Chronic rhinosinusitis after radiotherapy in patients with head and neck cancer: a population‐based cohort study in Taiwan

Lu, Yen‐Ting; Lu, Ying‐Chou; Cheng, Hui‐Chen; Hsin, Chung‐Han; Yang, Shun‐Fa; Wang, Po‐Hui; Yeh, Huan-Jui

doi:10.1002/alr.22526

Cited by 12 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to the results of most previous studies evaluated by CT[28,32], the MRI-based L-M scores of NPC patients without sinusitis before RT was signi cantly increased after RT. These patients generally had MRI manifestations of sinusitis at 1 month after RT, and the incidence reached its highest peak at 6 months after RT, and then gradually stabilized.…”

Section: The Development Of Rissupporting

confidence: 88%

Clinical evaluation of radiation-induced sinusitis by MRI-based scoring system in nasopharyngeal carcinoma patients

Zheng

Yan

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective: To explore the application of magnetic resonance imaging (MRI) in the evaluation of radiation-induced sinusitis (RIS), MRI-based scoring system was used to evaluate the development regularity, characteristics and influencing factors of RIS in nasopharyngeal carcinoma (NPC) patients. Patients and methods:A retrospective analysis was performed by collecting the clinical and MRI data of 346 NPC patients to analyze the characteristics and prognosis of RIS. The predictive model was constructed according to the influencing factors of RIS. Results: (1) In the 2-year follow-up after radiotherapy (RT), there was significant change in L-M score in both groups of NPC patients (sinusitis before RT group: F=6.542, p=0.009 vs. non-sinusitis before RT group: F=11.702, p=0.000). After 6 months of RT, the L-M scores of the two groups tended to plateau (sinusitis before RT group: F=0.458, p=0.766 vs. non-sinusitis before RT group: F=0.500, p=0.736). (2) The prevalence of sinusitis in two groups of NPC patients (without or with sinusitis before RT) was 83% vs. 93%, 91% vs. 99%, 94% vs. 98% at 1, 6 and 24 months after RT, respectively. (3) In the patients without sinusitis before RT, the incidence of sinusitis in maxillary and anterior/posterior ethmoid, sphenoid and frontal sinuses was 87.1%, 90.0%/87.1%, 49.5%, 11.8% respectively, 1 month after RT. (4) A regression model was established according to the univariate and multivariate analysis of the factors related to RIS (smoking history: p=0.000, time after RT: p=0.008 and TNM staging: p=0.040). Conclusion: (1) RIS is a common complication in NPC patients after RT. This disorder progressed within 6 months after RT, stabilized and persisted within 6 months to 2 years. There is a high incidence of maxillary sinus and ethmoid sinus inflammation in NPC patients after RT. (2) Smoking history, time after RT and TNM staging were significant independent risk factors for RIS. (3) The intervention of the risk factors in the model may prevent or reduce the occurrence of RIS in NPC patients.

show abstract

Section: The Development Of Rissupporting

confidence: 88%

Clinical evaluation of radiation-induced sinusitis by MRI-based scoring system in nasopharyngeal carcinoma patients

Zheng

Yan

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Radiotherapy can cause damage to cilia and mucus‐secreting cell functions, which may end up in CRS. 37 , 38 , 39 However, we believe that radiotherapy induced CRS has at most a minor impact as the majority of patients stated excellent nasal breathing and those with impaired orthonasal function showed no CRS typical alterations at available paranasal sinuses CT scans. Certain limitations, however, need to be addressed based on the experimental nature of this study.…”

Section: Discussionmentioning

confidence: 89%

“…A conceivable explanation for the deteriorated orthonasal olfactory function could be secondarily developed chronic rhinosinusitis (CRS). Radiotherapy can cause damage to cilia and mucus‐secreting cell functions, which may end up in CRS 37–39 . However, we believe that radiotherapy induced CRS has at most a minor impact as the majority of patients stated excellent nasal breathing and those with impaired orthonasal function showed no CRS typical alterations at available paranasal sinuses CT scans.…”

Section: Discussionmentioning

confidence: 94%

Chemosensory Functions After Glossectomy—A Cross‐Sectional Pilot Study

et al. 2022

View full text Add to dashboard Cite

Objective To evaluate potential interactions and compensatory mechanisms of subjectively impaired taste function with ortho‐ and retronasal olfaction after glossectomy. Study Design In this cross‐sectional pilot study, chemosensory functions were assessed in 25 patients with tongue carcinomas after glossectomy. The orthonasal‐, retronasal‐, and gustatory functions were tested with a mean time of 25 months after surgery with the Sniffin’ Sticks odor identification test kit (ISST), the Candy Smell‐27 test (CST‐27) and the Taste strip test (TST). Visual analog scales (VAS) were additionally used for self‐assessment of taste, flavor perception, and odor ranging from 0 (no perception) to 10 (excellent perception) and further correlated with our psychophysical evaluated outcome measures. Results The TST, ISST, and CST‐27 tests revealed that only eight (32%) and 13 (52%) glossectomy patients had normal taste and orthonasal function, e 21 (84%) patients showed normal retronasal function. Importantly, neither extent of resection and reconstruction nor prior radiotherapy affected chemosensory functions. Contrary, 20 (80%) patients rated their taste and flavor perception as acceptable (VAS >5). Results of the TST, ISST, and CST‐27 tests did not correlate with the equivalent self‐assessments of taste (p = 0.260, r = 0.234), odor (p = 0.588, r = −0.114), and flavor (p = 0.728, r = 0.073) perception. Conclusion There was a significant discrepancy between self‐perception of taste and flavor and assessed gustatory function after glossectomy. A contribution of the intact retronasal olfactory system could be a possible explanation of our results. Level of Evidence 4 Laryngoscope, 133:375–382, 2023

show abstract

“…Our review noted that most studies were focused on the oral microbiome, whereas a single study (36) investigated the impact of RT on the sinonasal microbiome. Approximately one-sixth of patients undergoing RT for NPC will experience RT-induced rhinosinusitis (76), believed to be secondary to tissue injury, inflammation, and edema to the sinonasal cilia and mucussecreting cells (77)(78)(79). Thus, despite the frequency of tissue toxicity, the impact of RT/CRT on the sinonasal microbiome remains understudied.…”

Section: Future Directionsmentioning

confidence: 99%

The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review

et al. 2021

View full text Add to dashboard Cite

Radiation (RT) and chemoradiation therapy (CRT) play an essential role in head and neck cancer treatment. However, both cause numerous side effects in the oral cavity, paranasal sinuses, and pharynx, having deleterious consequences on patients’ quality of life. Concomitant with significant advances in radiation oncology, much attention has turned to understanding the role of the microbiome in the pathogenesis of treatment-induced tissue toxicity, to ultimately explore microbiome manipulation as a therapeutic intervention. This review sought to discuss current publications investigating the impact of RT and CRT-induced changes on the head and neck microbiome, using culture-independent molecular methods, and propose opportunities for future directions. Based on 13 studies derived from a MEDLINE, EMBASE, and Web of Science search on November 7, 2021, use of molecular methods has uncovered various phyla and genera in the head and neck microbiome, particularly the oral microbiome, not previously known using culture-based methods. However, limited research has investigated the impact of RT/CRT on subsites other than the oral cavity and none of the studies aimed to examine the relationship between the head and neck microbiome and treatment effectiveness. Findings from this review provide helpful insights on our current understanding of treatment-induced oral mucositis, dental plaque, and caries formation and highlight the need for future research to examine the effect of RT/CRT on the sinonasal and oropharyngeal microbiome. In addition, future research should use larger cohorts, examine the impact of the microbiome on treatment response, and study the effect of manipulating the microbiome to overcome therapy resistance.

show abstract

Chronic rhinosinusitis after radiotherapy in patients with head and neck cancer: a population‐based cohort study in Taiwan

Cited by 12 publications

References 16 publications

Clinical evaluation of radiation-induced sinusitis by MRI-based scoring system in nasopharyngeal carcinoma patients

Clinical evaluation of radiation-induced sinusitis by MRI-based scoring system in nasopharyngeal carcinoma patients

Chemosensory Functions After Glossectomy—A Cross‐Sectional Pilot Study

The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review

Contact Info

Product

Resources

About