Chronic rhinosinusitis and bacterial biofilms

Ramadan, Hassan H.

doi:10.1097/01.moo.0000193177.62074.fd

Cited by 90 publications

(62 citation statements)

References 67 publications

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“…Coughing and choking (laryngospasm) [7] can be induced by direct refluxate irritation, because the sensitivity in laryngeal sensory endings is up regulated by local inflammation [11,12]. LPR seems to be more common than previously reported in the literature [2], as the present study identified that 18% of patients attending an ENT outpatient department benefited from anti-reflux treatment. The male to female patient ratio was, however, equal, in keeping with previous reports [13].…”

Section: Discussionmentioning

confidence: 59%

“…In addition, it presents with usually normal oesophageal motility, and most patients do not have oesophagitis as is always the case in GERD [6]. Nevertheless, different research groups have proposed different theories for the pathogenesis of LPR, considering it either as a retrograde flow of gastric contents to the laryngopharynx [2], or an abnormal presence of gastric contents above level of the upper oesophageal sphincter [7]. Heterotrophic gastric mucosa in the cervical oesophagus could also play a role in the pathogenesis of LPR, at least in the minor group of patients with laryngitis of the posterior larynx [8].…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have shown that as much as 10 % of the patients presenting to ENT outpatient clinics may suffer from LPR [1,2]. These patients may complain of a broad spectrum of symptoms including dry cough, the need of constantly clearing their throat, post-nasal discharge, foreign body sensation, voice changes etc.…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis and Management of Laryngo-Pharyngeal Reflux

Alam¹,

Vlastarakos

2012

Indian J Otolaryngol Head Neck Surg

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The aim of the present paper was to analyze laryngo-pharyngeal reflux (LPR) manifestations in ENT patients, and present a diagnostic and treatment algorithm for appropriate management. Retrospective chart review of 150 patients, who had initially presented with symptoms suggestive of LPR. Treatment included the administration of omeprazole 20 mg twice daily for at least 4 weeks. Unresponsive patients were also given metoclopramide 10 mg twice daily for four additional weeks, and the dose of omeprazole was increased to 40 mg twice daily, if they did not achieve complete symptom resolution. Only patients who became completely asymptomatic after LPR treatment were included in the study. As many as 18 % of patients attending an ENT outpatient department benefited from anti-reflux treatment. A need to clear the throat represented the most common symptom, whereas interarytenoid oedema/congestion was the most common finding on flexible naso-endoscopy (62.67 and 72.7 % of patients, respectively). The vast majority of patients responded after 4 weeks of treatment with omeprazole, however, as many as 32 % of LPR patients achieved complete symptom control after the initial 4 week trial period. LPR seems to be more common than previously reported in the literature. Appropriate management of LPR can prevent the symptomatic use of various medical treatments for related manifestations, and even surgical interventions, thus decreasing the overall patient morbidity.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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Diagnosis and Management of Laryngo-Pharyngeal Reflux

Alam¹,

Vlastarakos

2012

Indian J Otolaryngol Head Neck Surg

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“…Clinical history and laryngeal examination constitutes the main diagnostic approach for LPR according to most otolaryngologists [1,2]. For this purpose, a self-administered tool, the reflux symptom index and an 8-item clinical severity scale (reflux finding score: RFS), both of which were introduced by Belafsky et al [3,4], are widely used in LPR patients [5].…”

Section: Introductionmentioning

confidence: 99%

Impact of Laryngeal Findings on Acoustic Parameters of Patients with Laryngopharyngeal Reflux

Akyıldız¹,

Öğüt²,

Varis³

et al. 2012

ORL

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Objectives: To identify the effects of laryngopharyngeal reflux (LPR)-related laryngeal findings on objective voice parameters. Methods: Two hundred and thirty patients clinically diagnosed as having LPR and 48 healthy controls were included. The reflux finding score was determined for each subject via videolaryngoscopy. The acoustic parameters evaluated were jitter, shimmer, noise-to-harmonic ratio and Voice Turbulence Index (VTI). Results: Shimmer and VTI showed statistically significant differences between the LPR and control groups among males (p < 0.05). For females, all of the 4 acoustic voice parameters were significantly different between the two groups (p < 0.05). Erythema/hyperemia was found to affect the highest number of voice parameters. VTI was found to be affected by the highest number of laryngeal findings. Conclusion: Objective voice changes were documented in LPR patients, with VTI being the most affected parameter, and therefore it should be considered in the acoustic analysis of patients with LPR in addition to the conventional parameters. With hyperemia in the first rank, ventricular obliteration, pseudosulcus and vocal fold edema are found to have an impact on voice, suggesting that these should be concentrated on in the diagnosis and follow-up of LPR patients with voice disorders.

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“…15 • Surgical management: Laproscopic or Nissen fundoplication is a well-established surgical treatment for GERD and produces reliable and reproducible results. 16 However, its role in the management of LPR is uncertain.…”

Section: Treatmentmentioning

confidence: 99%

Laryngopharyngeal Reflux: Is It the Real Culprit in Patients with Laryngeal Complaints?

Vishwakarma¹,

Shah²

2017

International Journal of Phonosurgery &Amp; Laryngology

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Aim:The aim of this study is to evaluate the role of laryngopharyngeal reflux (LPR) in patients with laryngeal complaints and study the correlation between reflux symptom index (RSI) and reflux finding score (RFS). Materials and methods:This is a study of 104 patients, who presented in the ear, nose, and throat outpatient department at the Civil Hospital, Ahmedabad, India, from April 2015 to April 2016, with complaints like change of voice, chronic cough, foreign body sensation, throat clearing, difficulty swallowing, and regurgitation.All the patients were examined with 90° endoscope by a single examiner, and an RSI ≥13 was considered as indicative of reflux. Observation and discussion:The mean age of the 104 patients was 47.2 years. The male:female ratio was 1:1.8. The RSI ranged from 5 to 44, with a mean of 22.99 and standard deviation (SD) of 7.43. The RFS ranged from 4 to 22, with a mean of 11.04 and SD of 3.07. Both the parameters showed high correlation (correlation coefficient 0.98). Conclusion:The LPR plays an important contributory role in patients with laryngeal complaints. The RFS and RSI can be used as routine parameters in establishing the diagnosis of reflux.

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Chronic rhinosinusitis and bacterial biofilms

Abstract: Progress in the treatment of nasal and paranasal sinus cancers could be achieved through better prevention and the developments of more selective treatments such as endoscopic resection, high-precision radiotherapy, and new chemotherapy drugs.

Cited by 90 publications

References 67 publications

Diagnosis and Management of Laryngo-Pharyngeal Reflux

Diagnosis and Management of Laryngo-Pharyngeal Reflux

Impact of Laryngeal Findings on Acoustic Parameters of Patients with Laryngopharyngeal Reflux

Laryngopharyngeal Reflux: Is It the Real Culprit in Patients with Laryngeal Complaints?

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