Chronic Rhinosinusitis, Endothelial Dysfunction, and Atherosclerosis

Elçioğlu, Ömer Celal; Afsar, Barış; Bakan, Ali; Takır, Mümtaz; Özkök, Abdullah; Oral, Alihan; Köstek, Osman; Başçı, Semih; Kanbay, Asiye; Toprak, Aybala Erek; Bahat, Kübra Aydın; Kalcıoğlu, M. Tayyar; Kanbay, Mehmet

doi:10.2500/ajra.2016.30.4325

Cited by 10 publications

(12 citation statements)

References 31 publications

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“…Interestingly, nearly all the comorbidities considering in the current study, mainly the vascular and inflammatory diseases, were significantly prevalent in the surgery-indicated CRS population. The findings further supported the inflammatory nature of CRS and the relationship between CRS and metabolic syndrome, cardiovascular disease, and impaired pulmonary function that proven in previous studies [47,48,49,50,51]. Moreover, the CRS is related to the development of keratopathy according to a previous study using the same database [52] that corresponds to the distribution of the current study.…”

Section: Discussionsupporting

confidence: 91%

The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

Chau

Sun

et al. 2019

IJERPH

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This study investigates the development of glaucoma in subjects with surgery-indicated chronic rhinosinusitis (CRS) by the use of the National Health Insurance Research Database in Taiwan. Individuals that received the functional endoscopic sinus surgery (FESS) with a diagnostic code of CRS were regarded as surgery-indicated CRS and enrolled in the study group. Four non-CRS patients were age- and gender-matched to each patient in the study group. The exclusion criteria included legal blindness, ocular tumor, history of eyeball removal, and previous glaucoma. The outcome was regarded as the development of glaucoma, and conditional logistic regression was used for the statistical analysis, which involved multiple potential risk factors in the multivariate model. A total of 6506 patients with surgery-indicated CRS that received FESS and another 26,024 non-CRS individuals were enrolled after exclusion. The age and gender distributions were identical between the two groups due to matching. There were 108 and 294 glaucoma events in the study group and control group, respectively, during the follow-up period, and the study group had a significantly higher adjusted hazard ratio (1.291, 95% confidential interval: 1.031–1.615). The cumulative probability analysis also revealed a correlation between the occurrence of glaucoma and the CRS disease interval. In the subgroup analysis, the chance of developing open-angle glaucoma and normal-tension glaucoma was significantly higher in the study group than in the control group. In conclusion, the existence of surgery-indicated CRS is a significant risk factor for the development of glaucoma, which correlated with the disease interval.

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Section: Discussionsupporting

confidence: 91%

The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

Chau

Sun

et al. 2019

IJERPH

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“…Increased pro-inflammatory markers and oxidative stress occurs in adipose tissues are the two factors that may play a key role in the incidence of metabolic-related comorbidities among patients with metabolic disorders [ 1 ]. Increased chronic inflammation is associated with increased risk of metabolic disorders, including type 2 diabetes mellitus (T2DM) [ 2 ] and arteriosclerosis, endothelial dysfunction, vascular calcification, increased activity of metalloproteinases, oxidative damage, and degradation of collagen [ 3 – 5 ]. It was reported that metabolic syndrome (MetS ) is associated with a 2-fold increased risk of cardiovascular disease (CVD) over the next 5 to 10 years [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of alpha-lipoic acid supplementation on inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials

et al. 2018

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ObjectiveThis systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of alpha-lipoic acid (ALA) supplementation on the inflammatory markers among patients with metabolic syndrome (MetS) and related disorders.MethodsWe searched the following databases until November 2017: PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. Three reviewers independently assessed study eligibility, extracted data, and evaluated risk of bias of included primary studies. Statistical heterogeneity was assessed using Cochran’s Q test and I-square (I2) statistic. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as the summary effect size.ResultsEighteen trials out of 912 potential citations were found to be eligible for our meta-analysis. The findings indicated that ALA supplementation significantly decreased C-reactive protein (CRP) (SMD = − 1.52; 95% CI, − 2.25, − 0.80; P < 0.001), interlokin-6 (IL-6) (SMD = − 1.96; 95% CI, − 2.60, − 1.32; P < 0.001), and tumor necrosis factor alpha levels (TNF-α) (SMD = − 2.62; 95% CI, − 3.70, − 1.55; P < 0.001) in patients diagnosed with metabolic diseases.ConclusionIn summary, the current meta-analysis demonstrated the promising impact of ALA administration on decreasing inflammatory markers such as CRP, IL-6 and TNF-α among patients with MetS and related disorders.Electronic supplementary materialThe online version of this article (10.1186/s12986-018-0274-y) contains supplementary material, which is available to authorized users.

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“…The idea of looking for a relationship between nasal disease and endothelial dysfunction has already been considered in a recent study by Elcioglu et al [30]. Indeed, they have…”

Section: Discussionmentioning

confidence: 97%

Endothelial Functionality and Echocardiographic Parameters in Patients with Rhinitis and Nasal Polyps

Bulzis¹,

Carbonara²,

Dentamaro³

et al. 2016

Arch Med

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Background: Chronic inflammation is associated with accelerated atherosclerosis, endothelial dysfunction and with early cardiovascular disease. Rhinitis and nasal polyps are inflammatory diseases and the local inflammation is often associated with systemic events that they see as a primary cause the endothelial dysfunction. Studies have shown a higher incidence of cardiovascular events such as stroke, intermittent claudication and myocardial infarction in patients with polyposis and/or rhinitis, but studies that have focused on myocardial injury are few and showed echocardiography as a subclinical deficiency of the right longitudinal functions in patients with nasal polyposis.

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Chronic Rhinosinusitis, Endothelial Dysfunction, and Atherosclerosis

Abstract: CRS is associated with ED and atherosclerosis, as indicated by decreased FMD and increased CIMT in patients with CRS. Further studies are necessary to identify the exact pathophysiologic mechanisms responsible for our findings.

Cited by 10 publications

References 31 publications

The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

The effects of alpha-lipoic acid supplementation on inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials

Endothelial Functionality and Echocardiographic Parameters in Patients with Rhinitis and Nasal Polyps

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