in women with polycystic ovary syndrome (Prelević et al 1990) or in male rats (Starčević et al 2002;Milošević et al 2004). In adult female rats, SST-14 had an inhibitory influence on both types of gonadotropic cells (Nestorović et al 2001(Nestorović et al , 2004a.…”

Section: Introductionmentioning

confidence: 91%

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Long-term effects of somatostatin 14 on the pituitary-ovarian axis in rats

Nestorović

Mn²,

Sl³

et al. 2014

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Abstract. The long-term effects of somatostatin 14 (SST-14) on the pituitary-ovarian axis were examined. Female Wistar rats received 20 µg/100 g b.w. doses subcutaneously twice daily for 5 consecutive days in the infantile (from 11 th to 15 th day) or peripubertal (from 33 rd to 37 th day) period of life. Females treated as infants were killed in the peripubertal (38 th day) or adult period of life (80 th day), and those treated during peripuberty as adults (80 th day). Pituitary follicle-stimulating (FSH), luteinizing (LH) and somatotropic (GH) cells, and ovaries were analyzed by stereology and morphometry. Serum FSH and LH concentrations were determined by RIA. FSH and LH cell volumes were significantly decreased in pituitaries of peripubertal females treated with SST-14 as infants, and in adult females treated during peripuberty. GH cell volume was decreased in all treated rats. In the ovaries, enlargement of the non-growing pool of follicles was detected in adult females treated during peripuberty. SST-14 applied to infant rats did not lead to changes in initial follicular recruitment, but it disturbed follicle growth and development at later stages. It can be concluded that SST-14 exerted long-term inhibitory effects on the pituitary-ovarian axis and GH cells in rats.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 91%

Long-term effects of somatostatin 14 on the pituitary-ovarian axis in rats

Nestorović

Mn²,

Sl³

et al. 2014

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“…For example, an impaired somatotropic axis negatively affects reproduction. Somatostatin treatment inhibits pituitary gonadotropic cells and initial folliculogenesis in the ovaries of infant, peripubertal and adult females [252][253][254][255][256][257]. Polycystic ovary syndrome (PCOS) is of great importance, owing to its prevalence in up to 10% of the women population of reproductive age.…”

Section: Programming Of Hipothalamic-pituitary-gonadal Axismentioning

confidence: 99%

Prenatal Glucocorticoids: Short-Term Benefits and Long-Term Risks

Manojlović‐Stojanoski¹,

Nestorović²,

Milošević³

2012

Glucocorticoids - New Recognition of Our Familiar Friend

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“…In the pituitary, SRIH inhibits GH secretion and also blocks the release of other adenohypophyseal hormones such as thyrotrophin (TSH; Brazeau et al, 1973) prolactin (PRL; Milo{evi} et al, 2000), gonadotrophins (Nestorovi} et al, 2001(Nestorovi} et al, , 2004) and in some cases, adrenocorticotropin (ACTH; Star~evi} et al, 2000). Since its characterization in 1973 (Brazeau et al, 1973), SRIH has attracted much attention because of its wide variety of biological functions in the nervous and other tissues.…”

Section: Introductionmentioning

confidence: 99%

Neonataly applied SRIH-14 has immediate and prolonged inhibitory effect on pituitary GH cells

Nestorović¹,

Terzić²,

Negić³

et al. 2006

Acta vet. (Beogr.)

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The immediate and prolonged effects of neonatal SRIH-14 treatment on pituitary somatotrophs (GH) were investigated. Female rats were injected s.c. twice a day with 20 _g of SRIH-14/100g b.w., for five consecutive days (from 3rd to 7th day of life). Animals were sacrificed at different life periods: at neonatal (8th day), juvenile (16th day), peripubertal (38th day) and adult (80th day) period of life. GH cells were studied using the peroxidase-antiperoxidase immunocytochemical procedure. Morphometry and stereology were used to evaluate changes in the number of GH-immunoreactive cells per unit area, their volume and volume density. After SRIH-14 treatment, the most prominent decrease of all measured parameters was observed in the neonatal period. SRIH-14 induced a significant decrease of GH cell volumes and volume densities in the juvenile, peripubertal and adult periods of life. The number of GH-positive cells was significantly decreased when examined immediately after treatment, but significantly increased in adult females. Body weight, absolute or relative pituitary weights were not affected in any of the examined age groups. These findings suggest that neonatal SRIH-14 treatment exerts a significant immediate and prolonged inhibitory effect on GH cells, but does not affect the growth rate in female rats

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Chronic somatostatin treatment affects pituitary gonadotrophs, ovaries and onset of puberty in rats

Cited by 11 publications

References 61 publications

Long-term effects of somatostatin 14 on the pituitary-ovarian axis in rats

Long-term effects of somatostatin 14 on the pituitary-ovarian axis in rats

Prenatal Glucocorticoids: Short-Term Benefits and Long-Term Risks

Neonataly applied SRIH-14 has immediate and prolonged inhibitory effect on pituitary GH cells

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