Chronic Repetitive Suppurations of Skin Associated with a Serum Factor Affecting Bactericidal Capacity of Polymorphonuclear Leukocytes

Hodgson, G.A.; Thompson, E. N.

doi:10.1177/003591577206500813

Cited by 4 publications

(5 citation statements)

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“…Of the remaining children, two were HIV positive (19), one had IgA deficiency (20), and one had a neutrophil and T cell deficiency (21). Twelve (26.6%) had no underlying disorder (22)(23)(24)(25)(26)(27)(28)(29)(30)(31), which is comparable to the 20% to 30% figure reported for adults (33).…”

Section: Associated Disordersmentioning

confidence: 62%

Pyoderma Gangrenosum in Infants and Children

Graham¹,

Hansen²,

Rabinowitz

et al. 1994

Pediatric Dermatology

127

108

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Pyoderma gangrenosum is an uncommon ulcerative skin disorder that occurs in all age groups. Approximately 4% of patients are infants and children. There are several notable differences between the childhood and adult manifestations of the disease, including the distribution of lesions and associated disorders. We reviewed the childhood cases (< or = 18 yrs of age) of unequivocal pyoderma gangrenosum in the English literature and tabulated the trends in clinical features, associated disorders, and therapy. We report our 3-week-old patient, the youngest documented case. Of the 46 patients, only 4 were less than 1 year of age. A systemic illness was present in 74% of the older children, most commonly, ulcerative colitis. Only one infant had an associated problem (HIV+) at the time of onset. Infants appear to have an unusual distribution of perianal and genital lesions not often described in other age groups. Our review suggests that pyoderma gangrenosum in children has a similar clinical appearance to that in adults. It is associated with some of the same underlying disorders, but with different frequencies. The distribution of lesions in children is similar, often involving the lower extremities, but pyoderma gangrenosum of the head and face appears to be more common in children. Infants may have ulcers in genital and perianal areas. The most frequently prescribed treatment for children is systemic corticosteroids, which generally are very effective.

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Section: Associated Disordersmentioning

confidence: 62%

Pyoderma Gangrenosum in Infants and Children

Graham¹,

Hansen²,

Rabinowitz

et al. 1994

Pediatric Dermatology

127

108

View full text Add to dashboard Cite

show abstract

“…Management of the periodontal disease in this patient was made more difficult by the history of severe infection following even minor surgical intervention (Hodgson & Thompson 1972). In addition, the parents were concerned that numerous hospital appointments would interfere with her scholastic progress.…”

Section: Discussionmentioning

confidence: 96%

“…Intracellular killing of the organism was impaired, however, in the presence of the patient's (autologous) serum. This was a selective effect of the patient's serum on her own polymorphs, since it did not affect intracellular digestion in polymorphs from healthy persons (Hodgson & Thompson 1972).…”

Section: Case Reportmentioning

confidence: 92%

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The periodontal management of a patient with a profound immunodeficiency disorder

Roberts

Walker

1976

J Clinic Periodontology

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A case of severe, uncontrolled periodontal disease in a patient with a profound immunodeficiency disorder is reported. The periodontal disease was noted before the age of 10 years and is generalized, with marked associated alveolar bone loss, even threatening a mandibular fracture. Severely involved teeth were allowed to exfoliate, and extractions were avoided. At the age of 17 years, the patient now has only nine remaining teeth. The management adopted and alternative approaches are critically reviewed. The implications of the dental findings for current concepts of the pathogenesis of periodontal disease and dental caries are discussed.

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“…Comment. The case has been shown at the Royal Society of Medicine (Hodgson & Thompson, 1972) and considered to be due to an unknown serum factor( ?) circulating inhibitor or lack of substance required for normal leukocyte function.…”

mentioning

confidence: 99%