Chronic social defeat stress mouse model: Current view on its behavioral deficits and modifications.

Wang, Wang; Liu, Weizhen; Duan, Dong-Xiao; Bai, Hualong; Wang, Ziliang; Xing, Ying

doi:10.1037/bne0000418

Cited by 49 publications

(25 citation statements)

References 89 publications

(164 reference statements)

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“…Social defeat stress promotes depression via synaptic structural changes in the PFC and amygdala [ 54 ], which affect the maturation of newly generated neurons in the hippocampus [ 55 ] and induce neurovascular pathology [ 56 ]. In the current study, obese mice experiencing CSDS showed a significant decline in social functioning and depressive-like behaviors, similar to previous reports [ 57 , 58 ]. In this study, obesity per se did not induce depression, but increased the risk thereof under social stress.…”

Section: Discussionsupporting

confidence: 92%

Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors

Feng

Hou

et al. 2022

J Neuroinflammation

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Background Little is known about how the obesogenic environment influences emotional states associated with glial responses and neuronal function. Here, we investigated glial reactivation and neuronal electrophysiological properties in emotion-related brain regions of high-fat diet (HFD) and ob/ob mice under chronic stress. Methods The glial reactivation and neuronal activities in emotion-related brain regions were analyzed among normal diet mice (ND), HFD mice, wild-type mice, and ob/ob mice. To further activate or inhibit astrocytes in medial prefrontal cortex (mPFC), we injected astrocytes specific Gq-AAV or Gi-AAV into mPFC and ongoing treated mice with CNO. Results The results showed that obesogenic factors per se had no significant effect on neuronal activities in emotion-related brain regions, or on behavioral performance. However, exposure to a chronic stressor profoundly reduced the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) in the mPFC; depressive-like behaviors were seen, accompanied by significant upregulation of astrocyte reactivation. We identified resilient and susceptible mice among chronic social defeat stress-exposed HFD mice. As expected, astrocyte reactivity was upregulated, while neuronal activity was depressed, in the mPFC of susceptible compared to resilient mice. Furthermore, activating astrocytes resulted in similar levels of neuronal activity and depressive-like behaviors between resilient and susceptible mice. Additionally, inhibiting astrocyte reactivation in the mPFC of HFD mice upregulated neuronal activities and inhibited depressive-like behaviors. Conclusions These observations indicate that obesogenic factors increase the risk of depression, and improve our understanding of the pathological relationship between obesity and depression. Graphical Abstract

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Section: Discussionsupporting

confidence: 92%

Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors

Feng

Hou

et al. 2022

J Neuroinflammation

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“…Social conflicts often happen in a human society, which could be unavoidable stress, leading to reduce the quality of life [ 195 ]. Repeated social defeat stress (SDS) conditionings resulting from the exposure of the rodent to multiple aggressive social encounters appear to be relevant stressor mimicking common types of psychosocial stress seen in humans [ 196 , 197 ]. These findings indicate that SDS models could be more relevant for the psychological stress conditions in human life compared with CRS and FS models.…”

Section: Preclinical Models For Psychological Stress and Deep Craniofacial Pain ( Table 1 )mentioning

confidence: 99%

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto

Hasegawa

Piriyaprasath

et al. 2021

Japanese Dental Science Review

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“…Among these environmental factors, stress - understood as adversity/negative experiences in life—has been shown to enhance vulnerability to the rewarding effects of cocaine and other drugs of abuse ( Aguilar et al, 2013 ; Rodríguez-Arias et al, 2013 ; Vannan et al, 2018 ). Among the different types of stress, social stress is currently the most common, and can be modelled in experimental animals with the chronic/repeated social defeat (SD) paradigm, which is known to have predictive power ( Vasconcelos et al, 2015 ; Patel et al, 2019 ; Wang et al, 2021 ; García-Pardo et al, 2022 ). Several studies have shown an increase in the rewarding effects of cocaine in the conditioned place preference (García-Pardo et al, 2019; Calpe-López et al, 2020 ; Montagud-Romero et al, 2020 ) and self-administration ( Holly EN.…”

Section: Introductionmentioning

confidence: 99%

Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice

et al. 2022

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Exposure to intermittent repeated social defeat (IRSD) increases the vulnerability of mice to the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm. According to the “inoculation of stress” hypothesis, a brief period of maternal separation (MS) can provide protection against the negative effects of IRSD. The aim of the present study was to assess whether exposure to a brief episode of MS prevents the subsequent short-term effects of IRSD on depression- and anxiety-like behaviors and to explore its long-term effects on cocaine CPP in mice. Four groups of male C57BL/6 mice were employed; two groups were separated from their mother [6 h on postnatal day (PND) 9], while the other two groups were not (controls). On PND 47, 50, 53 and 56, mice that had experienced MS were exposed to social defeat in the cage of an aggressive resident mouse (MS + IRSD group) or were allowed to explore an empty cage (MS + EXPL group). The same procedure was performed with control mice that had not experienced MS (CONTROL + IRSD and CONTROL + EXPL groups). On PND57-58, all the mice performed the elevated plus maze and the hole-board, social interaction and splash tests. Three weeks after the last episode of defeat, all the mice underwent the CPP procedure with cocaine (1 mg/kg). Irrespective of whether or not MS had taken place, a reduction in open arms measures, dips, and social interaction was observed in mice that experienced IRSD. A higher latency of grooming and acquisition of cocaine-induced CPP were observed only in mice exposed to IRSD alone (CONTROL + IRSD). These results suggest that exposure to a brief episode of stress early in life increases the subsequent resilience of animals to the effects of social stress on vulnerability to cocaine.

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Chronic social defeat stress mouse model: Current view on its behavioral deficits and modifications.

Cited by 49 publications

References 89 publications

Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors

Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice

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