Chronic rhinosinusitis endotypes associate with distinct local cytokine milieus that shape the distribution of innate lymphoid cells

Ko, Young Gyun; Kim, Min Ho; Park, Joo Yong; Gil, Chan Hee; Kim, Tae Soo; Choi, Ji‐Yeob; Chung, Doo Hyun; Kim, Hyun Jik; Kim, Dong Young; Kim, Hye Young

doi:10.1111/all.15300

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“…In addition, tissue remodeling as a result of fibroblast proliferation and collagen deposition also plays an important role in the pathogenesis of CRS 15 . Immune cells comprising macrophages and type 2 innate lymphoid cells also contribute to the inflammatory milieu in CRS 16–19 …”

Section: Introductionmentioning

confidence: 99%

“…15 Immune cells comprising macrophages and type 2 innate lymphoid cells also contribute to the inflammatory milieu in CRS. [16][17][18][19] The sinonasal cavity mucosa is the first site of exposure of the upper respiratory tract to the external environment, and hypoxic conditions undoubtedly play a significant role in the development of CRS. 20,21 A Turkish study investigating the P300 component of electroencephalography-derived event related potentials in 30 male patients with CRSwNP and 30 healthy subjects found that hypoxia can cause disturbances in concentration and attention.…”

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confidence: 99%

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The role of hypoxia in the pathophysiology of chronic rhinosinusitis

Zhong

Seah

Liu

et al. 2022

Allergy

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Chronic rhinosinusitis (CRS) is characterized by inflammation of the nasal cavity and the paranasal sinuses. [1][2][3][4] It has a significant impact on living and working conditions, affecting about 5%-12% of the general population. [5][6][7] Common complaints of such patients include nasal congestion, nasal discharge, altered sense of smell, facial pain, and facial pressure. The United States conservatively estimates that spending on CRS amounts up to $30 billion each year, inevitably creating a huge economic burden on society. 7 From an etiological point of view, CRS can be classified into primary and secondary forms. 8 Primary CRS is characterized by chronic inflammation of the nasal cavity and paranasal sinuses, where an obvious secondary causative factor is absent. Secondary

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Section: Introductionmentioning

confidence: 99%